Search: id:"swepub:oai:DiVA.org:uu-320667" >
Unfractionated hepa...
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Grimfjärd, PerUppsala University,Uppsala universitet,Kardiologi,Västerås Univ, Dept Cardiol, Västerås, Sweden.,Västmanland Hospital
(author)
Unfractionated heparin versus bivalirudin in patients undergoing primary percutaneous coronary intervention : a SWEDEHEART study
- Article/chapterEnglish2017
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Numbers
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LIBRIS-ID:oai:DiVA.org:uu-320667
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-320667URI
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https://lup.lub.lu.se/record/560a83ea-2b2f-40f5-af26-76a01944481dURI
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https://doi.org/10.4244/EIJ-D-16-00884DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Aims: The aim of the stud was to compare outcomes in unfractionated heparin (UM) and bivalirudintreated patients undergoing primary percutaneous coronary intervention (PPCI). Methods and results: This observational study contained 20,612 PPCT patients treated with either GM monotherapv or bivalirudin with or without concomitant UFE. Patients with oral anticoagulant or glycoprotein IIb/IIIa inhibitor (GPI) treatment were excluded. The primary outcome measure was definite early stent thrombosis (Si) that occurred at low and similar rates in UNA only and bivalirudin-treated patients: 0.9% vs. 0.8% (adjusted hazard ratio [HR] 1.08, 95% confidence interval [CI]: 0.7-1.65). All-cause death at 30 days occurred in 6.9% vs. 5.4% of patients (adjusted HR 1.23, 95% Cl: 1.05-1.44) and within 365 days in 12.1% vs. 8.9% (adjusted HR 1.34, 95% CI: 1.19-1.52) in the two groups, respectively. The incidence of major bleeding within 30 days was 0.8% vs. 0.6% (adjusted HR 1.54, 95% CI: 0.97-2.45). The incidence of reinfarction within 365 days and stroke within 30 days was similar between groups. Conclusions: In this large, nationwide observational study we found low and similar rates of early ST in UFH only and bivalirudin-treated patients undergoing primary PCI. Mortality was higher in IJFH compared with bivalirudin-treated patients.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Erlinge, DavidLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)kard-der
(author)
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Koul, SashaLund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)med-sku
(author)
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Lagerqvist, Bo,1952-Uppsala University,Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala University Hospital(Swepub:uu)bolager
(author)
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Svennblad, BodilUppsala universitet,Uppsala kliniska forskningscentrum (UCR),Ortopedi,Uppsala University Hospital(Swepub:uu)bosve677
(author)
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Varenhorst, Christoph,1977-Uppsala University,Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala University Hospital(Swepub:uu)chrva923
(author)
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James, Stefan K.,1964-Uppsala University,Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala University Hospital(Swepub:uu)stjam367
(author)
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Uppsala universitetKardiologi
(creator_code:org_t)
Related titles
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In:EuroIntervention12:16, s. 2009-20171774-024X1969-6213
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