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Doxorubicin enhance...
Doxorubicin enhances the capacity of B cells to activate T cells in urothelial urinary bladder cancer
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- Zirakzadeh, A. Ali (author)
- Karolinska Institutet
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- Kinn, Johan (author)
- Karolinska Inst, Unit Immunol & Allergy, Dept Med, Stockholm, Sweden
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- Krantz, David (author)
- Karolinska Institutet
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- Rosenblatt, Robert (author)
- Umeå universitet,Urologi och andrologi,Department of Urology, Stockholm South General Hospital, Karolinska Institutet, Stockholm, Sweden,Umeå Univ Hosp, Dept Surg & Perioperat Sci Urol & Androl, Umeå, Sweden; Karolinska Inst, Stockholm South Gen Hosp, Dept Urol, Stockholm, Sweden
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- Winerdal, Malin E. (author)
- Karolinska Institutet
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- Hu, Jin (author)
- Karolinska Inst, Unit Immunol & Allergy, Dept Med, Stockholm, Sweden
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- Hartana, Ciputra Adijaya (author)
- Karolinska Inst, Unit Immunol & Allergy, Dept Med, Stockholm, Sweden
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- Lundgren, Christian (author)
- Karolinska Inst, Unit Immunol & Allergy, Dept Med, Stockholm, Sweden
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- Bergman, Emma Ahlén (author)
- Karolinska Institutet
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- Johansson, Markus (author)
- Sundsvall Hosp, Dept Urol, Sundsvall, Sweden
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- Holmström, Benny (author)
- Uppsala universitet,Urologkirurgi
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- Hansson, Johan, 1964- (author)
- Uppsala universitet,Centrum för klinisk forskning, Gävleborg
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- Sidikii, Alexander (author)
- Länssjukhuset Ryhov, Dept Urol, Region Jonköping, Sweden
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- Vasko, Janos (author)
- Umeå universitet,Patologi,Umeå Univ, Dept Med Biosci, Pathol, Umeå, Sweden
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- Marits, Per (author)
- Karolinska Institutet
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- Sherif, Amir (author)
- Umeå universitet,Urologi och andrologi,Umeå Univ Hosp, Dept Surg & Perioperat Sci Urol & Androl, Umeå, Sweden
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- Winqvist, Ola (author)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
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In: Clinical Immunology. - : Elsevier BV. - 1521-6616 .- 1521-7035. ; 176, s. 63-70
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- Cancer is currently treated by a combination of therapies, including chemotherapy which is believed to suppress the immune system. Combination of immunotherapy and chemotherapy correlates with improved survival but needs careful planning in order to achieve a synergistic effect. In this study, we have demonstrated that doxorubicin treatment of B cells resulted in increased expression of CD86 and concordantly increased CD4(+) T cell activation in the presence of superantigen, an effect that was inhibited by the addition of a CD86 blocking antibody. Furthermore, doxorubicin resulted in decreased expression of the anti-inflammatory cytokines IL-10 and TNF-alpha. Finally, B cells from urinary bladder cancer patients, treated with a neoadjuvant regiment containing doxorubicin, displayed increased CD86-expression. We conclude that doxorubicin induces CD86 expression on B cells and hence enhances their antigen-presenting ability in vitro, a finding verified in patients. Development of tailored time and dose schedules may increase the effectiveness of combining chemotherapy and immunotherapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- Doxorubicin
- B cells
- Immunology
- Urinary bladder cancer
- Neoadjuvant chemotherapy
- CD86
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Zirakzadeh, A. A ...
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Kinn, Johan
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Krantz, David
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Rosenblatt, Robe ...
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Winerdal, Malin ...
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Hu, Jin
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show more...
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Hartana, Ciputra ...
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Lundgren, Christ ...
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Bergman, Emma Ah ...
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Johansson, Marku ...
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Holmström, Benny
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Hansson, Johan, ...
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Sidikii, Alexand ...
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Vasko, Janos
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Marits, Per
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Sherif, Amir
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Winqvist, Ola
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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Clinical Immunol ...
- By the university
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Uppsala University
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Umeå University
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Karolinska Institutet