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  • Zirakzadeh, A. AliKarolinska Institutet (author)

Doxorubicin enhances the capacity of B cells to activate T cells in urothelial urinary bladder cancer

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • Elsevier BV,2017
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-320835
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-320835URI
  • https://doi.org/10.1016/j.clim.2016.12.003DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-131335URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:135398467URI

Supplementary language notes

  • Language:English
  • Summary in:English

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Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Cancer is currently treated by a combination of therapies, including chemotherapy which is believed to suppress the immune system. Combination of immunotherapy and chemotherapy correlates with improved survival but needs careful planning in order to achieve a synergistic effect. In this study, we have demonstrated that doxorubicin treatment of B cells resulted in increased expression of CD86 and concordantly increased CD4(+) T cell activation in the presence of superantigen, an effect that was inhibited by the addition of a CD86 blocking antibody. Furthermore, doxorubicin resulted in decreased expression of the anti-inflammatory cytokines IL-10 and TNF-alpha. Finally, B cells from urinary bladder cancer patients, treated with a neoadjuvant regiment containing doxorubicin, displayed increased CD86-expression. We conclude that doxorubicin induces CD86 expression on B cells and hence enhances their antigen-presenting ability in vitro, a finding verified in patients. Development of tailored time and dose schedules may increase the effectiveness of combining chemotherapy and immunotherapy.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Kinn, JohanKarolinska Inst, Unit Immunol & Allergy, Dept Med, Stockholm, Sweden (author)
  • Krantz, DavidKarolinska Institutet (author)
  • Rosenblatt, RobertUmeå universitet,Urologi och andrologi,Department of Urology, Stockholm South General Hospital, Karolinska Institutet, Stockholm, Sweden,Umeå Univ Hosp, Dept Surg & Perioperat Sci Urol & Androl, Umeå, Sweden; Karolinska Inst, Stockholm South Gen Hosp, Dept Urol, Stockholm, Sweden(Swepub:umu)roro0025 (author)
  • Winerdal, Malin E.Karolinska Institutet (author)
  • Hu, JinKarolinska Inst, Unit Immunol & Allergy, Dept Med, Stockholm, Sweden (author)
  • Hartana, Ciputra AdijayaKarolinska Inst, Unit Immunol & Allergy, Dept Med, Stockholm, Sweden (author)
  • Lundgren, ChristianKarolinska Inst, Unit Immunol & Allergy, Dept Med, Stockholm, Sweden (author)
  • Bergman, Emma AhlénKarolinska Institutet (author)
  • Johansson, MarkusSundsvall Hosp, Dept Urol, Sundsvall, Sweden (author)
  • Holmström, BennyUppsala universitet,Urologkirurgi (author)
  • Hansson, Johan,1964-Uppsala universitet,Centrum för klinisk forskning, Gävleborg(Swepub:uu)johan031 (author)
  • Sidikii, AlexanderLänssjukhuset Ryhov, Dept Urol, Region Jonköping, Sweden (author)
  • Vasko, JanosUmeå universitet,Patologi,Umeå Univ, Dept Med Biosci, Pathol, Umeå, Sweden(Swepub:umu)jasvao04 (author)
  • Marits, PerKarolinska Institutet (author)
  • Sherif, AmirUmeå universitet,Urologi och andrologi,Umeå Univ Hosp, Dept Surg & Perioperat Sci Urol & Androl, Umeå, Sweden(Swepub:umu)amsh0008 (author)
  • Winqvist, OlaKarolinska Institutet (author)
  • Karolinska InstitutetKarolinska Inst, Unit Immunol & Allergy, Dept Med, Stockholm, Sweden (creator_code:org_t)

Related titles

  • In:Clinical Immunology: Elsevier BV176, s. 63-701521-66161521-7035

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