Search: ((WFRF:(Li Man)) pers:(Franco Oscar H.) pers:(Harris Tamara B.)) >
1000 Genomes-based ...
1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function.
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Gorski, Mathias (author)
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van der Most, Peter J (author)
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Teumer, Alexander (author)
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show more...
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Chu, Audrey Y (author)
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Li, Man (author)
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Mijatovic, Vladan (author)
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Nolte, Ilja M (author)
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Cocca, Massimiliano (author)
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Taliun, Daniel (author)
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Gomez, Felicia (author)
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Li, Yong (author)
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Tayo, Bamidele (author)
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Tin, Adrienne (author)
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Feitosa, Mary F (author)
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Aspelund, Thor (author)
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Attia, John (author)
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Biffar, Reiner (author)
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Bochud, Murielle (author)
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Boerwinkle, Eric (author)
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Borecki, Ingrid (author)
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Bottinger, Erwin P (author)
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Chen, Ming-Huei (author)
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Chouraki, Vincent (author)
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Ciullo, Marina (author)
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Coresh, Josef (author)
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Cornelis, Marilyn C (author)
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Curhan, Gary C (author)
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d'Adamo, Adamo Pio (author)
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Dehghan, Abbas (author)
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Dengler, Laura (author)
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Ding, Jingzhong (author)
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Eiriksdottir, Gudny (author)
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Endlich, Karlhans (author)
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- Enroth, Stefan, 1976- (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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Esko, Tõnu (author)
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Franco, Oscar H (author)
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Gasparini, Paolo (author)
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Gieger, Christian (author)
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Girotto, Giorgia (author)
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Gottesman, Omri (author)
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Gudnason, Vilmundur (author)
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Gyllensten, Ulf (author)
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Hancock, Stephen J (author)
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Harris, Tamara B (author)
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Helmer, Catherine (author)
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Höllerer, Simon (author)
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Hofer, Edith (author)
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Hofman, Albert (author)
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Holliday, Elizabeth G (author)
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Homuth, Georg (author)
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Hu, Frank B (author)
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Huth, Cornelia (author)
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Hutri-Kähönen, Nina (author)
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Hwang, Shih-Jen (author)
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Imboden, Medea (author)
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- Johansson, Åsa (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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Kähönen, Mika (author)
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König, Wolfgang (author)
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Kramer, Holly (author)
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Krämer, Bernhard K (author)
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Kumar, Ashish (author)
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Kutalik, Zoltan (author)
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Lambert, Jean-Charles (author)
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Launer, Lenore J (author)
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Lehtimäki, Terho (author)
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de Borst, Martin (author)
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Navis, Gerjan (author)
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Swertz, Morris (author)
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Liu, Yongmei (author)
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Lohman, Kurt (author)
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Loos, Ruth J F (author)
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Lu, Yingchang (author)
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Lyytikäinen, Leo-Pekka (author)
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McEvoy, Mark A (author)
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Meisinger, Christa (author)
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Meitinger, Thomas (author)
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Metspalu, Andres (author)
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Metzger, Marie (author)
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Mihailov, Evelin (author)
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Mitchell, Paul (author)
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Nauck, Matthias (author)
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Oldehinkel, Albertine J (author)
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Olden, Matthias (author)
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Wjh Penninx, Brenda (author)
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Pistis, Giorgio (author)
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Pramstaller, Peter P (author)
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Probst-Hensch, Nicole (author)
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Raitakari, Olli T (author)
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Rettig, Rainer (author)
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Ridker, Paul M (author)
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Rivadeneira, Fernando (author)
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Robino, Antonietta (author)
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Rosas, Sylvia E (author)
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Ruderfer, Douglas (author)
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Ruggiero, Daniela (author)
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Saba, Yasaman (author)
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Sala, Cinzia (author)
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Schmidt, Helena (author)
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Schmidt, Reinhold (author)
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Scott, Rodney J (author)
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Sedaghat, Sanaz (author)
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Smith, Albert V (author)
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Sorice, Rossella (author)
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Stengel, Benedicte (author)
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Stracke, Sylvia (author)
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Strauch, Konstantin (author)
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Toniolo, Daniela (author)
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Uitterlinden, Andre G (author)
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Ulivi, Sheila (author)
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Viikari, Jorma S (author)
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Völker, Uwe (author)
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Vollenweider, Peter (author)
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Völzke, Henry (author)
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Vuckovic, Dragana (author)
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Waldenberger, Melanie (author)
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Jin Wang, Jie (author)
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Yang, Qiong (author)
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Chasman, Daniel I (author)
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Tromp, Gerard (author)
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Snieder, Harold (author)
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Heid, Iris M (author)
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Fox, Caroline S (author)
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Köttgen, Anna (author)
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Pattaro, Cristian (author)
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Böger, Carsten A (author)
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Fuchsberger, Christian (author)
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(creator_code:org_t)
- 2017-04-28
- 2017
- English.
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7
- Related links:
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https://uu.diva-port... (primary) (Raw object)
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- HapMap imputed genome-wide association studies (GWAS) have revealed >50 loci at which common variants with minor allele frequency >5% are associated with kidney function. GWAS using more complete reference sets for imputation, such as those from The 1000 Genomes project, promise to identify novel loci that have been missed by previous efforts. To investigate the value of such a more complete variant catalog, we conducted a GWAS meta-analysis of kidney function based on the estimated glomerular filtration rate (eGFR) in 110,517 European ancestry participants using 1000 Genomes imputed data. We identified 10 novel loci with p-value < 5 × 10(-8) previously missed by HapMap-based GWAS. Six of these loci (HOXD8, ARL15, PIK3R1, EYA4, ASTN2, and EPB41L3) are tagged by common SNPs unique to the 1000 Genomes reference panel. Using pathway analysis, we identified 39 significant (FDR < 0.05) genes and 127 significantly (FDR < 0.05) enriched gene sets, which were missed by our previous analyses. Among those, the 10 identified novel genes are part of pathways of kidney development, carbohydrate metabolism, cardiac septum development and glucose metabolism. These results highlight the utility of re-imputing from denser reference panels, until whole-genome sequencing becomes feasible in large samples.
Publication and Content Type
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- art (subject category)
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To the university's database
- By the author/editor
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Gorski, Mathias
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van der Most, Pe ...
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Teumer, Alexande ...
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Chu, Audrey Y
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Li, Man
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Mijatovic, Vlada ...
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show more...
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Nolte, Ilja M
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Cocca, Massimili ...
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Taliun, Daniel
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Gomez, Felicia
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Li, Yong
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Tayo, Bamidele
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Tin, Adrienne
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Feitosa, Mary F
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Aspelund, Thor
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Attia, John
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Biffar, Reiner
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Bochud, Murielle
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Boerwinkle, Eric
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Borecki, Ingrid
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Bottinger, Erwin ...
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Chen, Ming-Huei
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Chouraki, Vincen ...
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Ciullo, Marina
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Coresh, Josef
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Cornelis, Marily ...
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Curhan, Gary C
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d'Adamo, Adamo P ...
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Dehghan, Abbas
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Dengler, Laura
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Ding, Jingzhong
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Eiriksdottir, Gu ...
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Endlich, Karlhan ...
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Enroth, Stefan, ...
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Esko, Tõnu
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Franco, Oscar H
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Gasparini, Paolo
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Gieger, Christia ...
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Girotto, Giorgia
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Gottesman, Omri
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Gudnason, Vilmun ...
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Gyllensten, Ulf
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Hancock, Stephen ...
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Harris, Tamara B
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Helmer, Catherin ...
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Höllerer, Simon
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Hofer, Edith
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Hofman, Albert
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Holliday, Elizab ...
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Homuth, Georg
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Hu, Frank B
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Huth, Cornelia
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Hutri-Kähönen, N ...
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Hwang, Shih-Jen
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Imboden, Medea
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Johansson, Åsa
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Kähönen, Mika
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König, Wolfgang
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Kramer, Holly
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Krämer, Bernhard ...
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Kumar, Ashish
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Kutalik, Zoltan
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Lambert, Jean-Ch ...
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Launer, Lenore J
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Lehtimäki, Terho
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de Borst, Martin
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Navis, Gerjan
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Swertz, Morris
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Liu, Yongmei
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Lohman, Kurt
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Loos, Ruth J F
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Lu, Yingchang
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Lyytikäinen, Leo ...
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McEvoy, Mark A
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Meisinger, Chris ...
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Meitinger, Thoma ...
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Metspalu, Andres
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Metzger, Marie
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Mihailov, Evelin
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Mitchell, Paul
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Nauck, Matthias
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Oldehinkel, Albe ...
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Olden, Matthias
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Wjh Penninx, Bre ...
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Pistis, Giorgio
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Pramstaller, Pet ...
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Probst-Hensch, N ...
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Raitakari, Olli ...
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Rettig, Rainer
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Ridker, Paul M
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Rivadeneira, Fer ...
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Robino, Antoniet ...
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Rosas, Sylvia E
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Ruderfer, Dougla ...
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Ruggiero, Daniel ...
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Saba, Yasaman
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Sala, Cinzia
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Schmidt, Helena
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Schmidt, Reinhol ...
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Scott, Rodney J
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Sedaghat, Sanaz
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Smith, Albert V
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Sorice, Rossella
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Stengel, Benedic ...
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Stracke, Sylvia
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Strauch, Konstan ...
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Toniolo, Daniela
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Uitterlinden, An ...
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Ulivi, Sheila
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Viikari, Jorma S
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Völker, Uwe
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Vollenweider, Pe ...
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Völzke, Henry
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Vuckovic, Dragan ...
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Waldenberger, Me ...
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Jin Wang, Jie
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Yang, Qiong
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Chasman, Daniel ...
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Tromp, Gerard
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Snieder, Harold
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Heid, Iris M
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Fox, Caroline S
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Köttgen, Anna
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Pattaro, Cristia ...
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Böger, Carsten A
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Fuchsberger, Chr ...
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- Articles in the publication
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Scientific Repor ...
- By the university
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Uppsala University
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Karolinska Institutet