Multiple breath-hold proton spectroscopy of human liver at 3T: Relaxation times and concentrations of glycogen, choline, and lipids

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Weis, Jan,1956-Uppsala universitet,Radiologi (författare)

Multiple breath-hold proton spectroscopy of human liver at 3T : Relaxation times and concentrations of glycogen, choline, and lipids

Artikel/kapitelEngelska2018

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2017-04-17
Wiley,2018
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-322145
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-322145URI
https://doi.org/10.1002/jmri.25734DOI

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Språk:engelska
Sammanfattning på:engelska

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Purpose:To evaluate the feasibility of an expiration multiple breath-hold H-1-MRS technique to measure glycogen (Glycg), choline-containing compounds (CCC), and lipid relaxation times T-1, T-2, and their concentrations in normal human liver.Materials and Methods:Thirty healthy volunteers were recruited. Experiments were performed at 3T. Multiple expiration breath-hold single-voxel point-resolved spectroscopy (PRESS) technique was used for localization. Water-suppressed spectra were used for the estimation of Glycg, CCC, lipid methylene (CH2)(n) relaxation times and concentrations. Residual water lines were removed by the Hankel Lanczos singular value decomposition filter. After phase correction and frequency alignment, spectra were averaged and processed by LCModel. Summed signals of Glycg resonances H2H4', H3, and H5 between 3.6 and 4ppm were used to estimate their apparent relaxation times and concentration. Glycg, CCC, and lipid content were estimated from relaxation corrected spectral intensity ratios to unsuppressed water line.Results:Relaxation times were measured for liver Glycg (T-1, 892 +/- 126 msec; T-2, 134 msec), CCC (T-1, 842 +/- 75 msec; T-2, 505 msec), lipid (CH2)(n) (T-1, 402 +/- 19 msec; T-2, 52 +/- 3 msec), and water (T-1, 990 +/- 89 msec; T-2, 30 +/- 2 msec). Mean CCC and lipid concentrations of healthy liver were 7.8 +/- 1.3 mM and 15.8 +/- 23.6 mM, respectively. Glycg content was found lower in the morning (48 +/- 21 mM) compared to the afternoon (145 +/- 50 mM).Conclusion:Multiple breath-hold H-1-MRS together with dedicated postprocessing is a feasible technique for the quantification of liver Glycg, CCC, and lipid relaxation times and concentrations.

Ämnesord och genrebeteckningar

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Radiologi och bildbehandling hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Radiology, Nuclear Medicine and Medical Imaging hsv//eng
choline
glycogen
liver
magnetic resonance spectroscopy
quantification
relaxation times

Biuppslag (personer, institutioner, konferenser, titlar ...)

Kullberg, Joel,1979-Uppsala universitet,Radiologi(Swepub:uu)jokul377 (författare)
Ahlström, Håkan,1953-Uppsala universitet,Radiologi(Swepub:uu)hakanahl (författare)
Uppsala universitetRadiologi (creator_code:org_t)

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Ingår i:Journal of Magnetic Resonance Imaging: Wiley47, s. 410-4171053-18071522-2586

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Av författaren/redakt...: Weis, Jan, 1956-; Kullberg, Joel, ...; Ahlström, Håkan, ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Radiologi och bi ...

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Av lärosätet: Uppsala universitet

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