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Ranolazine After In...
Ranolazine After Incomplete Percutaneous Coronary Revascularization in Patients With Versus Without Diabetes Mellitus : RIVER-PCI Trial
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- Fanaroff, Alexander C. (author)
- Duke Univ, Med Ctr, Div Cardiol, Dept Med, Durham, NC 27710 USA.;Duke Univ, Med Ctr, Duke Clin Res Inst, 2400 Pratt St, Durham, NC 27705 USA.
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- James, Stefan K., 1964- (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- Weisz, Giora (author)
- Columbia Univ, Div Cardiol, New York, NY USA.;Cardiovasc Res Fdn, New York, NY USA.;Shaare Zedek Med Ctr, Dept Cardiol, Jerusalem, Israel.
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- Prather, Kristi (author)
- Duke Univ, Med Ctr, Duke Clin Res Inst, 2400 Pratt St, Durham, NC 27705 USA.
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- Anstrom, Kevin J. (author)
- Duke Univ, Med Ctr, Duke Clin Res Inst, 2400 Pratt St, Durham, NC 27705 USA.
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- Mark, Daniel B. (author)
- Duke Univ, Med Ctr, Div Cardiol, Dept Med, Durham, NC 27710 USA.;Duke Univ, Med Ctr, Duke Clin Res Inst, 2400 Pratt St, Durham, NC 27705 USA.
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- Ben-Yehuda, Ori (author)
- Cardiovasc Res Fdn, New York, NY USA.
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- Alexander, Karen P. (author)
- Duke Univ, Med Ctr, Div Cardiol, Dept Med, Durham, NC 27710 USA.;Duke Univ, Med Ctr, Duke Clin Res Inst, 2400 Pratt St, Durham, NC 27705 USA.
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- Stone, Gregg W. (author)
- Columbia Univ, Div Cardiol, New York, NY USA.;Cardiovasc Res Fdn, New York, NY USA.
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- Ohman, E. Magnus (author)
- Duke Univ, Med Ctr, Div Cardiol, Dept Med, Durham, NC 27710 USA.;Duke Univ, Med Ctr, Duke Clin Res Inst, 2400 Pratt St, Durham, NC 27705 USA.
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Duke Univ, Med Ctr, Div Cardiol, Dept Med, Durham, NC 27710 USA;Duke Univ, Med Ctr, Duke Clin Res Inst, 2400 Pratt St, Durham, NC 27705 USA. Uppsala kliniska forskningscentrum (UCR) (creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
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In: Journal of the American College of Cardiology. - : Elsevier BV. - 0735-1097 .- 1558-3597. ; 69:18, s. 2304-2313
- Related links:
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https://doi.org/10.1...
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Abstract
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- BACKGROUND Chronic angina is more common in patients with diabetes mellitus (DM) with poor glucose control. Ranolazine both treats chronic angina and improves glucose control.OBJECTIVES This study sought to examine ranolazine's antianginal effect in relation to glucose control.METHODS The authors performed a secondary analysis of the RIVER-PCI (Ranolazine in Patients with Incomplete Revascularization after Percutaneous Coronary Intervention) trial, a clinical trial in which 2,604 patients with chronic angina and incomplete revascularization following percutaneous coronary intervention were randomized to ranolazine versus placebo. Mixed-effects models were used to compare the effects of ranolazine versus placebo on glycosylated hemoglobin (HbA(1c)) at 6- and 12-month follow-up. Interaction between baseline HbA(1c) and ranolazine's effect on Seattle Angina Questionnaire angina frequency at 6 and 12 months was tested.RESULTS Overall, 961 patients (36.9%) had DM at baseline. Compared with placebo, ranolazine significantly decreased HbA(1c) by 0.42 +/- 0.08% (adjusted mean difference +/- SE) and 0.44 +/- 0.08% from baseline to 6 and 12 months, respectively, in DM patients, and by 0.19 +/- 0.02% and 0.20 +/- 0.02% at 6 and 12 months, respectively, in non-DM patients. Compared with placebo, ranolazine significantly reduced Seattle Angina Questionnaire angina frequency at 6 months among DM patients but not at 12 months. The reductions in angina frequency were numerically greater among patients with baseline HbA(1c) >= 7.5% than those with HbA(1c) <7.5% (interaction p = 0.07).CONCLUSIONS In patients with DM and chronic angina with incomplete revascularization after percutaneous coronary intervention, ranolazine's effect on glucose control and angina at 6 months was proportionate to baseline HbA(1c), but the effect on angina dissipated by 12 months.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- chronic angina
- coronary artery disease
- glucose control
- hemoglobin A(1c)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Fanaroff, Alexan ...
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James, Stefan K. ...
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Weisz, Giora
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Prather, Kristi
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Anstrom, Kevin J ...
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Mark, Daniel B.
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Ben-Yehuda, Ori
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Alexander, Karen ...
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Stone, Gregg W.
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Ohman, E. Magnus
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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Uppsala University