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Allogeneic Hematopo...
Allogeneic Hematopoietic Cell Transplantation for Adult Chronic Myelomonocytic Leukemia
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Liu, Hien Duong (author)
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- Ahn, Kwang Woo (author)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA.
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- Hu, Zhen-Huan (author)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
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- Hamadani, Mehdi (author)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
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- Nishihori, Taiga (author)
- H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL USA.
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- Wirk, Baldeep (author)
- Seattle Canc Care Alliance, Div Bone Marrow Transplant, Seattle, WA USA.
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- Beitinjaneh, Amer (author)
- Univ Miami, Sylvester Canc Ctr, Dept Hematol & Oncol, Miami, FL USA.
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- Rizzieri, David (author)
- Duke Univ, Div Hematol Malignancies & Cellular Therapy, Durham, NC USA.
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- Grunwald, Michael R. (author)
- Carolinas HealthCare Syst, Levine Canc Inst, Dept Hematol Oncol & Blood Disorders, Charlotte, NC USA.
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- Sabloff, Mitchell (author)
- Univ Ottawa, Dept Med, Div Hematol, Ottawa, ON, Canada.;Ottawa Hosp Res Inst, Ottawa, ON, Canada.
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- Olsson, Richard F. (author)
- Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Div Therapeut Immunol, Stockholm, Sweden.
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- Bajel, Ashish (author)
- Royal Melbourne Hosp, Dept Haematol & Bone Marrow Transplant, Parkville, Vic, Australia.
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- Bredeson, Christopher (author)
- Ottawa Hosp Res Inst, Ottawa, ON, Canada.;Ottawa Hosp, Blood & Marrow Transplant Program, Ottawa, ON, Canada.
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- Daly, Andrew (author)
- Tom Baker Canc Clin, Dept Med, Calgary, AB, Canada.;Tom Baker Canc Clin, Dept Oncol, Calgary, AB, Canada.
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- Inamoto, Yoshihiro (author)
- Natl Canc Ctr, Div Hematopoiet Stem Cell Transplantat, Tokyo, Japan.
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- Majhail, Navneet (author)
- Cleveland Clin, Taussig Canc Inst, Blood & Marrow Transplant Program, Cleveland, OH 44106 USA.
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- Saad, Ayman (author)
- Univ Alabama Birmingham, Dept Med, Div Hematol Oncol, Birmingham, AL USA.
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- Gupta, Vikas (author)
- Univ Hlth Network, Princess Margaret Canc Ctr, Blood & Marrow Transplant Program, Toronto, ON, Canada.
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- Gerds, Aaron (author)
- Cleveland Clin, Taussig Canc Inst, Hematol Oncol & Blood Disorders, Cleveland, OH 44106 USA.
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- Malone, Adriana (author)
- Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA.
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- Tallman, Martin (author)
- Mem Sloan, Dept Med, Leukemia Serv, New York, NY USA.
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- Reshef, Ran (author)
- Columbia Univ, Med Ctr, Blood & Marrow Transplantat Program, New York, NY USA.;Columbia Univ, Med Ctr, Columbia Ctr Translat Immunol, New York, NY USA.
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- Marks, David I. (author)
- Univ Hosp Bristol NHS Trust, Pediat Bone Marrow Transplant, Bristol, Avon, England.
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- Copelan, Edward (author)
- Carolinas HealthCare Syst, Levine Canc Inst, Dept Hematol Oncol & Blood Disorders, Charlotte, NC USA.
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- Gergis, Usama (author)
- New York Presbyterian Hosp, Weill Cornell Med Ctr, Dept Med Oncol, Hematol Malignancies & Bone Marrow Transplant, New York, NY USA.
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- Savoie, Mary Lynn (author)
- Tom Baker Canc Clin, Div Hematol & Hematol Malignancies, Calgary, AB, Canada.
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- Ustun, Celalettin (author)
- Univ Minnesota, Med Ctr, Dept Med, Div Hematol Oncol & Transplantat, Minneapolis, MN 55455 USA.
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- Litzow, Mark R. (author)
- Mayo Clin Rochester, Div Hematol, Rochester, MN USA.;Mayo Clin Rochester, Transplant Ctr, Rochester, MN USA.
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- Cahn, Jean-Yves (author)
- Univ Hosp, Dept Hematol, Grenoble, France.
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- Kindwall-Keller, Tamila (author)
- Univ Virginia Hlth Syst, Div Hematol Oncol, Charlottesville, VA USA.
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- Akpek, Gorgun (author)
- Banner MD Anderson Canc Ctr, Stem Cell Transplantat & Cellular Therapy Program, Gilbert, AZ USA.
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- Savani, Bipin N. (author)
- Vanderbilt Univ, Med Ctr, Dept Med, Div Hematol Oncol, Nashville, TN USA.
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- Aljurf, Mahmoud (author)
- King Faisal Specialist Hosp Ctr & Res, Dept Oncol, Riyadh, Saudi Arabia.
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- Rowe, Jacob M. (author)
- Shaare Zedek Med Ctr, Dept Hematol, Jerusalem, Israel.
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- Wiernik, Peter H. (author)
- Our Lady Mercy Med Ctr, Bronx, NY USA.
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- Hsu, Jack W. (author)
- Shands HealthCare, Dept Med, Div Hematol & Oncol, Gainesville, FL USA.;Univ Florida, Gainesville, FL USA.
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- Cortes, Jorge (author)
- Univ Texas MD Anderson Canc Ctr, Div Canc Med, Dept Leukemia, Houston, TX 77030 USA.
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- Kalaycio, Matt (author)
- Cleveland Clin Fdn, Dept Hematol & Med Oncol, 9500 Euclid Ave, Cleveland, OH 44195 USA.
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- Maziarz, Richard (author)
- Oregon Hlth & Sci Univ, Knight Canc Inst, Adult Blood & Marrow Stem Cell Transplant Program, Portland, OR 97201 USA.
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- Sobecks, Ronald (author)
- Cleveland Clin Fdn, Dept Hematol & Med Oncol, 9500 Euclid Ave, Cleveland, OH 44195 USA.
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- Popat, Uday (author)
- Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat, Houston, TX 77030 USA.
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- Alyea, Edwin (author)
- Dana Farber Canc Inst, Ctr Hematol Oncol, Boston, MA 02115 USA.
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- Saber, Wael (author)
- Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA.
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Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA;Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA. Med Coll Wisconsin, Dept Med, Ctr Int Blood & Marrow Transplant Res, Milwaukee, WI 53226 USA. (creator_code:org_t)
- ELSEVIER SCIENCE INC, 2017
- 2017
- English.
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In: Biology of blood and marrow transplantation. - : ELSEVIER SCIENCE INC. - 1083-8791 .- 1523-6536. ; 23:5, s. 767-775
- Related links:
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http://www.bbmt.org/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Allogeneic hematopoietic cell transplantation (HCT) is potentially curative for patients with chronic myelomonocytic leukemia (CMML); however, few data exist regarding prognostic factors and transplantation outcomes. We performed this retrospective study to identify prognostic factors for post-transplantation outcomes. The CMML-specific prognostic scoring system (CPSS) has been validated in subjects receiving nontransplantation therapy and was included in our study. From 2001 to 2012, 209 adult subjects who received HCT for CMML were reported to the Center for International Blood and Marrow Transplant Research. The median age at transplantation was 57 years (range, 23 to 74). Median follow-up was 51 months (range, 3 to 122). On multivariate analyses, CPSS scores, Karnofsky performance status (KPS), and graft source were significant predictors of survival (P = .004, P = .01, P = .01, respectively). Higher CPSS scores were not associated with disease-free survival, relapse, or transplantation-related mortality. In a restricted analysis of subjects with relapse after HCT, those with intermediate-2/high risk had a nearly 2-fold increased risk of death after relapse compared to those with low/intermediate-1 CPSS scores. Respective 1-year, 3-year, and 5-year survival rates for low/intermediate-1 risk subjects were 61% (95% confidence interval [CI], 52% to 72%), 48% (95% CI, 37% to 59%), and 44% (95% CI, 33% to 55%), and for intermediate-2/high risk subjects were 38% (95% CI, 28% to 49%), 32% (95% CI, 21% to 42%), and 19% (95% CI, 8% to 29%). We conclude that higher CPSS score at time of transplantation, lower KPS, and a bone marrow graft are associated with inferior survival after HCT. Further investigation of CMML disease-related biology may provide insights into other risk factors predictive of post-transplantation outcomes. (C) 2017 American Society for Blood and Marrow Transplantation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Keyword
- Chronic myelomonocytic leukemia
- Allogeneic hematopoietic cell transplantation
- Transplantation outcomes
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Liu, Hien Duong
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Ahn, Kwang Woo
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Hu, Zhen-Huan
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Hamadani, Mehdi
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Nishihori, Taiga
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Wirk, Baldeep
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show more...
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Beitinjaneh, Ame ...
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Rizzieri, David
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Grunwald, Michae ...
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Sabloff, Mitchel ...
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Olsson, Richard ...
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Bajel, Ashish
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Bredeson, Christ ...
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Daly, Andrew
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Inamoto, Yoshihi ...
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Majhail, Navneet
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Saad, Ayman
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Gupta, Vikas
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Gerds, Aaron
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Malone, Adriana
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Tallman, Martin
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Reshef, Ran
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Marks, David I.
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Copelan, Edward
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Gergis, Usama
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Savoie, Mary Lyn ...
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Ustun, Celaletti ...
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Litzow, Mark R.
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Cahn, Jean-Yves
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Kindwall-Keller, ...
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Akpek, Gorgun
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Savani, Bipin N.
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Aljurf, Mahmoud
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Rowe, Jacob M.
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Wiernik, Peter H ...
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Hsu, Jack W.
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Cortes, Jorge
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Kalaycio, Matt
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Maziarz, Richard
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Sobecks, Ronald
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Popat, Uday
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Alyea, Edwin
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Saber, Wael
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Hematology
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Immunology
- Articles in the publication
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Biology of blood ...
- By the university
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Uppsala University
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Karolinska Institutet