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Time to onset of bi...
Time to onset of bisphosphonate-related osteonecrosis of the jaws : a multicentre retrospective cohort study
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- Fung, P. P. L. (author)
- UCL, Univ Coll London Hosp, Eastman Dent Inst & Hosp, 256 Grays Inn Rd, London WC1X 8LD, England.
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- Bedogni, G. (author)
- Liver Res Ctr, Clin Epidemiol Unit, Trieste, Italy.
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- Bedogni, A. (author)
- Univ Verona, Dept Maxillofacial Surg, Verona, Italy.;Univ Padua, Dept Maxillofacial Surg, Padua, Italy.
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- Petrie, A. (author)
- UCL, Univ Coll London Hosp, Eastman Dent Inst & Hosp, 256 Grays Inn Rd, London WC1X 8LD, England.
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- Porter, S. (author)
- UCL, Univ Coll London Hosp, Eastman Dent Inst & Hosp, 256 Grays Inn Rd, London WC1X 8LD, England.
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- Campisi, G. (author)
- Univ Palermo, Dip Discipline Chirurg Oncol & Stomatol, Palermo, Italy.
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- Bagan, J. (author)
- Univ Valencia, Univ Gen Hosp, Dept Oral & Maxillofacial Surg, Oral Med, Valencia, Spain.
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- Fusco, V. (author)
- Osped SS Antonio & Biagio & C Arrigo, Med Oncol Unit, Dept Oncol & Haematol, Alessandria, Italy.
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- Saia, G. (author)
- Univ Padua, Dept Maxillofacial Surg, Padua, Italy.
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- Acham, S. (author)
- Med Univ Graz, Dept Oral Surg & Orthodont, Univ Clin Dent Hlth & Oral Med, Graz, Austria.
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- Musto, P. (author)
- IRCCS, Sci Direct, Referral Canc Ctr Basilicata, Potenza, Italy.
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- Petrucci, M. T. (author)
- Sapienza Univ, Dept Cellular Biotechnol & Haematol, Rome, Italy.
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- Diz, P. (author)
- Santiago de Compostela Univ, Sch Med & Dent, Santiago, Spain.
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- Colella, G. (author)
- Univ Naples 2, Dept Med Surg & Dent Specialties, Naples, Italy.
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- Mignogna, M. D. (author)
- Univ Naples Federico II, Dept Neurosci Reprod & Odontostomatol Sci, Head & Neck Clin Sect, Naples, Italy.
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- Pentenero, M. (author)
- Univ Turin, Oral Med & Oral Oncol Unit, Dept Oncol, Turin, Italy.
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- Arduino, P. (author)
- Univ Turin, CIR Dent Sch, Turin, Italy.
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- Lodi, G. (author)
- Univ Milan, Dipartimento Sci Biomed Chirurg & Odontoiatr, Milan, Italy.
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- Maiorana, C. (author)
- Univ Milan, Fdn IRCCS Policlin Ca Granda, Dipartimento Sci Biomed Chirurg & Odontoiatr, Osped Maggiore Policlin, Milan, Italy.
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- Manfredi, M. (author)
- Parma Univ, Dipartimento Sci Biomed Biotecnol & Translaz S Bi, Unit Odontostomatol, Parma, Italy.
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- Hallberg, Pär, 1974- (author)
- Uppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab
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- Wadelius, Mia (author)
- Uppsala universitet,Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab
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- Takaoka, K. (author)
- Hyogo Coll Med, Dept Oral & Maxillofacial Surg, Nishinomiya, Hyogo, Japan.
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- Leung, Y. Y. (author)
- Univ Hong Kong, Oral & Maxillofacial Surg, Fac Dent, Hong Kong, Hong Kong, Peoples R China.
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- Bonacina, R. (author)
- Osped Papa Giovanni XXIII, Dept Dent, Bergamo, Italy.
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- Schiodt, M. (author)
- Copenhagen Univ Hosp, Dept Oral & Maxillofacial Surg, Rigshosp, Copenhagen, Denmark.
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- Lakatos, P. (author)
- Semmelweis Univ, Dept Med 1, Sch Med, Budapest, Hungary.
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- Taylor, T. (author)
- Kings Coll Hosp London, Dept Oral Surg, London, England.
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- De Riu, G. (author)
- Univ Hosp Sassari, Dept Maxillofacial Surg, Sassari, Italy.
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- Favini, G. (author)
- San Francesco Hosp, Dept Dent, Nuoro, Italy.
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- Rogers, S. N. (author)
- Aintree Univ Hosp NHS Fdn Trust, Liverpool, Merseyside, England.
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- Pirmohamed, M. (author)
- Univ Liverpool, Inst Translat Med, Liverpool, Merseyside, England.
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- Nicoletti, P. (author)
- Columbia Univ, Dept Syst Biol, New York, NY USA.
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- Fedele, S. (author)
- UCL, Univ Coll London Hosp, Eastman Dent Inst & Hosp, 256 Grays Inn Rd, London WC1X 8LD, England.;NIHR Univ Coll London Hosp, Biomed Res Ctr, London, England.
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UCL, Univ Coll London Hosp, Eastman Dent Inst & Hosp, 256 Grays Inn Rd, London WC1X 8LD, England Liver Res Ctr, Clin Epidemiol Unit, Trieste, Italy. (creator_code:org_t)
- 2017-03-06
- 2017
- English.
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In: Oral Diseases. - : WILEY. - 1354-523X .- 1601-0825. ; 23:4, s. 477-483
- Related links:
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https://air.unimi.it...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Objectives: Osteonecrosis of the jaw (ONJ) is a potentially severe adverse effect of bisphosphonates (BP). Although the risk of ONJ increases with increasing duration of BP treatment, there are currently no reliable estimates of the ONJ time to onset (TTO). The objective of this study was to estimate the TTO and associated risk factors in BP-treated patients.Subjects and Methods: Retrospective analysis of data from 22 secondary care centres in seven countries relevant to 349 patients who developed BP-related ONJ between 2004 and 2012.Results: The median (95%CI) TTO was 6.0 years in patients treated with alendronate (n=88) and 2.2years in those treated with zoledronate (n=218). Multivariable Cox regression showed that dentoalveolar surgery was inversely associated, and the use of antiangiogenics directly associated, with the TTO in patients with cancer treated with zoledronate.Conclusions: The incidence of ONJ increases with the duration of BP therapy, with notable differences observed with respect to BP type and potency, route of administration and underlying disease. When data are stratified by BP type, a time of 6.0 and 2.2years of oral alendronate and intravenous zoledronate therapy, respectively, is required for 50% of patients to develop ONJ. After stratification by disease, a time of 5.3 and 2.2years of BP therapy is required for 50% of patients with osteoporosis and cancer, respectively, to develop ONJ. These findings have significant implications for the design of future clinical studies and the development of risk-reduction strategies aimed at either assessing or modulating the risk of ONJ associated with BP.
Keyword
- jaw osteonecrosis
- bisphosphonates
- breast cancer
- multiple myeloma
- prostate cancer
- osteoporosis
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Fung, P. P. L.
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Bedogni, G.
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Bedogni, A.
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Petrie, A.
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Porter, S.
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Campisi, G.
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show more...
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Bagan, J.
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Fusco, V.
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Saia, G.
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Acham, S.
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Musto, P.
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Petrucci, M. T.
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Diz, P.
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Colella, G.
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Mignogna, M. D.
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Pentenero, M.
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Arduino, P.
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Lodi, G.
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Maiorana, C.
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Manfredi, M.
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Hallberg, Pär, 1 ...
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Wadelius, Mia
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Takaoka, K.
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Leung, Y. Y.
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Bonacina, R.
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Schiodt, M.
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Lakatos, P.
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Taylor, T.
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De Riu, G.
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Favini, G.
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Rogers, S. N.
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Pirmohamed, M.
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Nicoletti, P.
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Fedele, S.
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- Articles in the publication
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Oral Diseases
- By the university
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Uppsala University