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Schizophrenia copy ...
Schizophrenia copy number variants and associative learning
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- Clifton, N.E. (författare)
- Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
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- Pocklington, A.J. (författare)
- MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK
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- Scholz, Birger, 1978- (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Rees, E. (författare)
- MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK
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- Walters, J.T.R. (författare)
- MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK
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- Kirov, G. (författare)
- MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK
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- O'Donovan, M.C. (författare)
- MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK
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- Owen, M.J. (författare)
- MRC Centre for Neuropsychiatric Genetics and Genomics, Institute of Psychological Medicine and Clinical Neurosciences, Cardiff University, Cardiff, UK
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- Wilkinson, L.S. (författare)
- School of Psychology, Cardiff University, Cardiff, UK
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- Thomas, K.L. (författare)
- School of Biosciences, Cardiff University, Cardiff, UK
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- Hall, J. (författare)
- Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, UK
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(creator_code:org_t)
- 2016-12-13
- 2017
- Engelska.
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Ingår i: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 22, s. 178-182
- Relaterad länk:
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https://doi.org/10.1...
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Large-scale genomic studies have made major progress in identifying genetic risk variants for schizophrenia. A key finding from these studies is that there is an increased burden of genomic copy number variants (CNVs) in schizophrenia cases compared with controls. The mechanism through which these CNVs confer risk for the symptoms of schizophrenia, however, remains unclear. One possibility is that schizophrenia risk CNVs impact basic associative learning processes, abnormalities of which have long been associated with the disorder. To investigate whether genes in schizophrenia CNVs impact on specific phases of associative learning we combined human genetics with experimental gene expression studies in animals. In a sample of 11 917 schizophrenia cases and 16 416 controls, we investigated whether CNVs from patients with schizophrenia are enriched for genes expressed during the consolidation, retrieval or extinction of associative memories. We show that CNVs from cases are enriched for genes expressed during fear extinction in the hippocampus, but not genes expressed following consolidation or retrieval. These results suggest that CNVs act to impair inhibitory learning in schizophrenia, potentially contributing to the development of core symptoms of the disorder.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Schizophrenia
- Molekylär medicin
- Molecular Medicine
- Neurology
- Neurologi
- Medical Science
- Medicinsk vetenskap
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Clifton, N.E.
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Pocklington, A.J ...
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Scholz, Birger, ...
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Rees, E.
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Walters, J.T.R.
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Kirov, G.
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visa fler...
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O'Donovan, M.C.
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Owen, M.J.
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Wilkinson, L.S.
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Thomas, K.L.
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Hall, J.
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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Molecular Psychi ...
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Uppsala universitet