Sökning: WFRF:(Malmström Per Uno) >
FGFR3, TERT and OTX...
FGFR3, TERT and OTX1 as a Urinary Biomarker Combination for Surveillance of Patients with Bladder Cancer in a Large Prospective Multicenter Study
-
- Beukers, Willemien (författare)
- Erasmus MC, Dept Pathol, POB 2040, NL-3000 CA Rotterdam, Netherlands.
-
- van der Keur, Kirstin A. (författare)
- Erasmus MC, Dept Pathol, POB 2040, NL-3000 CA Rotterdam, Netherlands.
-
- Kandimalla, Raju (författare)
- Erasmus MC, Dept Pathol, POB 2040, NL-3000 CA Rotterdam, Netherlands.
-
visa fler...
-
- Vergouwe, Yvonne (författare)
- Erasmus MC, Dept Publ Hlth, Rotterdam, Netherlands.
-
- Steyerberg, Ewout W. (författare)
- Erasmus MC, Dept Publ Hlth, Rotterdam, Netherlands.
-
- Boormans, Joost L. (författare)
- Erasmus MC, Dept Urol, Rotterdam, Netherlands.
-
- Jensen, Jorgen B. (författare)
- Aarhus Univ Hosp, Dept Urol, Aarhus, Denmark.
-
- Lorente, Jose A. (författare)
- Hosp del Mar, Serv Urol, Barcelona, Spain.
-
- Real, Francisco X. (författare)
- Univ Pompeu Fabra, Dept Ciencies Expt & Salut, Barcelona, Spain.;Spanish Natl Canc Res Centre CNIO, Canc Cell Biol Programme, Epithelial Carcinogenesis Grp, Madrid, Spain.
-
- Segersten, Ulrike (författare)
- Uppsala universitet,Urologkirurgi
-
- Orntoft, Torben F. (författare)
- Aarhus Univ Hosp, Dept Mol Med, Aarhus, Denmark.
-
- Malats, Nuria (författare)
- Spanish Natl Canc Res Centre CNIO, Canc Cell Biol Programme, Epithelial Carcinogenesis Grp, Madrid, Spain.
-
- Malmström, Per-Uno (författare)
- Uppsala universitet,Urologkirurgi
-
- Dyrskjot, Lars (författare)
- Aarhus Univ Hosp, Dept Mol Med, Aarhus, Denmark.
-
- Zwarthoff, Ellen C. (författare)
- Erasmus MC, Dept Pathol, POB 2040, NL-3000 CA Rotterdam, Netherlands.
-
visa färre...
-
Erasmus MC, Dept Pathol, POB 2040, NL-3000 CA Rotterdam, Netherlands Erasmus MC, Dept Publ Hlth, Rotterdam, Netherlands. (creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2017
- 2017
- Engelska.
-
Ingår i: Journal of Urology. - : Ovid Technologies (Wolters Kluwer Health). - 0022-5347 .- 1527-3792. ; 197:6, s. 1410-1418
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Purpose: Patients with nonmuscle invasive bladder cancer are followed with frequent cystoscopies. In this study FGFR3, TERT and OTX1 were investigated as a diagnostic urinary marker combination during followup of patients with primary nonmuscle invasive bladder cancer.Materials and Methods: In this international, multicenter, prospective study 977 patients with nonmuscle invasive bladder cancer were included. A total of 2,496 urine samples were collected prior to cystoscopy during regular visits. Sensitivity was estimated to detect concomitant recurrences. Kaplan-Meier curves were used to estimate the development of future recurrences after urinalysis and a negative cystoscopy.Results: Sensitivity of the assay combination for recurrence detection was 57% in patients with primary low grade, nonmuscle invasive bladder cancer. However, sensitivity was 83% for recurrences that were pT1 or muscle invasive bladder cancer. Of the cases 2% progressed to muscle invasive bladder cancer. Sensitivity for recurrence detection in patients with primary high grade disease was 72% and 7% of them had progression to muscle invasive bladder cancer. When no concomitant tumor was found by cystoscopy, positive urine samples were more frequently followed by a recurrence over time compared to a negative urine sample (58% vs 36%, p < 0.001). High stage recurrences were identified within 1 year after a positive urine test and a negative cystoscopy.Conclusions: Recurrences in patients with primary nonmuscle invasive bladder cancer can be detected by a combination of urine assays. This study supports the value of urinalysis as an alternative diagnostic tool in patients presenting with low grade tumors and as a means to identify high stage tumors earlier.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Nyckelord
- urinary bladder neoplasms
- neoplasm recurrence
- local
- urinalysis
- cystoscopy
- neoplasm invasiveness
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Beukers, Willemi ...
-
van der Keur, Ki ...
-
Kandimalla, Raju
-
Vergouwe, Yvonne
-
Steyerberg, Ewou ...
-
Boormans, Joost ...
-
visa fler...
-
Jensen, Jorgen B ...
-
Lorente, Jose A.
-
Real, Francisco ...
-
Segersten, Ulrik ...
-
Orntoft, Torben ...
-
Malats, Nuria
-
Malmström, Per-U ...
-
Dyrskjot, Lars
-
Zwarthoff, Ellen ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Urologi och njur ...
- Artiklar i publikationen
-
Journal of Urolo ...
- Av lärosätet
-
Uppsala universitet