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Plasma 1-deoxysphin...
Plasma 1-deoxysphingolipids are early predictors of incident type 2 diabetes mellitus
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- Mwinyi, Jessica (författare)
- Uppsala universitet,Funktionell farmakologi
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- Boström, Adrian (författare)
- Uppsala universitet,Funktionell farmakologi
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- Fehrer, I. (författare)
- Univ Zurich, Inst Clin Chem, Zurich, Switzerland.;Univ Hosp Zurich, Zurich, Switzerland.
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- Othman, A. (författare)
- Univ Zurich, Inst Clin Chem, Zurich, Switzerland.;Univ Hosp Zurich, Zurich, Switzerland.
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- Waeber, G. (författare)
- Univ Lausanne, Lausanne Univ Hosp CHUV, Dept Med, Lausanne, Switzerland.;Univ Lausanne, Fac Biol & Med, Lausanne, Switzerland.
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- Marti-Soler, H. (författare)
- Univ Lausanne, Lausanne Univ Hosp CHUV, Dept Med, Lausanne, Switzerland.;Univ Lausanne, Fac Biol & Med, Lausanne, Switzerland.
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- Vollenweider, P. (författare)
- Univ Lausanne, Lausanne Univ Hosp CHUV, Dept Med, Lausanne, Switzerland.;Univ Lausanne, Fac Biol & Med, Lausanne, Switzerland.
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- Marques-Vidal, P. (författare)
- Univ Lausanne, Lausanne Univ Hosp CHUV, Dept Med, Lausanne, Switzerland.;Univ Lausanne, Fac Biol & Med, Lausanne, Switzerland.
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- Schiöth, Helgi B. (författare)
- Uppsala universitet,Funktionell farmakologi
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- von Eckardstein, A. (författare)
- Univ Zurich, Inst Clin Chem, Zurich, Switzerland.;Univ Hosp Zurich, Zurich, Switzerland.
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- Hornemann, T. (författare)
- Univ Zurich, Inst Clin Chem, Zurich, Switzerland.;Univ Hosp Zurich, Zurich, Switzerland.
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(creator_code:org_t)
- 2017-05-04
- 2017
- Engelska.
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Ingår i: PLOS ONE. - : PUBLIC LIBRARY SCIENCE. - 1932-6203. ; 12:5
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://journals.plo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- 1-Deoxysphingolipids (1-deoxySLs) are atypical sphingolipids, which are formed in a side reaction during sphingolipid de-novo synthesis. Recently, we demonstrated that 1-deoxySLs are biomarkers for the prediction of T2DM in obese, non-diabetic patients. Here we investigated the relevance of 1-deoxySLs as long-term predictive biomarkers for the incidence of T2DM in an asymptomatic population. Here, we analyzed the plasma sphingoid base profile in a nested group of non-diabetic individuals (N = 605) selected from a population- based study including 5 year follow-up data (CoLaus study). 1-DeoxySLs at baseline were significantly elevated in individuals who developed T2DM during the follow-up (p<0.001), together with increased glucose (p<5.11E-14), triglycerides (p<0.001)and HOMA-IR indices (p<0.001). 1-Deoxy-sphinganine (1-deoxySA) and 1-deoxy-sphingosine (1-deoxySO) were predictive for T2DM, even after adjusting for fasting glucose levels in the binary regression analyses. The predictive value of the combined markers 1-deoxySA+ glucose were superior to glucose alone in normal-weight subjects (p<0.001) but decreased substantially with increasing BMI. Instead, plasma adiponectin and waist-to-hip ratio appeared to be better risk predictors for obese individuals (BMI>30kg/m(2)). In conclusion, elevated plasma 1-deoxySL levels are strong and independent risk predictors of future T2DM, especially for non-obese individuals in the general population.
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Mwinyi, Jessica
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Boström, Adrian
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Fehrer, I.
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Othman, A.
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Waeber, G.
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Marti-Soler, H.
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visa fler...
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Vollenweider, P.
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Marques-Vidal, P ...
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Schiöth, Helgi B ...
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von Eckardstein, ...
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Hornemann, T.
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Uppsala universitet