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Equal clinical perf...
Equal clinical performance of a novel point-of-care cardiac troponin I (cTnI) assay with a commonly used high-sensitivity cTnI assay
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- Venge, Per (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper
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- van Lippen, Lian (författare)
- Philips Handheld Diagnost, Eindhoven, Netherlands.
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- Blaschke, Sabine (författare)
- Univ Med Ctr Gottingen, Interdisciplinary Emergency Care Unit, Gottingen, Germany.
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- Christ, Michael (författare)
- Luzerner Kantonsspital, Emergency Dept, Luzern, Switzerland.;Paracelsus Med Univ, Nuernberg Gen Hosp, Dept Emergency & Crit Care Med, Nurnberg, Germany.
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- Geier, Felicitas (författare)
- Paracelsus Med Univ, Nuernberg Gen Hosp, Dept Emergency & Crit Care Med, Nurnberg, Germany.
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- Giannitsis, Evangelos (författare)
- Heidelberg Univ, Med Klin 3, Heidelberg, Germany.
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- Hagström, Emil (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Hausfater, Pierre (författare)
- Hop La Pitie Salpetriere, AP HP, Emergency Dept, Paris, France.;UPMC Univ Paris 06, Sorbonne Univ, GRC BIOSFAST 14, Paris, France.
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- Khellaf, Mehdi (författare)
- Hop Henri Mondor, Emergency Dept, Creteil, France.
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- Mair, Johannes (författare)
- Innsbruck Med Univ, Dept Internal Med Cardiol & Angiol 3, Innsbruck, Austria.
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- Pariente, David (författare)
- Hop La Pitie Salpetriere, AP HP, Emergency Dept, Paris, France.
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- Scharnhorst, Volkher (författare)
- Catharina Ziekenhuis Eindhoven, Clin Lab, Eindhoven, Netherlands.;Tech Univ Eindhoven, Eindhoven, Netherlands.
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- Semjonow, Veronique (författare)
- Philips Handheld Diagnost, Eindhoven, Netherlands.
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(creator_code:org_t)
- ELSEVIER SCIENCE BV, 2017
- 2017
- Engelska.
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Ingår i: Clinica Chimica Acta. - : ELSEVIER SCIENCE BV. - 0009-8981 .- 1873-3492. ; 469, s. 119-125
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Efficient rule-out of acute myocardial infarction (MI) facilitates early disposition of chest pain patients in emergency departments (ED). Point-of-care (POC) cardiac troponin (cTn) may improve patient throughput. We compared the diagnostic accuracy of a novel cTnI test (Minicare cTnI, Philips), with current POC cTnI (I-Stat, Abbott) and high-sensitivity central laboratory cTnI (hs-cTnI; Architect, Abbott) assays.Methods: The clinical performance of the assays were compared in samples from 450 patients from a previous clinical evaluation of Minicare cTnI.Results: Minicare cTnI correlated with Architect hs-cTnI (r(2) = 0.85, p < 0.0001) and I-Stat cTnI (r(2) = 0.93, p < 0.0001). Areas under the receiver operating characteristics curves were 0.87-0.91 at admission (p = ns) and 0.96-0.97 3 h after admission (p = ns). The negative predictive values (NPV) at admission were 95% ((92-97%, 95% CI) for Minicare cTnI and increased to 99% (97-100%) at 2-4 h, and similar to Architect hs-cTnI (98%, 96-100%), but higher than I-Stat cTnI (95%, 92-97%; p < 0.01). Negative likelihood ratios (LR) after 2-4 h were 0.06 (0.02-0.17, 95% CI) for Minicare cTnI, 0.11 (0.05-0.24) for Architect hs-cTnI (p = 0.02) and 0.28 (0.18-0.43) for I-Stat cTnI (p < 0.0001). The clinical concordances between Minicare cTnI and Architect hs-cTnI were 92% (admission) and 95% (2-4 h), with lower concordances between Minicare cTnI and I-Stat cTnI (83% and 78%, respectively; p = 0.007).Conclusions: The Minicare cTnI POC assay may become useful for prompt and safe ruling-out of AMI in ED patients with suspected AMI using a guideline supported 0/3 h sampling protocol.
Nyckelord
- Cardiac troponin I
- Acute myocardial infarction
- Point-of-care
- Emergency medicine
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Venge, Per
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van Lippen, Lian
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Blaschke, Sabine
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Christ, Michael
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Geier, Felicitas
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Giannitsis, Evan ...
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Hagström, Emil
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Hausfater, Pierr ...
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Khellaf, Mehdi
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Mair, Johannes
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Pariente, David
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Scharnhorst, Vol ...
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Semjonow, Veroni ...
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Clinica Chimica ...
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Uppsala universitet