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Ten-year outcomes o...
Ten-year outcomes of a randomised trial of laparoscopic versus open surgery for colon cancer
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- Deijen, Charlotte L. (författare)
- Vrije Univ Amsterdam
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- Vasmel, Jeanine E. (författare)
- Vrije Univ Amsterdam
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- de Lange-de Klerk, Elly S. M. (författare)
- Vrije Univ Amsterdam
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- Cuesta, Miguel A. (författare)
- Vrije Univ Amsterdam
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- Coene, Peter-Paul L. O. (författare)
- Maasstad Hosp, Rotterdam, Netherlands.
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- Lange, Johan F. (författare)
- Erasmus MC, Rotterdam, Netherlands.
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- Meijerink, W. J. H. Jeroen (författare)
- Vrije Univ Amsterdam
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- Jakimowicz, Jack J. (författare)
- Delft Univ Technol
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- Jeekel, Johannes (författare)
- Erasmus MC, Dept Surg, Rotterdam
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- Kazemier, Geert (författare)
- Vrije Univ Amsterdam
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- Janssen, Ignace M. C. (författare)
- Rijnstate Hosp, Dept Surg, Arnhem
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- Påhlman, Lars (författare)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper
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- Haglind, Eva (författare)
- Sahlgrens Univ Hosp
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- Bonjer, H. Jaap (författare)
- Vrije Univ Amsterdam
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Vrije Univ Amsterdam Maasstad Hosp, Rotterdam, Netherlands (creator_code:org_t)
- 2016-10-12
- 2017
- Engelska.
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Ingår i: Surgical Endoscopy. - : SPRINGER. - 0930-2794 .- 1432-2218. ; 31:6, s. 2607-2615
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://link.springe...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Laparoscopic surgery for colon cancer is associated with improved recovery and similar cancer outcomes at 3 and 5 years in comparison with open surgery. However, long-term survival rates have rarely been reported. Here, we present survival and recurrence rates of the Dutch patients included in the COlon cancer Laparoscopic or Open Resection (COLOR) trial at 10-year follow-up. Between March 1997 and March 2003, patients with non-metastatic colon cancer were recruited by 29 hospitals in eight countries and randomised to either laparoscopic or open surgery. Main inclusion criterion for the COLOR trial was solitary adenocarcinoma of the left or right colon. The primary outcome was disease-free survival at 3 years, and secondary outcomes included overall survival and recurrence. The 10-year follow-up data of all Dutch patients were collected. Analysis was by intention-to-treat. The trial was registered at ClinicalTrials.gov (NCT00387842). In total, 1248 patients were randomised, of which 329 were Dutch. Fifty-eight Dutch patients were excluded and 15 were lost to follow-up, leaving 256 patients for 10-year analysis. Median follow-up was 112 months. Disease-free survival rates were 45.2 % in the laparoscopic group and 43.2 % in the open group (difference 2.0 %; 95 % confidence interval (CI) -10.3 to 14.3; p = 0.96). Overall survival rates were 48.4 and 46.7 %, respectively (difference 1.7 %; 95 % CI -10.6 to 14.0; p = 0.83). Stage-specific analysis revealed similar survival rates for both groups. Sixty-two patients were diagnosed with recurrent disease, accounting for 29.4 % in the laparoscopic group and 28.2 % in the open group (difference 1.2 %; 95 % CI -11.1 to 13.5; p = 0.73). Seven patients had port- or wound-site recurrences (laparoscopic n = 3 vs. open n = 4). Laparoscopic surgery for non-metastatic colon cancer is associated with similar rates of disease-free survival, overall survival and recurrences as open surgery at 10-year follow-up.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- Colon cancer
- Surgery
- Laparoscopic
- Treatment
- Randomised clinical trial
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Deijen, Charlott ...
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Vasmel, Jeanine ...
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de Lange-de Kler ...
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Cuesta, Miguel A ...
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Coene, Peter-Pau ...
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Lange, Johan F.
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Meijerink, W. J. ...
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Jakimowicz, Jack ...
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Jeekel, Johannes
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Kazemier, Geert
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Janssen, Ignace ...
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Påhlman, Lars
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Haglind, Eva
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Bonjer, H. Jaap
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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Surgical Endosco ...
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Uppsala universitet