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Sökning: (WFRF:(Brazauskas Ruta)) > (2017) > Long-Term Outcome o...

  • Cheng, Yee ChungMed Coll Wisconsin, Milwaukee, WI 53226 USA (författare)

Long-Term Outcome of Inflammatory Breast Cancer Compared to Non-Inflammatory Breast Cancer in the Setting of High-Dose Chemotherapy with Autologous Hematopoietic Cell Transplantation

  • Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • IVYSPRING INT PUBL,2017
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-328284
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-328284URI
  • https://doi.org/10.7150/jca.16870DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:135987915URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Introduction: Inflammatory breast cancer (IBC) is a rare aggressive form of breast cancer. It is well known that the long-term survival and progression-free survival of IBC are worse than that of non-IBC. We report the long term outcomes of patients with IBC and non-IBC who had undergone high-dose chemotherapy (HDC) with autologous hematopoietic cell transplantation (AHCT).Methods: All 3387 patients with IBC or non-IBC who underwent HDC with AHCT between1990-2002 and registered with CIBMTR were included in this analysis. Transplant-related mortality (TRM), disease relapse/progression, progression-free survival (PFS) and overall survival (OS) were compared between the two cohorts. Multivariate Cox regression model was used to determine the independent impact of stage on outcomes.Results: 527 patients with IBC and 2,860 patients with non-IBC were included; the median age at transplantation (47 vs 46 years old) and median follow-up period in the 2 groups (167 vs 168 months) were similar. The most common conditioning regimen was cyclophosphamide and carboplatin based in both groups (54% in IBC and 50% in non-IBC). AHCT was well tolerated in both groups. TRM was similar in both groups (one year TRM was 2% for IBC and 3% for non-IBC, p= 0.16). The most common cause of death was disease progression or relapse (81% in IBC and 75% in non-IBC). The median survival for both IBC and non-IBC was the same at 40 months. The PFS at 10 years was 27% (95% CI: 23-31%) for IBC and 24% (95% CI: 22-26%) for non-IBC (p= 0.21), and the OS at 10 years was 31% (95% CI: 27-35%) for IBC and 28% (95% CI: 26-30%) for non-IBC (p= 0.16). In univariate analysis, patients with stage III IBC and no active diseases at transplantation had lower PFS and OS than that in non-IBC. In multivariate analysis, controlling for age, disease status at AHCT, hormonal receptor status, time from HR 1.16, 95% CI: 1- 1.34, p=0.0459), worse PFS (HR: 1.17, 95% CI: 1.01-1.36, p= 0.0339) and higher risk of disease relapse/progression (HR: 1.24, 95% CI: 1.06- 1.45, p= 0.0082) as compared to stage III non-IBC. Amongst all patients a higher stage disease was associated with worse PFS, OS and disease relapse/ progression.Conclusions: Long-term outcomes of stage III IBC patients who underwent AHCT were poorer than that in non-IBC patients confirming that the poor prognosis of IBC even in the setting of HDC with AHCT.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Shi, YushuMed Coll Wisconsin, Milwaukee, WI 53226 USA. (författare)
  • Zhang, Mei-JieMed Coll Wisconsin, Milwaukee, WI 53226 USA.;Med Coll Wisconsin, Milwaukee, WI 53226 USA. (författare)
  • Brazauskas, RutaMed Coll Wisconsin, Milwaukee, WI 53226 USA. (författare)
  • Hemmer, Michael T.Med Coll Wisconsin, Milwaukee, WI 53226 USA. (författare)
  • Bishop, Michael R.Univ Chicago Hosp, Chicago, IL 60637 USA. (författare)
  • Nieto, YagoUniv Texas, Houston, TX 77030 USA. (författare)
  • Stadtmauer, EdwardUniv Penn, Philadelphia, PA 19104 USA. (författare)
  • Ayash, LoisKarmanos Canc Inst, Detroit, MI USA.;Univ Minnesota, Minneapolis, MN 55455 USA. (författare)
  • Gale, Robert PeterImperial Coll London, London, England. (författare)
  • Lazarus, HillardUniv Hosp, Cleveland, OH USA. (författare)
  • Holmberg, LeonaFred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA. (författare)
  • Lill, MichaelCedars Sinai Med Ctr, Los Angeles, CA 90048 USA. (författare)
  • Olsson, RKarolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Stockholm, Sweden.(Swepub:uu)riols677 (författare)
  • Wirk, Baldeep MonaSeattle Canc Care Alliance, Seattle, WA USA. (författare)
  • Arora, MuktaUniv Minnesota, Minneapolis, MN 55455 USA. (författare)
  • Hari, ParameswaranMed Coll Wisconsin, Milwaukee, WI 53226 USA. (författare)
  • Ueno, NaotoUniv Texas, Houston, TX 77030 USA. (författare)
  • Med Coll Wisconsin, Milwaukee, WI 53226 USAMed Coll Wisconsin, Milwaukee, WI 53226 USA. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Cancer: IVYSPRING INT PUBL8:6, s. 1009-10171837-9664

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