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WFRF:(Varghese Oommen P. 1977 )
 

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  • Wang, ShujiangUppsala universitet,Polymerkemi (author)

Saline catalyse oxime reaction at physiological pH : overcoming a major limitation of bioorthogonal reaction

  • Article/chapterEnglish

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  • LIBRIS-ID:oai:DiVA.org:uu-328905
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-328905URI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • We have discovered a simple and versatile reaction condition for oxime mediated bioconjugation reaction that could be adapted for both aldehyde and keto substrates. We found that saline accelerated the oxime kinetics in a concentration dependent manner under physiological conditions. The reaction mechanism is validated by computational studies, and the versatility of the reaction is demonstrated by cell-surface labeling experiments. Saline offers an efficient and non-toxic catalytic option for performing the bioorthogonal-coupling reaction of biomolecules at the physiological pH. This saline mediated bioconjugation reaction represents the most bio-friendly, mild and versatile approach for conjugating sensitive biomolecules and does not require any extensive purification step.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Nawale, Ganesh N.Uppsala universitet,Polymerkemi(Swepub:uu)ganna194 (author)
  • Kadekar, SandeepUppsala universitet,Polymerkemi(Swepub:uu)sanka861 (author)
  • Oommen, Oommen P.Tampere University of Technology, and BioMediTech Institute, Finland (author)
  • Jena, Naresh K.Uppsala universitet,Materialteori(Swepub:uu)narje540 (author)
  • Chakraborty, SudipUppsala universitet,Materialteori(Swepub:uu)sudch599 (author)
  • Hilborn, Jöns,1956-Uppsala universitet,Polymerkemi(Swepub:uu)johil255 (author)
  • Varghese, Oommen P.,1977-Uppsala universitet,Polymerkemi(Swepub:uu)oopva021 (author)
  • Uppsala universitetPolymerkemi (creator_code:org_t)

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