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Human gut microbes ...
Human gut microbes impact host serum metabolome and insulin sensitivity
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- Pedersen, Helle Krogh (författare)
- Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland
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- Gudmundsdottir, Valborg (författare)
- Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark, Kongens Lyngby, Denmark
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- Nielsen, Henrik Bjorn (författare)
- Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark, Kongens Lyngby, Denmark
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- Hyötyläinen, Tuulia, 1971- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Turku Centre for Biotechnology, Åbo Akademi University, Turku, Finland; Turku Centre for Biotechnology, University of Turku, Turku, Finland; VTT Technical Research Centre of Finland, Espoo, Finland
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- Nielsen, Trine (författare)
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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- Jensen, Benjamin A. H. (författare)
- Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark
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- Forslund, Kristoffer (författare)
- European Molecular Biology Laboratory, Heidelberg, Germany
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- Hildebrand, Falk (författare)
- European Molecular Biology Laboratory, Heidelberg, Germany; Department of Bioscience Engineering, Vrije Universiteit Brussel, Brussels, Belgium; Center for the Biology of Disease, VIB, Leuven, Belgium
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- Prifti, Edi (författare)
- MGP MetaGénoPolis, INRA, Université Paris-Saclay, Jouy en Josas, France; Institute of Cardiometabolism and Nutrition (ICAN), Paris, France
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- Falony, Gwen (författare)
- Center for the Biology of Disease, VIB, Leuven, Belgium; Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium
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- Le Chatelier, Emmanuelle (författare)
- MGP MetaGénoPolis, INRA, Université Paris-Saclay, Jouy en Josas, France
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- Levenez, Florence (författare)
- MGP MetaGénoPolis, INRA, Université Paris-Saclay, Jouy en Josas, France
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- Dore, Joel (författare)
- MGP MetaGénoPolis, INRA, Université Paris-Saclay, Jouy en Josas, France; Micalis Institute, INRA, AgroParisTech, Université Paris-Saclay, Jouy-en-Josas, France
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- Mattila, Ismo (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland; Steno Diabetes Center, Gentofte, Denmark
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- Plichta, Damian R. (författare)
- Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark, Kongens, Lyngby, Denmark
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- Pöhö, Paivi (författare)
- VTT Technical Research Centre of Finland, Espoo, Finland; Faculty of Pharmacy, University of Helsinki, Helsinki, Finland
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- Hellgren, Lars I. (författare)
- Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark, Kongens, Lyngby, Denmark
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- Arumugam, Manimozhiyan (författare)
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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- Sunagawa, Shinichi (författare)
- European Molecular Biology Laboratory, Heidelberg, Germany; Institute of Microbiology, ETH Zurich, Zurich, Switzerland
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- Vieira-Silva, Sara (författare)
- Center for the Biology of Disease, VIB, Leuven, Belgium; Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium
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- Jørgensen, Torben (författare)
- Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Research Centre for Prevention and Health, Centre for Health, Capital Region, Glostrup Hospital, Glostrup, Denmark
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- Holm, Jacob Bak (författare)
- Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark
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- Trost, Kajetan (författare)
- Steno Diabetes Center, Gentofte, Denmark
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- Kristiansen, Karsten (författare)
- Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark; BGI-Shenzhen, Shenzhen, China
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- Brix, Susanne (författare)
- Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark, Kongens, Lyngby, Denmark
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- Raes, Jeroen (författare)
- Department of Bioscience Engineering, Vrije Universiteit Brussel, Brussels, Belgium; Center for the Biology of Disease, VIB, Leuven, Belgium; Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium
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- Wang, Jun (författare)
- Laboratory of Genomics and Molecular Biomedicine, Department of Biology, University of Copenhagen, Copenhagen, Denmark; BGI-Shenzhen, Shenzhen, China; Princess Al Jawhara Albrahim Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University, Jeddah, Saudi Arabia; Macau University of Science and Technology, Taipa, China; Department of Medicine and State Key Laboratory of Pharmaceutical Biotechnology, University of Hong Kong, Hong Kong, China
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- Hansen, Torben (författare)
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark
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- Bork, Peer (författare)
- European Molecular Biology Laboratory, Heidelberg, Germany; Molecular Medicine Partnership Unit, University of Heidelberg and European Molecular Biology Laboratory, Heidelberg, Germany; Max Delbrück Centre for Molecular Medicine, Berlin, Germany; Department of Bioinformatics, University of Wuerzburg, Würzburg, Germany
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- Brunak, Søren (författare)
- Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark, Kongens, Lyngby, Denmark; Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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- Oresic, Matej, 1967- (författare)
- Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland; VTT Technical Research Centre of Finland, Espoo, Finland; Steno Diabetes Center, Gentofte, Denmark
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- Ehrlich, S. Dusko (författare)
- Center for Biological Sequence Analysis, Dept. of Systems Biology, Technical University of Denmark, Kongens Lyngby, Denmark; University of Örebro, Örebro, Sweden
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- Pedersen, Oluf (författare)
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
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Novo Nordisk Foundation Center for Protein Research, Disease Systems Biology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland Center for Biological Sequence Analysis, Dept of Systems Biology, Technical University of Denmark, Kongens Lyngby, Denmark (creator_code:org_t)
- 2016-07-13
- 2016
- Engelska.
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Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 535:7612, s. 376-381
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Insulin resistance is a forerunner state of ischaemic cardiovascular disease and type 2 diabetes. Here we show how the human gut microbiome impacts the serum metabolome and associates with insulin resistance in 277 non-diabetic Danish individuals. The serum metabolome of insulin-resistant individuals is characterized by increased levels of branched-chain amino acids (BCAAs), which correlate with a gut microbiome that has an enriched biosynthetic potential for BCAAs and is deprived of genes encoding bacterial inward transporters for these amino acids. Prevotella copri and Bacteroides vulgatus are identified as the main species driving the association between biosynthesis of BCAAs and insulin resistance, and in mice we demonstrate that P. copri can induce insulin resistance, aggravate glucose intolerance and augment circulating levels of BCAAs. Our findings suggest that microbial targets may have the potential to diminish insulin resistance and reduce the incidence of common metabolic and cardiovascular disorders.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
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Pedersen, Helle ...
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Gudmundsdottir, ...
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Nielsen, Henrik ...
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Hyötyläinen, Tuu ...
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Nielsen, Trine
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Jensen, Benjamin ...
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Forslund, Kristo ...
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Hildebrand, Falk
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Prifti, Edi
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Falony, Gwen
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Le Chatelier, Em ...
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Levenez, Florenc ...
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Dore, Joel
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Mattila, Ismo
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Plichta, Damian ...
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Pöhö, Paivi
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Hellgren, Lars I ...
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Arumugam, Manimo ...
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Sunagawa, Shinic ...
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Vieira-Silva, Sa ...
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Jørgensen, Torbe ...
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Holm, Jacob Bak
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Trost, Kajetan
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Kristiansen, Kar ...
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Brix, Susanne
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Raes, Jeroen
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Wang, Jun
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Hansen, Torben
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Bork, Peer
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Brunak, Søren
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Oresic, Matej, 1 ...
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Ehrlich, S. Dusk ...
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Pedersen, Oluf
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Örebro universitet