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  • Wibroe, MortenRigshosp, Dept Neurosurg, Copenhagen, Denmark.;Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.,Copenhagen University Hospital (författare)

Cerebellar mutism syndrome in children with brain tumours of the posterior fossa

  • Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • 2017-06-21
  • BIOMED CENTRAL LTD,2017
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-329654
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-329654URI
  • https://doi.org/10.1186/s12885-017-3416-0DOI
  • https://lup.lub.lu.se/record/3b94fe51-5ede-44c7-b145-50a32f25b51bURI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:136056137URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Central nervous system tumours constitute 25% of all childhood cancers; more than half are located in the posterior fossa and surgery is usually part of therapy. One of the most disabling late effects of posterior fossa tumour surgery is the cerebellar mutism syndrome (CMS) which has been reported in up to 39% of the patients but the exact incidence is uncertain since milder cases may be unrecognized. Recovery is usually incomplete. Reported risk factors are tumour type, midline location and brainstem involvement, but the exact aetiology, surgical and other risk factors, the clinical course and strategies for prevention and treatment are yet to be determined.Methods: This observational, prospective, multicentre study will include 500 children with posterior fossa tumours. It opened late 2014 with participation from 20 Nordic and Baltic centres. From 2016, five British centres and four Dutch centres will join with a total annual accrual of 130 patients. Three other major European centres are invited to join from 2016/17. Follow-up will run for 12 months after inclusion of the last patient. All patients are treated according to local practice. Clinical data are collected through standardized online registration at pre-determined time points pre- and postoperatively. Neurological status and speech functions are examined pre- operatively and postoperatively at 1-4 weeks, 2 and 12 months. Pre- and postoperative speech samples are recorded and analysed. Imaging will be reviewed centrally. Pathology is classified according to the 2007 WHO system. Germline DNA will be collected from all patients for associations between CMS characteristics and host genome variants including pathway profiles.Discussion: Through prospective and detailed collection of information on 1) differences in incidence and clinical course of CMS for different patient and tumour characteristics, 2) standardized surgical data and their association with CMS, 3) diversities and results of other therapeutic interventions, and 4) the role of host genome variants, we aim to achieve a better understanding of risk factors for and the clinical course of CMS - with the ultimate goal of defining strategies for prevention and treatment of this severely disabling condition.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Cappelen, JohanSt Olavs Hosp, Dept Neurosurg, Trondheim, Norway.,St. Olav’s University Hospital (författare)
  • Castor, CharlotteLund University,Lunds universitet,Barns och familjers hälsa,Forskargrupper vid Lunds universitet,Child and Family Health,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-ccs (författare)
  • Clausen, NielsAarhus Univ Hosp, Dept Pediat, Aarhus, Denmark.,Aarhus University Hospital (författare)
  • Grillner, PernillaKarolinska Institutet (författare)
  • Gudrunardottir, ThoraPosterior Fossa Soc Https Www Posteriorfossa Org, Stockholm, Sweden.;North Zealand Hosp, Dept Oncol & Palliat, Hillerod, Denmark.,Posterior Fossa Society,Nordsjællands Hospital (författare)
  • Gupta, RamneekTech Univ Denmark, Ctr Biol Sequence Anal, Lyngby, Denmark.,Technical University of Denmark (författare)
  • Gustavsson, BengtKarolinska Univ Hosp, Dept Neurosurg, Stockholm, Sweden.,Karolinska University Hospital (författare)
  • Heyman, MatsKarolinska Institutet (författare)
  • Holm, StefanKarolinska Univ Sjukhuset, Dept Womens & Childrens Hlth, Stockholm, Sweden.,Karolinska University Hospital (författare)
  • Karppinen, AtteHelsinki Univ Hosp, Dept Neurosurg, Helsinki, Finland.,Helsinki University Central Hospital (författare)
  • Klausen, CamillaRigshosp, Univ Hosp Copenhagen, Dept Neuroradiol, Copenhagen, Denmark.,Copenhagen University Hospital (författare)
  • Lönnqvist, TuulaUniv Helsinki, Cent Hosp, Dept Child Neurol, Helsinki, Finland.,Helsinki University Central Hospital (författare)
  • Mathiasen, ReneRigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.,Copenhagen University Hospital (författare)
  • Nilsson, PelleUppsala universitet,Neurokirurgi,Uppsala University Hospital(Swepub:uu)pellnils (författare)
  • Nysom, KarstenRigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.,Copenhagen University Hospital (författare)
  • Persson, KarinLund University,Lunds universitet,Institutionen för hälsovetenskaper,Medicinska fakulteten,Department of Health Sciences,Faculty of Medicine(Swepub:lu)med-kpr (författare)
  • Rask, OlofLund University,Lunds universitet,Enheten för pediatrisk hematologi,Forskargrupper vid Lunds universitet,Paediatric Hematologic Research Group,Lund University Research Groups,Skåne University Hospital(Swepub:lu)pedi-ora (författare)
  • Schmiegelow, KjeldRigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.;Univ Copenhagen, Inst Clin Med, Copenhagen, Denmark.;Univ Langone, Med Ctr, Perlmutter Canc Ctr, Div Pediat Hematol Oncol, New York, NY USA.,Copenhagen University Hospital,University of Copenhagen (författare)
  • Sehested, AstridRigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.,Copenhagen University Hospital (författare)
  • Thomassen, HaraldSt Olavs Hosp, Dept Pediat, Trondheim, Norway.,St. Olav’s University Hospital (författare)
  • Tonning-Olsson, IngridLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Pediatrisk onkologi,Forskargrupper vid Lunds universitet,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Pediatric Oncology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)pedi-it0 (författare)
  • Zetterqvist, BarbaraKarolinska Institute (författare)
  • Juhler, MarianneRigshosp, Dept Neurosurg, Copenhagen, Denmark.;Univ Copenhagen, Inst Clin Med, Copenhagen, Denmark.,University of Copenhagen,Copenhagen University Hospital (författare)
  • Rigshosp, Dept Neurosurg, Copenhagen, Denmark.;Rigshosp, Dept Pediat & Adolescent Med, Copenhagen, Denmark.Copenhagen University Hospital (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:BMC Cancer: BIOMED CENTRAL LTD171471-2407

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