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- Zhang, YiCapital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China. (author)
Elemene inhibits the migration and invasion of 4T1 murine breast cancer cells via heparanase
- Article/chapterEnglish2017
Publisher, publication year, extent ...
- 2017-05-26
- Spandidos Publications,2017
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-330011
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-330011URI
- https://doi.org/10.3892/mmr.2017.6638DOI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- Elemene (ELE), a natural plant drug extracted from Curcumae Rhizoma, has been widely used for cancer treatment in China for more than 20 years. Although it is reported to be a broad-spectrum anticancer drug, the mechanism underlying the action of ELE in the treatment of breast cancer remains to be fully elucidated. Heparanase, a mammalian endo-D-glucuronidase, is involved in degradation of the extracellular matrix (ECM), and thus promotes tumor progression and metastasis. The downregulation of heparanase can effectively reduce tumor malignant behaviors. In the present study, the inhibitory effects of ELE were evaluated in breast cancer cells using a Cell Counting kit 8 assay. The migratory and invasive capabilities of cancer cells were investigated using a wound healing assay, real-time cell analysis and a Transwell assay. In addition, western blot analysis was used to assess alterations in the expression levels of key proteins. The present results confirmed the antiproliferative and antimetastatic effects of ELE, using low-molecular weight heparin (LMWH) as a positive control. In addition, ELE was demonstrated to downregulate the expression of heparanase, and decrease the phosphorylation of extracellular signal-regulated kinase and AKT. These findings suggested that ELE may be a promising agent targeting heparanase in the treatment of breast cancer.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine hsv//eng
- elemene
- invasion
- migration
- heparanase
- extracellular regulated kinase
- AKT
Added entries (persons, corporate bodies, meetings, titles ...)
- Sun, XuCapital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China. (author)
- Nan, NanCapital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China. (author)
- Cao, Ke-XinCapital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China. (author)
- Ma, CongCapital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China. (author)
- Yang, Guo-WangCapital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China. (author)
- Yu, Ming-WeiCapital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China. (author)
- Yang, LinCapital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China. (author)
- Li, Jin-PingUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China,Biokemi och Molekylär Cellbiologi; Jin-Ping Li(Swepub:uu)jinpili (author)
- Wang, Xiao-MinCapital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China. (author)
- Zhang, Gan-LinCapital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China. (author)
- Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China.Institutionen för medicinsk biokemi och mikrobiologi (creator_code:org_t)
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- In:Molecular Medicine Reports: Spandidos Publications16:1, s. 794-8001791-29971791-3004
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