Dog Exposure During the First Year of Life and Type 1 Diabetes in Childhood

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Wernroth, Mona-LisaUppsala universitet,Uppsala kliniska forskningscentrum (UCR),Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden; Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden (author)

Dog Exposure During the First Year of Life and Type 1 Diabetes in Childhood

Article/chapterEnglish2017

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AMER MEDICAL ASSOC,2017
printrdacarrier

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LIBRIS-ID:oai:DiVA.org:uu-330038
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-330038URI
https://doi.org/10.1001/jamapediatrics.2017.0585DOI
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-58935URI
http://kipublications.ki.se/Default.aspx?queryparsed=id:136128348URI

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Language:English
Summary in:English

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Subject category:art swepub-publicationtype

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Funding Agencies:Diabetesfonden grant DIA 2014-026Swedish Initiative for Research on Microdata in the Social and Medical Sciences 80748301 340-2013-5867
IMPORTANCE The association between early exposure to animals and type 1 diabetes in childhood is not clear. OBJECTIVE To determine whether exposure to dogs during the first year of life is associated with the development of type 1 diabetes in childhood. DESIGN, SETTING, AND PARTICIPANTS A nationwide cohort study utilizing high-quality Swedish national demographic and health registers was conducted. A total of 840 593 children born in Sweden from January 1, 2001, to December 31, 2010, were evaluated. Type 1 diabetes was identified using diagnosis codes from hospitals and dispensed prescriptions of insulin. Cox proportional hazards regression models were used to assess the association between exposure to dogs and risk of type 1 diabetes in childhood. The possible association was further investigated by performing dose-response and breed group-specific analyses. The cohort was followed up until September 30, 2012. Data analysis was conducted from October 15, 2015, to February 8, 2017. EXPOSURES Having a parent who was registered as a dog owner during the child's first year of life. MAIN OUTCOMES AND MEASURES Childhood-onset type 1 diabetes. RESULTS Of the 840 593 children reviewed, 408 272 (48.6%) were girls; mean (SD) age at diagnosis of type 1 diabetes was 5.1 (2.6) years. Dog exposure was identified in 102 035 children (12.1%). Follow-up started at age 1 year, and the children were followed up for as long as 10.7 years (median, 5.5 years). During follow-up, 1999 children developed type 1 diabetes. No association was found between exposure to dogs (adjusted hazard ratio [HR], 1.00; 95% CI, 0.86-1.16) and type 1 diabetes in childhood. The size of the dog (adjusted HR per 10-cm increase in height, 0.96; 95% CI, 0.86-1.06) or number of dogs in the household (1 dog: adjusted HR, 1.07; 95% CI, 0.91-1.26; 2 dogs: 0.79; 95% CI, 0.54-1.15; >= 3 dogs: 0.50; 95% CI, 0.23-1.12; compared with nonexposed children) also was not associated with type 1 diabetes risk. An analysis of children whose parent had type 1 diabetes (210 events) yielded an adjusted HR of 0.71 (95% CI, 0.43-1.17) for dog exposure. CONCLUSIONS AND RELEVANCE In a nationwide study, no evidence supporting an association of register-derived measures of dog exposure with childhood type 1 diabetes was identified.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Pediatrik hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Pediatrics hsv//eng
Pediatrik
Pediatrics

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Svennblad, BodilUppsala universitet,Uppsala kliniska forskningscentrum (UCR),Ortopedi,Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden(Swepub:uu)bosve677 (author)
Fall, Katja,1971-Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology and Biostatistics,Orebro Univ, Sch Med Sci, Clin Epidemiol & Biostat, Orebro, Sweden.(Swepub:oru)kafl (author)
Fang, FangKarolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden. (author)
Almqvist, CatarinaKarolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Lung & Allergy Unit, Stockholm, Sweden. (author)
Fall, Tove,1979-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi,Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden(Swepub:uu)tovfa878 (author)
Uppsala universitetUppsala kliniska forskningscentrum (UCR) (creator_code:org_t)

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In:JAMA pediatrics: AMER MEDICAL ASSOC171:7, s. 663-6692168-62032168-6211

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