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Elemene inhibits th...
Elemene inhibits the migration and invasion of 4T1 murine breast cancer cells via heparanase
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- Zhang, Yi (author)
- Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China.
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- Sun, Xu (author)
- Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China.
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- Nan, Nan (author)
- Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China.
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- Cao, Ke-Xin (author)
- Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China.
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- Ma, Cong (author)
- Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China.
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- Yang, Guo-Wang (author)
- Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China.
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- Yu, Ming-Wei (author)
- Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China.
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- Yang, Lin (author)
- Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China.
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- Li, Jin-Ping (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China,Biokemi och Molekylär Cellbiologi; Jin-Ping Li
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- Wang, Xiao-Min (author)
- Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China.
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- Zhang, Gan-Lin (author)
- Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China.
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Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Oncol, 23 Back Rd Art Gallery, Beijing 100010, Peoples R China Institutionen för medicinsk biokemi och mikrobiologi (creator_code:org_t)
- 2017-05-26
- 2017
- English.
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In: Molecular Medicine Reports. - : Spandidos Publications. - 1791-2997 .- 1791-3004. ; 16:1, s. 794-800
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Abstract
Subject headings
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- Elemene (ELE), a natural plant drug extracted from Curcumae Rhizoma, has been widely used for cancer treatment in China for more than 20 years. Although it is reported to be a broad-spectrum anticancer drug, the mechanism underlying the action of ELE in the treatment of breast cancer remains to be fully elucidated. Heparanase, a mammalian endo-D-glucuronidase, is involved in degradation of the extracellular matrix (ECM), and thus promotes tumor progression and metastasis. The downregulation of heparanase can effectively reduce tumor malignant behaviors. In the present study, the inhibitory effects of ELE were evaluated in breast cancer cells using a Cell Counting kit 8 assay. The migratory and invasive capabilities of cancer cells were investigated using a wound healing assay, real-time cell analysis and a Transwell assay. In addition, western blot analysis was used to assess alterations in the expression levels of key proteins. The present results confirmed the antiproliferative and antimetastatic effects of ELE, using low-molecular weight heparin (LMWH) as a positive control. In addition, ELE was demonstrated to downregulate the expression of heparanase, and decrease the phosphorylation of extracellular signal-regulated kinase and AKT. These findings suggested that ELE may be a promising agent targeting heparanase in the treatment of breast cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
Keyword
- elemene
- invasion
- migration
- heparanase
- extracellular regulated kinase
- AKT
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Zhang, Yi
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Sun, Xu
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Nan, Nan
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Cao, Ke-Xin
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Ma, Cong
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Yang, Guo-Wang
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show more...
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Yu, Ming-Wei
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Yang, Lin
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Li, Jin-Ping
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Wang, Xiao-Min
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Zhang, Gan-Lin
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
- Articles in the publication
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Molecular Medici ...
- By the university
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Uppsala University