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- Ullsten, SaraUppsala universitet,Institutionen för medicinsk cellbiologi (author)
Decreased beta-Cell Proliferation and Vascular Density in a Subpopulation of Low-Oxygenated Male Rat Islets
- Article/chapterEnglish2019
Publisher, publication year, extent ...
- 2019-06-17
- Endocrine Society,2019
- electronicrdacarrier
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- LIBRIS-ID:oai:DiVA.org:uu-330804
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-330804URI
- https://doi.org/10.1210/js.2019-00101DOI
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- Language:English
- Summary in:English
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- Title in thesis list of papers: Decreased beta cell proliferation and vascular density in a subpopulation of low-oxygenated rat islets
- Low-oxygenated and dormant islets with a capacity to become activated when neededmay play a crucial role in the complex machinery behind glucose homeostasis. We hypothesized that low-oxygenated islets, when not functionally challenged, do not rapidly cycle between activation and inactivation but are a stable population that remain low-oxygenated. As this was confirmed, we aimed to characterize these islets with regard to cell composition, vascular density, and endocrine cell proliferation. The 2-nitroimidazole low-oxygenation marker pimonidazole was administered as a single or repeated dose to Wistar Furth rats. The stability of oxygen status of islets was evaluated by immunohistochemistry as the number of islets with incorporated pimonidazole adducts after one or repeated pimonidazole injections. Adjacent sections were evaluated for islet cell composition, vascular density, and endocrine cell proliferation. Single and repeated pimonidazole injections over an 8-hour period yielded accumulation of pimonidazole adducts in the same islets. An average of 30% of all islets was in all cases positively stained for pimonidazole adducts. These islets showed a similar endocrine cell composition as other islets but had lower vascular density and beta-cell proliferation. In conclusion, low-oxygenated islets were found to be a stable subpopulation of islets for at least 8 hours. Although they have previously been observed to be less functionally active, their islet cell composition was similar to that of other islets. Consistent with their lower oxygenation, they had fewer blood vessels than other islets. Notably, beta-cell regeneration preferentially occurred in better-oxygenated islets.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
- islet vasculature
- pancreatic islets
- heterogeneity
- beta-cell proliferation
Added entries (persons, corporate bodies, meetings, titles ...)
- Lau, Joey,1979-Uppsala universitet,Institutionen för medicinsk cellbiologi(Swepub:uu)jolau226 (author)
- Carlsson, Per-OlaUppsala universitet,Institutionen för medicinsk cellbiologi,Institutionen för medicinska vetenskaper(Swepub:uu)perocarl (author)
- Uppsala universitetInstitutionen för medicinsk cellbiologi (creator_code:org_t)
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- In:Journal of the Endocrine Society: Endocrine Society3:8, s. 1608-16162472-1972
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