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SoxF factors induce...
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Chiang, Ivy Kim-NiUniv Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.
(författare)
SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
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2017-01-01
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COMPANY OF BIOLOGISTS LTD,2017
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-331237
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-331237URI
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https://doi.org/10.1242/dev.146241DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Arterial specification and differentiation are influenced by a number of regulatory pathways. While it is known that the Vegfa-Notch cascade plays a central role, the transcriptional hierarchy controlling arterial specification has not been fully delineated. To elucidate the direct transcriptional regulators of Notch receptor expression in arterial endothelial cells, we used histone signatures, DNaseI hypersensitivity and ChIP-seq data to identify enhancers for the human NOTCH1 and zebrafish notch1b genes. These enhancerswere able to direct arterial endothelial cell-restricted expression in transgenic models. Genetic disruption of SoxF binding sites established a clear requirement for members of this group of transcription factors (SOX7, SOX17 and SOX18) to drive the activity of these enhancers in vivo. Endogenous deletion of the notch1b enhancer led to a significant loss of arterial connections to the dorsal aorta in Notch pathway-deficient zebrafish. Loss of SoxF function revealed that these factors are necessary for NOTCH1 and notch1b enhancer activity and for correct endogenous transcription of these genes. These findings position SoxF transcription factors directly upstream of Notch receptor expression during the acquisition of arterial identity in vertebrates.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Fritzsche, MartinUniv Oxford, Ludwig Inst Canc Res, Nuffield Dept Clin Med, Oxford OX3 7DQ, England.
(författare)
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Pichol-Thievend, CathyUniv Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.
(författare)
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Neal, AliceUniv Oxford, Ludwig Inst Canc Res, Nuffield Dept Clin Med, Oxford OX3 7DQ, England.
(författare)
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Holmes, KellyUniv Cambridge, Li Ka Shing Ctr, Canc Res UK, Robinson Way, Cambridge CB2 0RE, England.
(författare)
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Lagendijk, AnneUniv Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.
(författare)
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Overman, JeroenUniv Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.
(författare)
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D'Angelo, DonatellaUniv Milan, Dipartimento Biosci, Via Celoria 26, I-20133 Milan, Italy.
(författare)
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Omini, AliceUniv Milan, Dipartimento Biosci, Via Celoria 26, I-20133 Milan, Italy.
(författare)
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Hermkens, DorienUniv Munster, D-48149 Munster, Germany.;Westfalische Wilhelms Univ Munster WWU, Inst Cardiovasc Organogenesis & Regenerat, Fac Med, Mendelstr 7, D-48149 Munster, Germany.;CiM Cluster Excellence, Munster, Germany.
(författare)
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Lesieur, EmmanuelleUniv Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.
(författare)
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Liu, KeUniv Liverpool, Inst Aging & Chron Dis, Liverpool L69 3GA, Merseyside, England.
(författare)
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Ratnayaka, IndrikaUniv Oxford, Ludwig Inst Canc Res, Nuffield Dept Clin Med, Oxford OX3 7DQ, England.
(författare)
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Corada, MonicaFIRC Inst Mol Oncol, IFOM, I-1620139 Milan, Italy.
(författare)
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Bou-Gharios, GeorgeUniv Liverpool, Inst Aging & Chron Dis, Liverpool L69 3GA, Merseyside, England.
(författare)
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Carroll, JasonUniv Cambridge, Li Ka Shing Ctr, Canc Res UK, Robinson Way, Cambridge CB2 0RE, England.
(författare)
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Dejana, ElisabettaUppsala universitet,Vaskulärbiologi,FIRC Inst Mol Oncol, IFOM, I-1620139 Milan, Italy(Swepub:uu)elide443
(författare)
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Schulte-Merker, StefanUniv Munster, D-48149 Munster, Germany.;Westfalische Wilhelms Univ Munster WWU, Inst Cardiovasc Organogenesis & Regenerat, Fac Med, Mendelstr 7, D-48149 Munster, Germany.;CiM Cluster Excellence, Munster, Germany.
(författare)
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Hogan, BenjaminUniv Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.
(författare)
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Beltrame, MonicaUniv Milan, Dipartimento Biosci, Via Celoria 26, I-20133 Milan, Italy.
(författare)
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De Val, SarahUniv Oxford, Ludwig Inst Canc Res, Nuffield Dept Clin Med, Oxford OX3 7DQ, England.
(författare)
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Francois, MathiasUniv Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.
(författare)
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Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.Univ Oxford, Ludwig Inst Canc Res, Nuffield Dept Clin Med, Oxford OX3 7DQ, England.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Development: COMPANY OF BIOLOGISTS LTD144:14, s. 2629-26390950-19911477-9129
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Chiang, Ivy Kim- ...
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Fritzsche, Marti ...
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Pichol-Thievend, ...
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Neal, Alice
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Holmes, Kelly
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Lagendijk, Anne
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visa fler...
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Overman, Jeroen
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D'Angelo, Donate ...
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Omini, Alice
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Hermkens, Dorien
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Lesieur, Emmanue ...
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Liu, Ke
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Ratnayaka, Indri ...
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Corada, Monica
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Bou-Gharios, Geo ...
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Carroll, Jason
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Dejana, Elisabet ...
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Schulte-Merker, ...
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Hogan, Benjamin
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Beltrame, Monica
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De Val, Sarah
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Francois, Mathia ...
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