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SoxF factors induce...
SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development
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- Chiang, Ivy Kim-Ni (author)
- Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.
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- Fritzsche, Martin (author)
- Univ Oxford, Ludwig Inst Canc Res, Nuffield Dept Clin Med, Oxford OX3 7DQ, England.
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- Pichol-Thievend, Cathy (author)
- Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.
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- Neal, Alice (author)
- Univ Oxford, Ludwig Inst Canc Res, Nuffield Dept Clin Med, Oxford OX3 7DQ, England.
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- Holmes, Kelly (author)
- Univ Cambridge, Li Ka Shing Ctr, Canc Res UK, Robinson Way, Cambridge CB2 0RE, England.
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- Lagendijk, Anne (author)
- Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.
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- Overman, Jeroen (author)
- Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.
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- D'Angelo, Donatella (author)
- Univ Milan, Dipartimento Biosci, Via Celoria 26, I-20133 Milan, Italy.
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- Omini, Alice (author)
- Univ Milan, Dipartimento Biosci, Via Celoria 26, I-20133 Milan, Italy.
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- Hermkens, Dorien (author)
- Univ Munster, D-48149 Munster, Germany.;Westfalische Wilhelms Univ Munster WWU, Inst Cardiovasc Organogenesis & Regenerat, Fac Med, Mendelstr 7, D-48149 Munster, Germany.;CiM Cluster Excellence, Munster, Germany.
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- Lesieur, Emmanuelle (author)
- Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.
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- Liu, Ke (author)
- Univ Liverpool, Inst Aging & Chron Dis, Liverpool L69 3GA, Merseyside, England.
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- Ratnayaka, Indrika (author)
- Univ Oxford, Ludwig Inst Canc Res, Nuffield Dept Clin Med, Oxford OX3 7DQ, England.
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- Corada, Monica (author)
- FIRC Inst Mol Oncol, IFOM, I-1620139 Milan, Italy.
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- Bou-Gharios, George (author)
- Univ Liverpool, Inst Aging & Chron Dis, Liverpool L69 3GA, Merseyside, England.
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- Carroll, Jason (author)
- Univ Cambridge, Li Ka Shing Ctr, Canc Res UK, Robinson Way, Cambridge CB2 0RE, England.
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- Dejana, Elisabetta (author)
- Uppsala universitet,Vaskulärbiologi,FIRC Inst Mol Oncol, IFOM, I-1620139 Milan, Italy
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- Schulte-Merker, Stefan (author)
- Univ Munster, D-48149 Munster, Germany.;Westfalische Wilhelms Univ Munster WWU, Inst Cardiovasc Organogenesis & Regenerat, Fac Med, Mendelstr 7, D-48149 Munster, Germany.;CiM Cluster Excellence, Munster, Germany.
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- Hogan, Benjamin (author)
- Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.
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- Beltrame, Monica (author)
- Univ Milan, Dipartimento Biosci, Via Celoria 26, I-20133 Milan, Italy.
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- De Val, Sarah (author)
- Univ Oxford, Ludwig Inst Canc Res, Nuffield Dept Clin Med, Oxford OX3 7DQ, England.
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- Francois, Mathias (author)
- Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia.
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Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia Univ Oxford, Ludwig Inst Canc Res, Nuffield Dept Clin Med, Oxford OX3 7DQ, England. (creator_code:org_t)
- 2017-01-01
- 2017
- English.
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In: Development. - : COMPANY OF BIOLOGISTS LTD. - 0950-1991 .- 1477-9129. ; 144:14, s. 2629-2639
- Related links:
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https://dev.biologis...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Arterial specification and differentiation are influenced by a number of regulatory pathways. While it is known that the Vegfa-Notch cascade plays a central role, the transcriptional hierarchy controlling arterial specification has not been fully delineated. To elucidate the direct transcriptional regulators of Notch receptor expression in arterial endothelial cells, we used histone signatures, DNaseI hypersensitivity and ChIP-seq data to identify enhancers for the human NOTCH1 and zebrafish notch1b genes. These enhancerswere able to direct arterial endothelial cell-restricted expression in transgenic models. Genetic disruption of SoxF binding sites established a clear requirement for members of this group of transcription factors (SOX7, SOX17 and SOX18) to drive the activity of these enhancers in vivo. Endogenous deletion of the notch1b enhancer led to a significant loss of arterial connections to the dorsal aorta in Notch pathway-deficient zebrafish. Loss of SoxF function revealed that these factors are necessary for NOTCH1 and notch1b enhancer activity and for correct endogenous transcription of these genes. These findings position SoxF transcription factors directly upstream of Notch receptor expression during the acquisition of arterial identity in vertebrates.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- Notch1
- SoxF
- Artery
- Arterial enhancer
- Endothelial cell
- Transcriptional regulation
- Zebrafish
- Human
- Mouse
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Chiang, Ivy Kim- ...
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Fritzsche, Marti ...
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Pichol-Thievend, ...
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Neal, Alice
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Holmes, Kelly
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Lagendijk, Anne
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show more...
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Overman, Jeroen
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D'Angelo, Donate ...
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Omini, Alice
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Hermkens, Dorien
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Lesieur, Emmanue ...
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Liu, Ke
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Ratnayaka, Indri ...
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Corada, Monica
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Bou-Gharios, Geo ...
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Carroll, Jason
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Dejana, Elisabet ...
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Schulte-Merker, ...
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Hogan, Benjamin
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Beltrame, Monica
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De Val, Sarah
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Francois, Mathia ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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Uppsala University