On the use of ion-crosslinked nanocellulose hydrogels for wound healing solutions: Physicochemical properties and application-oriented biocompatibility studies

Basu, AlexUppsala universitet,Nanoteknologi och funktionella material,Nanotechnology and Functional Materials,Uppsala University, Sweden (författare)

On the use of ion-crosslinked nanocellulose hydrogels for wound healing solutions : Physicochemical properties and application-oriented biocompatibility studies

Calcium ion-crosslinked nanofibrillated cellulose (NFC) hydrogels were investigated as potential materials for wound healing dressings. The physicochemical properties of the hydrogels were examined by rheology and water retention tests. Skin cells and monocytes were selected for application-oriented bio-compatibility studies. The NFC hydrogels presented entangled fibrous networks and solid-like behavior. Water retention tests showed the material's potential to maintain a suitable moist environment for different type of wounds. The hydrogels did not affect dermal fibroblasts monolayer cultures upon directcontact, as cell monolayers remained intact after application, incubation and removal of the materials. Inflammatory response studies with blood-derived mononuclear cells revealed the inert nature of the hydrogels in terms of cytokine secretion and reactive oxygen species production. Results highlight the great potential of ion-crosslinked NFC hydrogels for the development of advanced wound dressings, where further functionalization of the material could lead to improved properties towards the healing of specific wound types.

TEKNIK OCH TEKNOLOGIER Nanoteknik hsv//swe
ENGINEERING AND TECHNOLOGY Nano-technology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Medicinsk bioteknologi hsv//swe
MEDICAL AND HEALTH SCIENCES Medical Biotechnology hsv//eng
Nanofibrillated cellulose
Inflammation
Fibroblasts
Mononuclear cells
Engineering Science with specialization in Nanotechnology and Functional Materials
Teknisk fysik med inriktning mot nanoteknologi och funktionella material

Lindh, Jonas,1977-Uppsala universitet,Nanoteknologi och funktionella material,Nanotechnology and Functional Materials,Uppsala university, Sweden(Swepub:uu)jolin193 (författare)
Ålander, EvaRISE,Bioekonomi,Rise Bioeconomy (författare)
Strömme, Maria,1970-Uppsala universitet,Nanoteknologi och funktionella material,Nanotechnology and Functional Materials,Uppsala university, Sweden(Swepub:uu)mst26208 (författare)
Ferraz, Natalia,1976-Uppsala universitet,Nanoteknologi och funktionella material,Nanotechnology and Functional Materials,Uppsala university, Sweden(Swepub:uu)natfe727 (författare)
Uppsala universitetNanoteknologi och funktionella material (creator_code:org_t)

Av författaren/redakt...: Basu, Alex; Lindh, Jonas, 19 ...; Ålander, Eva; Strömme, Maria, ...; Ferraz, Natalia, ...

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