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N-terminal pro B-ty...
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Svennberg, EmmaKarolinska Institutet
(författare)
N-terminal pro B-type natriuretic peptide in systematic screening for atrial fibrillation
- Artikel/kapitelEngelska2017
Förlag, utgivningsår, omfång ...
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2017-03-02
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BMJ,2017
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-332926
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-332926URI
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https://doi.org/10.1136/heartjnl-2016-310236DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:136298034URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Objective Screening for atrial fibrillation (AF) in individuals aged 65 and above is recommended by the European Society of Cardiology. Increased levels of the biomarker N-terminal pro B-type natriuretic peptide (NT-proBNP) has in cohort studies been associated with incident AF. The aim of this study was to assess whether NT-proBNP could be useful for AF detection in systematic screening.Methods The Strokestop study entailed 7173 Swedish residents aged 75/76 that were screened for AF using twice daily intermittent ECG recordings during 2 weeks. In a substudy of 886 participants, the last 815 consecutive participants and 71 individuals with newly detected AF, levels of NT-proBNP were determined.Results Participants with newly detected AF (n=96) had a median NT-proBNP of 330 ng/L (IQR 121; 634). In individuals without AF (n=742), median NT-proBNP was 171 ng/L (IQR 95; 283), p<0.001. The CHA2DS2-VASc parameters did not differ significantly between individuals with newly detected AF and without AF nor between newly detected AF in the NT-proBNP cohort compared with the cohort where NT-proBNP was not assessed. Using an NT-proBNP cut-off of >= 125 ng/L in a non-acute setting yielded a negative predictive value of 92%, meaning that 35% fewer participants would need to be screened when applied to systematic AF screening. Adding weight to NT-proBNP further reduced participants needed to be screened with a preserved sensitivity.Conclusions NT-proBNP was increased in individuals with newly detected AF. Prospective studies could clarify if NT-proBNP can be used to correctly select individuals that benefit most from AF screening.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Henriksson, PeterKarolinska Institutet
(författare)
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Engdahl, JohanKarolinska Institutet
(författare)
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Hijazi, ZiadUppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi(Swepub:uu)ziahi940
(författare)
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Al-Khalili, FarisKarolinska Institutet
(författare)
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Friberg, LeifKarolinska Institutet
(författare)
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Frykman, VivekaKarolinska Institutet
(författare)
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Karolinska InstitutetUppsala kliniska forskningscentrum (UCR)
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Heart: BMJ103:16, s. 1271-12771355-60371468-201X
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Heart
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