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Improvement of myoc...
Improvement of myocardial infarction risk prediction via inflammation-associated metabolite biomarkers
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- Ward-Caviness, Cavin K. (author)
- Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.
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- Xu, Tao (author)
- Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.;Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany.
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- Aspelund, Thor (author)
- Iceland Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Ctr Publ Hlth, Reykjavik, Iceland.
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- Thorand, Barbara (author)
- Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.
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- Montrone, Corinna (author)
- Helmholtz Zentrum Munchen, Inst Bioinformat & Syst Biol, Neuherberg, Germany.
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- Meisinger, Christa (author)
- Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.
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- Dunger-Kaltenbach, Irmtraud (author)
- Helmholtz Zentrum Munchen, Inst Bioinformat & Syst Biol, Neuherberg, Germany.
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- Zierer, Astrid (author)
- Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.
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- Yu, Zhonghao (author)
- Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.;Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany.
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- Helgadottir, Inga R. (author)
- Iceland Heart Assoc, Kopavogur, Iceland.
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- Harris, Tamara B. (author)
- NIA, Bethesda, MD 20892 USA.
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- Launer, Lenore J. (author)
- NIA, Bethesda, MD 20892 USA.
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- Ganna, Andrea (author)
- Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
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- Eiriksdottir, Gudny (author)
- Iceland Heart Assoc, Kopavogur, Iceland.
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- Waldenberger, Melanie (author)
- Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.;Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany.
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- Prehn, Cornelia (author)
- Helmholtz Zentrum Munchen, Inst Expt Genet, Genome Anal Ctr, Neuherberg, Germany.
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- Suhre, Karsten (author)
- Helmholtz Zentrum Munchen, Inst Bioinformat & Syst Biol, Neuherberg, Germany.
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- Illig, Thomas (author)
- Hannover Med Sch, Hannover Unified Biobank, Hannover, Germany.
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- Adamski, Jerzy (author)
- Helmholtz Zentrum Munchen, Inst Expt Genet, Genome Anal Ctr, Neuherberg, Germany.;Tech Univ Munich, Chair Expt Genet, Munich, Germany.
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- Ruepp, Andreas (author)
- Helmholtz Zentrum Munchen, Inst Bioinformat & Syst Biol, Neuherberg, Germany.;Tech Univ Munich, Chair Expt Genet, Munich, Germany.
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- Koenig, Wolfgang (author)
- Univ Ulm, Med Ctr, Dept Internal Med 2, Ulm, Germany.;Tech Univ Munich, Deutsches Herzzentrum, Munich, Germany.;DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany.
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- Gudnason, Vilmundur (author)
- Iceland Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.
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- Emilsson, Valur (author)
- Iceland Heart Assoc, Kopavogur, Iceland.;Univ Iceland, Fac Pharmaceut Sci, Reykjavik, Iceland.
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- Wang-Sattler, Rui (author)
- Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.;Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany.
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- Peters, Annette (author)
- Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.;DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany.;Harvard Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA.
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Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany Helmholtz Zentrum Munchen, Inst Epidemiol 2, Neuherberg, Germany.;Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany. (creator_code:org_t)
- 2017-03-02
- 2017
- English.
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In: Heart. - : BMJ. - 1355-6037 .- 1468-201X. ; 103:16, s. 1278-1285
- Related links:
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Abstract
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- Objective The comprehensive assaying of low-molecular-weight compounds, for example, metabolomics, provides a unique tool to uncover novel biomarkers and understand pathways underlying myocardial infarction (MI). We used a targeted metabolomics approach to identify biomarkers for MI and evaluate their involvement in the pathogenesis of MI.Methods and results Using three independent, prospective cohorts (KORA S4, KORA S2 and AGES-REFINE), totalling 2257 participants without a history of MI at baseline, we identified metabolites associated with incident MI (266 cases). We also investigated the association between the metabolites and high-sensitivity C reactive protein (hsCRP) to understand the relation between these metabolites and systemic inflammation. Out of 140 metabolites, 16 were nominally associated (p<0.05) with incident MI in KORA S4. Three metabolites, arginine and two lysophosphatidylcholines (LPC 17: 0 and LPC 18:2), were selected as biomarkers via a backward stepwise selection procedure in the KORA S4 and were significant (p<0.0003) in a meta-analysis comprising all three studies including KORA S2 and AGES-REFINE. Furthermore, these three metabolites increased the predictive value of the Framingham risk score, increasing the area under the receiver operating characteristic score in KORA S4 (from 0.70 to 0.78, p=0.001) and AGES-REFINE study (from 0.70 to 0.76, p=0.02), but was not observed in KORA S2. The metabolite biomarkers attenuated the association between hsCRP and MI, indicating a potential link to systemic inflammatory processes.Conclusions We identified three metabolite biomarkers, which in combination increase the predictive value of the Framingham risk score. The attenuation of the hsCRP-MI association by these three metabolites indicates a potential link to systemic inflammation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Heart
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- By the author/editor
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Ward-Caviness, C ...
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Xu, Tao
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Aspelund, Thor
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Thorand, Barbara
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Montrone, Corinn ...
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Meisinger, Chris ...
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Dunger-Kaltenbac ...
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Zierer, Astrid
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Yu, Zhonghao
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Helgadottir, Ing ...
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Harris, Tamara B ...
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Launer, Lenore J ...
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Ganna, Andrea
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Lind, Lars
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Eiriksdottir, Gu ...
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Waldenberger, Me ...
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Prehn, Cornelia
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Suhre, Karsten
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Illig, Thomas
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Adamski, Jerzy
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Ruepp, Andreas
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Koenig, Wolfgang
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Gudnason, Vilmun ...
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Emilsson, Valur
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Wang-Sattler, Ru ...
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Peters, Annette
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Heart
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Uppsala University