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  • Poelzl, GerhardUniv Klin Innsbruck, Innsbruck, Austria. (author)

Repetitive use of levosimendan in advanced heart failure : need for stronger evidence in a field in dire need of a useful therapy

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • Elsevier BV,2017
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-333061
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-333061URI
  • https://doi.org/10.1016/j.ijcard.2017.05.081DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:136264525URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Patients in the latest stages of heart failure are severely compromised, with poor quality of life and frequent hospitalizations. Heart transplantation and left ventricular assist device implantation are viable options only for a minority, and intermittent or continuous infusions of positive inotropes may be needed as a bridge therapy or as a symptomatic approach. In these settings, levosimendan has potential advantages over conventional inotropes (catecholamines and phosphodiesterase inhibitors), such as sustained effects after initial infusion, synergy with beta-blockers, and no increase in oxygen consumption. Levosimendan has been suggested as a treatment that reduces re-hospitalization and improves quality of life. However, previous clinical studies of intermittent infusions of levosimendan were not powered to show statistical significance on key outcome parameters. A panel of 45 expert clinicians from 12 European countries met in Rome on November 24-25, 2016 to review the literature and envision an appropriately designed clinical trial addressing these needs. In the earlier FIGHT trial (daily subcutaneous injection of liraglutide in heart failure patients with reduced ejection fraction) a composite Global Rank Score was used as primary end-point where death, re-hospitalization, and change in N-terminalprohormone-brain natriuretic peptide level were considered in a hierarchical order. In the present study, we tested the same end-point post hoc in the PERSIST and LEVOREP trials on oral and repeated i.v. levosimendan, respectively, and demonstrated superiority of levosimendan treatment vs placebo. The use of the same composite end-point in a properly powered study on repetitive levosimendan in advanced heart failure is strongly advocated.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Altenberger, JohannRehabil Zentrum Grossgmain, Salzburg, Austria. (author)
  • Baholli, LoantKlinikum Dortmund Mitte, Dortmund, Germany. (author)
  • Beltran, PaolaHM Broggi, Barcelona, Spain. (author)
  • Borbely, AttilaUniv Debrecen, Fac Med, Div Clin Physiol, Debrecen, Hungary. (author)
  • Comin-Colet, JosepUniv Hosp Bellvitge, Barcelona, Spain. (author)
  • Delgado, Juan F.Hosp 12 Octubre, Madrid, Spain. (author)
  • Fedele, FrancescoSapienza Univ, Policlin Umberto 1, Rome, Italy. (author)
  • Fontana, AntonellaOrion Pharma Srl, Milan, Italy. (author)
  • Fruhwald, FriedrichMed Univ Klin, Graz, Austria. (author)
  • Giamouzis, GregoryUniv Thessaly, Larissa Univ Hosp, Larisa, Greece. (author)
  • Giannakoulas, GeorgeAristotle Univ Thessaloniki, Thessaloniki, Greece. (author)
  • Garcia-Gonzalez, Martin J.H La Laguna, Tenerife, Spain. (author)
  • Gustafsson, FinnRigshosp, Copenhagen, Denmark. (author)
  • Kaikkonen, KariOulu Univ Hosp, Oulu, Finland. (author)
  • Kivikko, MattiOrion Pharma, Espoo, Finland. (author)
  • Kubica, JacekNicolaus Copernicus Univ, Coll Med, Bydgoszcz, Poland. (author)
  • von Lewinski, DirkMed Univ Klin, Graz, Austria. (author)
  • Lofman, IdaKarolinska Institutet (author)
  • Malfatto, GabriellaIst Auxol Italiano, Milan, Italy. (author)
  • Manito, NicolasUniv Hosp Bellvitge, Barcelona, Spain. (author)
  • Martinez-Selles, MartinH Gregorio Maranon, Madrid, Spain. (author)
  • Masip, JosepHM Broggi, Barcelona, Spain. (author)
  • Merkely, BelaSemmelweis Univ, Heart & Vasc Ctr, Budapest, Hungary. (author)
  • Morandi, FabrizioCircolo Hosp & Macchi Fdn, Varese, Italy. (author)
  • Molgaard, HenningAarhus Univ Hosp, Skejby, Denmark. (author)
  • Oliva, FabrizioOsped Niguarda Ca Granda, Milan, Italy. (author)
  • Pantev, EmilHelsingborgs Iasarett, Helsingborg, Sweden. (author)
  • Papp, ZoltanUniv Debrecen, Fac Med, Div Clin Physiol, Debrecen, Hungary. (author)
  • Perna, Gian PieroOsped Riuniti, Dipartimento Sci Cardiol Med Chirurg, Ancona, Italy. (author)
  • Pfister, RomanUniv Cologne, Herzzentrum, Klin Innere Med 3, Cologne, Germany. (author)
  • Piazza, VitoAzienda Osped San Camillo Forlanini, Rome, Italy. (author)
  • Bover, RamonH Clin San Carlos, Madrid, Spain. (author)
  • Rangel-Sousa, DiegoH Virgen Rocio, Seville, Spain. (author)
  • Recio-Mayoral, AlejandroHosp Univ Virgen Macarena, Seville, Spain. (author)
  • Reinecke, AlexanderUni Klinikum Schleswig Holstein, Kiel, Germany. (author)
  • Rieth, AndreasKerckhoff Klin, Bad Nauheim, Germany. (author)
  • Sarapohja, ToniOrion Pharma, Espoo, Finland. (author)
  • Schmidt, GunterCHARITE Univ Med Berlin, Berlin, Germany. (author)
  • Seidel, MirkoUnfallkrankenhaus Berlin, Innere Med Klin, Berlin, Germany. (author)
  • Stoerk, StefanUniv Wurzburg, Comprehens Heart Failure Ctr, Wurzburg, Germany.;Univ Hosp, Wurzburg, Germany. (author)
  • Vrtovec, BojanUniv Clin Ctr, Ljubljana, Slovenia. (author)
  • Wikström, GerhardUppsala universitet,Kardiologi(Swepub:uu)gewik021 (author)
  • Yerly, PatrikCHU Vaudois, Lausanne, Switzerland. (author)
  • Pollesello, PieroOrion Pharma, Espoo, Finland. (author)
  • Univ Klin Innsbruck, Innsbruck, Austria.Rehabil Zentrum Grossgmain, Salzburg, Austria. (creator_code:org_t)

Related titles

  • In:International Journal of Cardiology: Elsevier BV243, s. 389-3950167-52731874-1754

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