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Inflammatory marker...
Inflammatory markers and extent and progression of early atherosclerosis : Meta-analysis of individual-participant-data from 20 prospective studies of the PROG-IMT collaboration
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- Willeit, Peter (författare)
- Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge CB2 1TN, England.;Med Univ Innsbruck, Dept Neurol, A-6020 Innsbruck, Austria.
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- Thompson, Simon G. (författare)
- Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge CB2 1TN, England.
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- Agewall, Stefan (författare)
- Karolinska Institutet
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visa fler...
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- Bergström, Göran, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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- Bickel, Horst (författare)
- Tech Univ Munich, Univ Hosp, Dept Psychiat & Psychotherapy, D-80290 Munich, Germany.
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- Catapano, Alberico L. (författare)
- Univ Milan, Dept Pharmacol Sci, Milan, Italy.;IRCSS Multimed Sesto S Giovanni, Milan, Italy.
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- Chien, Kuo-Liong (författare)
- Natl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med, Taipei 10764, Taiwan.;Natl Taiwan Univ, Dept Internal Med, Taipei 10764, Taiwan.
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- de Groot, Eric (författare)
- Acad Med Ctr, Cardiol & Thorac Surg & Imagelabonline & Cardiova, Amsterdam, Netherlands.
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- Empana, Jean-Philippe (författare)
- Univ Paris 05, INSERM, U970, Paris, France.
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- Etgen, Thorleif (författare)
- Klinikum Traunstein, Kliniken Sudostbayern, Dept Neurol, Traunstein, Germany.
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- Franco, Oscar H. (författare)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
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- Iglseder, Bernhard (författare)
- Paracelsus Med Univ, Dept Geriatr Med, Salzburg, Austria.;Gemeinnutzige Salzburger Landeskliniken Betriebsg, Christian Doppler Klin, Salzburg, Austria.
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- Johnsen, Stein H. (författare)
- Univ Hosp Northern Norway, Dept Neurol & Neurophysiol, Tromso, Norway.;Univ Tromso, Dept Clin Med, Tromso, Norway.
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- Kavousi, Maryam (författare)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
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- Lind, Lars (författare)
- Uppsala universitet,Kardiovaskulär epidemiologi
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- Liu, Jing (författare)
- Beijing Inst Heart Lung & Blood Vessel Dis, Dept Epidemiol, Beijing, Peoples R China.
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- Mathiesen, Ellisiv B. (författare)
- Univ Hosp Northern Norway, Dept Neurol & Neurophysiol, Tromso, Norway.;Univ Tromso, Dept Clin Med, Tromso, Norway.
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- Norata, Giuseppe D. (författare)
- Univ Milan, Dept Pharmacol Sci, Cinisello Balsamo, Italy.;Bassini Hosp, SISA Ctr Study Atherosclerosis, Cinisello Balsamo, Italy.
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- Olsen, Michael H. (författare)
- Odense Univ Hosp, Ctr Individualized Med Arterial Dis, Dept Endocrinol, Odense, Denmark.
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- Papagianni, Aikaterini (författare)
- Aristotle Univ Thessaloniki, Hippokrat Gen Hosp, Dept Nephrol, Thessaloniki, Greece.
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- Poppert, Holger (författare)
- Tech Univ Munich, Univ Hosp, Dept Neurol, D-80290 Munich, Germany.
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- Price, Jackie F. (författare)
- Univ Edinburgh, Ctr Populat Hlth Sci, Edinburgh EH8 9YL, Midlothian, Scotland.
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- Sacco, Ralph L. (författare)
- Univ Miami, Miller Sch Med, Dept Neurol, Coral Gables, FL 33124 USA.
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- Yanez, David N. (författare)
- Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
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- Zhao, Dong (författare)
- Beijing Inst Heart Lung & Blood Vessel Dis, Dept Epidemiol, Beijing, Peoples R China.
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- Schminke, Ulf (författare)
- Greifswald Univ Clin, Dept Neurol, Greifswald, Germany.
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- Buelbuel, Alpaslan (författare)
- Univ Hosp Frankfurt, Dept Neurol, Frankfurt, Germany.
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- Polak, Joseph F. (författare)
- Tufts Univ, Sch Med, Tufts Med Ctr, Boston, MA 02111 USA.
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- Sitzer, Matthias (författare)
- Univ Hosp Frankfurt, Dept Neurol, Frankfurt, Germany.;Klinikum Herford, Dept Neurol, Herford, Germany.
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- Hofman, Albert (författare)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
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- Grigore, Liliana (författare)
- Univ Milan, Dept Pharmacol Sci, Cinisello Balsamo, Italy.;Bassini Hosp, SISA Ctr Study Atherosclerosis, Cinisello Balsamo, Italy.
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- Doerr, Marcus (författare)
- Univ Med Greifswald, Dept Internal Med B, Greifswald, Germany.;German Ctr Cardiovasc Res DZHK, Halle, Germany.
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- Su, Ta-Chen (författare)
- Natl Taiwan Univ, Dept Internal Med, Taipei 10764, Taiwan.
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- Ducimetiere, Pierre (författare)
- Univ Paris 11, Le Kremlin Bicetre, France.
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- Xie, Wuxiang (författare)
- Beijing Inst Heart Lung & Blood Vessel Dis, Dept Epidemiol, Beijing, Peoples R China.
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- Ronkainen, Kimmo (författare)
- Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
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- Kiechl, Stefan (författare)
- Med Univ Innsbruck, Dept Neurol, A-6020 Innsbruck, Austria.
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- Rundek, Tatjana (författare)
- Univ Miami, Miller Sch Med, Dept Neurol, Coral Gables, FL 33124 USA.
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- Robertson, Christine (författare)
- Univ Edinburgh, Ctr Populat Hlth Sci, Edinburgh EH8 9YL, Midlothian, Scotland.
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- Fagerberg, Björn, 1943 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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- Bokemark, Lena, 1960 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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- Steinmetz, Helmuth (författare)
- Univ Hosp Frankfurt, Dept Neurol, Frankfurt, Germany.
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- Ikram, M. Arfan (författare)
- Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
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- Voelzke, Henry (författare)
- Inst Community Med, SHIP Clin Epidemiol Res, Greifswald, Germany.
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- Lin, Hung-Ju (författare)
- Natl Taiwan Univ, Dept Internal Med, Taipei 10764, Taiwan.;Natl Taiwan Univ Hosp, Hlth Management Ctr, Taipei, Taiwan.
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- Plichart, Matthieu (författare)
- Univ Paris 05, INSERM, U970, Paris, France.;Broca Hosp, Gerontol Dept, Paris, France.
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- Tuomainen, Tomi-Pekka (författare)
- Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
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- Desvarieux, Moise (författare)
- Columbia Univ, Mailman Sch Publ Hlth, Dept Epidemiol, New York, NY USA.;Ecole Hautes Etudes Sante Publ, Paris, France.;INSERM, U738, Paris, France.
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- McLachlan, Stela (författare)
- Univ Edinburgh, Ctr Populat Hlth Sci, Edinburgh EH8 9YL, Midlothian, Scotland.
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- Schmidt, Caroline, 1966 (författare)
- Gothenburg University,Göteborgs universitet,Wallenberglaboratoriet,Wallenberg Laboratory
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- Kauhanen, Jussi (författare)
- Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio, Finland.
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- Willeit, Johann (författare)
- Med Univ Innsbruck, Dept Neurol, A-6020 Innsbruck, Austria.
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- Lorenz, Matthias W. (författare)
- Univ Hosp Frankfurt, Dept Neurol, Frankfurt, Germany.
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- Sander, Dirk (författare)
- Benedictus Krankenhaus Tutzing & Feldafing, Dept Neurol, Tutzing, Germany.;Tech Univ Munich, D-80290 Munich, Germany.
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Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge CB2 1TN, England;Med Univ Innsbruck, Dept Neurol, A-6020 Innsbruck, Austria. Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge CB2 1TN, England. (creator_code:org_t)
- 2014-11-21
- 2016
- Engelska.
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Ingår i: European Journal of Preventive Cardiology. - : Oxford University Press (OUP). - 2047-4873 .- 2047-4881. ; 23:2, s. 194-205
- Relaterad länk:
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- BackgroundLarge-scale epidemiological evidence on the role of inflammation in early atherosclerosis, assessed by carotid ultrasound, is lacking. We aimed to quantify cross-sectional and longitudinal associations of inflammatory markers with common-carotid-artery intima-media thickness (CCA-IMT) in the general population. MethodsInformation on high-sensitivity C-reactive protein, fibrinogen, leucocyte count and CCA-IMT was available in 20 prospective cohort studies of the PROG-IMT collaboration involving 49,097 participants free of pre-existing cardiovascular disease. Estimates of associations were calculated within each study and then combined using random-effects meta-analyses. ResultsMean baseline CCA-IMT amounted to 0.74mm (SD=0.18) and mean CCA-IMT progression over a mean of 3.9 years to 0.011mm/year (SD=0.039). Cross-sectional analyses showed positive linear associations between inflammatory markers and baseline CCA-IMT. After adjustment for traditional cardiovascular risk factors, mean differences in baseline CCA-IMT per one-SD higher inflammatory marker were: 0.0082mm for high-sensitivity C-reactive protein (p<0.001); 0.0072mm for fibrinogen (p<0.001); and 0.0025mm for leucocyte count (p=0.033). Inflammatory load', defined as the number of elevated inflammatory markers (i.e. in upper two quintiles), showed a positive linear association with baseline CCA-IMT (p<0.001). Longitudinal associations of baseline inflammatory markers and changes therein with CCA-IMT progression were null or at most weak. Participants with the highest inflammatory load' had a greater CCA-IMT progression (p=0.015). ConclusionInflammation was independently associated with CCA-IMT cross-sectionally. The lack of clear associations with CCA-IMT progression may be explained by imprecision in its assessment within a limited time period. Our findings for inflammatory load' suggest important combined effects of the three inflammatory markers on early atherosclerosis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Inflammation
- atherosclerosis
- meta-analysis
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- ref (ämneskategori)
- art (ämneskategori)
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Willeit, Peter
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Thompson, Simon ...
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Agewall, Stefan
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Bergström, Göran ...
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Bickel, Horst
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Catapano, Alberi ...
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visa fler...
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Chien, Kuo-Liong
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de Groot, Eric
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Empana, Jean-Phi ...
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Etgen, Thorleif
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Franco, Oscar H.
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Iglseder, Bernha ...
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Johnsen, Stein H ...
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Kavousi, Maryam
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Lind, Lars
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Liu, Jing
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Mathiesen, Ellis ...
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Norata, Giuseppe ...
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Olsen, Michael H ...
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Papagianni, Aika ...
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Poppert, Holger
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Price, Jackie F.
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Sacco, Ralph L.
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Yanez, David N.
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Zhao, Dong
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Schminke, Ulf
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Buelbuel, Alpasl ...
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Polak, Joseph F.
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Sitzer, Matthias
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Hofman, Albert
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Grigore, Liliana
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Doerr, Marcus
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Su, Ta-Chen
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Ducimetiere, Pie ...
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Xie, Wuxiang
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Ronkainen, Kimmo
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Kiechl, Stefan
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Rundek, Tatjana
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Robertson, Chris ...
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Fagerberg, Björn ...
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Bokemark, Lena, ...
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Steinmetz, Helmu ...
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Ikram, M. Arfan
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Voelzke, Henry
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Lin, Hung-Ju
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Plichart, Matthi ...
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Tuomainen, Tomi- ...
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Desvarieux, Mois ...
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McLachlan, Stela
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Schmidt, Carolin ...
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Kauhanen, Jussi
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Willeit, Johann
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Lorenz, Matthias ...
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Sander, Dirk
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