Ion-crosslinked wood-derived nanocellulose hydrogels with tunable antibacterial properties: Candidate materials for advanced wound care applications

Basu, AlexUppsala universitet,Nanoteknologi och funktionella material,Nanotechnology and Functional Materials (författare)

Ion-crosslinked wood-derived nanocellulose hydrogels with tunable antibacterial properties : Candidate materials for advanced wound care applications

Development of advanced dressings with antimicrobial properties for the treatment of infected wounds is an important approach in the fight against evolution of antibiotic resistant bacterial strains. Herein, the effects of ion-crosslinked nanocellulose hydrogels on bacteria commonly found in infected wounds were investigated in vitro. By using divalent calcium or copper ions as crosslinking agents, different antibacterial properties against the bacterial strains Staphylococcus epidermidis and Pseudomonas aeruginosa were obtained. Calcium crosslinked hydrogels were found to retard S. epidermidis growth (up to 266% increase in lag time, 36% increase in doubling time) and inhibited P. aeruginosa biofilm formation, while copper crosslinked hydrogels prevented S. epidermidis growth and were bacteriostatic towards P. aeruginosa (49% increase in lag time, 78% increase in doubling time). The wound dressing candidates furthermore displayed barrier properties towards both S. epidermidis and P. aeruginosa, hence making them interesting for further development of advanced wound dressings with tunable antibacterial properties.

TEKNIK OCH TEKNOLOGIER Nanoteknik hsv//swe
ENGINEERING AND TECHNOLOGY Nano-technology hsv//eng
Nanofibrillated cellulose
Biofilm
Wound dressing
Infected wound
Teknisk fysik med inriktning mot nanoteknologi och funktionella material
Engineering Science with specialization in Nanotechnology and Functional Materials

Heitz, KarenUppsala universitet,Nanoteknologi och funktionella material,Nanotechnology and Functional Materials(Swepub:uu)karhe494 (författare)
Strömme, Maria,1970-Uppsala universitet,Nanoteknologi och funktionella material,Nanotechnology and Functional Materials(Swepub:uu)mst26208 (författare)
Welch, Ken,1968-Uppsala universitet,Nanoteknologi och funktionella material,Nanotechnology and Functional Materials(Swepub:uu)kewel087 (författare)
Ferraz, Natalia,1976-Uppsala universitet,Nanoteknologi och funktionella material,Nanotechnology and Functional Materials(Swepub:uu)natfe727 (författare)
Uppsala universitetNanoteknologi och funktionella material (creator_code:org_t)

Av författaren/redakt...: Basu, Alex; Heitz, Karen; Strömme, Maria, ...; Welch, Ken, 1968 ...; Ferraz, Natalia, ...

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