Sökning: WFRF:(Stavropoulos Giokas Catherine) >
Cytotoxic T cells i...
Cytotoxic T cells in chronic idiopathic neutropenia express restricted antigen receptors
-
- Mastrodemou, Semeli (författare)
- Univ Crete, Sch Med, Dept Hematol, Iraklion, Greece.
-
- Stalika, Evangelia (författare)
- Ctr Res & Technol, Inst Appl Biosci, Thessaloniki, Greece.
-
- Vardi, Anna (författare)
- Ctr Res & Technol, Inst Appl Biosci, Thessaloniki, Greece.
-
visa fler...
-
- Gemenetzi, Katerina (författare)
- Ctr Res & Technol, Inst Appl Biosci, Thessaloniki, Greece.
-
- Spanoudakis, Michalis (författare)
- Univ Crete, Sch Med, Dept Hematol, Iraklion, Greece.
-
- Karypidou, Maria (författare)
- Ctr Res & Technol, Inst Appl Biosci, Thessaloniki, Greece.
-
- Mavroudi, Irene (författare)
- Univ Crete, Sch Med, Dept Hematol, Iraklion, Greece.
-
- Hadzidimitriou, Anastasia (författare)
- Ctr Res & Technol, Inst Appl Biosci, Thessaloniki, Greece.
-
- Stavropoulos-Giokas, Catherine (författare)
- Acad Athens, Fdn Biomed Res, Hellen Cord Blood Bank, Athens, Greece.
-
- Papadaki, Helen A. (författare)
- Univ Crete, Sch Med, Dept Hematol, Iraklion, Greece.
-
- Stamatopoulos, Kostas (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab,Ctr Res & Technol, Inst Appl Biosci, Thessaloniki, Greece
-
visa färre...
-
Univ Crete, Sch Med, Dept Hematol, Iraklion, Greece Ctr Res & Technol, Inst Appl Biosci, Thessaloniki, Greece. (creator_code:org_t)
- 2017-05-23
- 2017
- Engelska.
-
Ingår i: Leukemia and Lymphoma. - : TAYLOR & FRANCIS LTD. - 1042-8194 .- 1029-2403. ; 58:12, s. 2926-2933
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Chronic idiopathic neutropenia (CIN) is an acquired disorder of granulopoiesis characterized by female predominance and mostly uncomplicated course. Crucial to CIN pathophysiology is the presence of activated T lymphocytes with myelosuppressive properties in both peripheral blood (PB) and bone marrow (BM). We systematically profiled the T cell receptor beta chain (TRB) gene repertoire in CD8(+) cells of 34 CIN patients through subcloning/Sanger sequencing analysis of TRBV-TRBD-TRBJ gene rearrangements. Remarkable repertoire skewing and oligoclonality were observed, along with shared clonotypes between different patients, alluding to antigen selection. Cross-comparison of our sequence dataset with public TRB sequence databases revealed that CIN may rarely share common immunogenetic features with other entities, however, the CIN TRB repertoire is largely disease-biased. Overall, these findings suggest that CIN may be driven by long-term exposure to a restricted set of specific CIN-associated antigens.
Nyckelord
- Chronic idiopathic neutropenia
- T cell receptor
- antigen selection
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Mastrodemou, Sem ...
-
Stalika, Evangel ...
-
Vardi, Anna
-
Gemenetzi, Kater ...
-
Spanoudakis, Mic ...
-
Karypidou, Maria
-
visa fler...
-
Mavroudi, Irene
-
Hadzidimitriou, ...
-
Stavropoulos-Gio ...
-
Papadaki, Helen ...
-
Stamatopoulos, K ...
-
visa färre...
- Artiklar i publikationen
-
Leukemia and Lym ...
- Av lärosätet
-
Uppsala universitet