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  • Fallaize, RosalindUniv Reading, Hugh Sinclair Unit Human Nutr, Reading RG6 6AP, Berks, England.;Univ Reading, Inst Cardiovasc & Metab Res, Reading RG6 6AP, Berks, England.;Univ Hertfordshire, Sch Life & Med Sci, Coll Lane, Hatfield AL10 9AB, Herts, England. (author)

APOE genotype influences insulin resistance, apolipoprotein CII and CIII according to plasma fatty acid profile in the Metabolic Syndrome

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-07-24
  • Springer Science and Business Media LLC,2017
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-333525
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-333525URI
  • https://doi.org/10.1038/s41598-017-05802-2DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Metabolic markers associated with the Metabolic Syndrome (MetS) may be affected by interactions between the APOE genotype and plasma fatty acids (FA). In this study, we explored FA-gene interactions between the missense APOE polymorphisms and FA status on metabolic markers in MetS. Plasma FA, blood pressure, insulin sensitivity and lipid concentrations were determined at baseline and following a 12-week randomized, controlled, parallel, dietary FA intervention in 442 adults with MetS (LIPGENE study). FA-APOE gene interactions at baseline and following change in plasma FA were assessed using adjusted general linear models. At baseline E4 carriers had higher plasma concentrations of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apo B) compared with E2 carriers; and higher TC, LDL-C and apo B compared with E3/E3. Whilst elevated plasma n-3 polyunsaturated FA (PUFA) was associated with a beneficially lower concentration of apo CIII in E2 carriers, a high proportion of plasma C16:0 was associated with insulin resistance in E4 carriers. Following FA intervention, a reduction in plasma long-chain n-3 PUFA was associated with a reduction in apo CII concentration in E2 carriers. Our novel data suggest that individuals with MetS may benefit from personalized dietary interventions based on APOE genotype.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Carvalho-Wells, Andrew L.Univ Reading, Hugh Sinclair Unit Human Nutr, Reading RG6 6AP, Berks, England.;Univ Reading, Inst Cardiovasc & Metab Res, Reading RG6 6AP, Berks, England. (author)
  • Tierney, Audrey C.Univ Coll Dublin, Conway Inst, Nutrigen Res Grp, Dublin, Ireland. (author)
  • Marin, CarmenUniv Cordoba, IMIBIC, Reina Sofia Univ Hosp, Lipids & Atherosclerosis Unit, Cordoba, Spain. (author)
  • Kiec-Wilk, BeataUniv Med Coll, Dept Metab Dis, Krakow, Poland. (author)
  • Dembinska-Kiec, AldonaJagiellonian Univ, Dept Clin Biochem, Coll Med, Krakow, Poland. (author)
  • Drevon, Christian A.Univ Oslo, Dept Nutr, Inst Basic Med Sci, Fac Med, Oslo, Norway. (author)
  • DeFoort, CatherineINSERM, Human Nutr & Lipids 476, Marseille, France. (author)
  • Lopez-Miranda, JoseUniv Cordoba, IMIBIC, Reina Sofia Univ Hosp, Lipids & Atherosclerosis Unit, Cordoba, Spain. (author)
  • Risérus, Ulf,1967-Uppsala universitet,Klinisk nutrition och metabolism(Swepub:uu)ulfriser (author)
  • Saris, Wim H.MUMC, Dept Human Biol, NUTRIM Sch Nutr & Translat Res Metab, Maastricht, Netherlands. (author)
  • Blaak, Ellen E.MUMC, Dept Human Biol, NUTRIM Sch Nutr & Translat Res Metab, Maastricht, Netherlands. (author)
  • Roche, Helen M.Univ Coll Dublin, Conway Inst, Nutrigen Res Grp, Dublin, Ireland. (author)
  • Lovegrove, Julie A.Univ Reading, Hugh Sinclair Unit Human Nutr, Reading RG6 6AP, Berks, England.;Univ Reading, Inst Cardiovasc & Metab Res, Reading RG6 6AP, Berks, England. (author)
  • Univ Reading, Hugh Sinclair Unit Human Nutr, Reading RG6 6AP, Berks, England.;Univ Reading, Inst Cardiovasc & Metab Res, Reading RG6 6AP, Berks, England.;Univ Hertfordshire, Sch Life & Med Sci, Coll Lane, Hatfield AL10 9AB, Herts, England.Univ Reading, Hugh Sinclair Unit Human Nutr, Reading RG6 6AP, Berks, England.;Univ Reading, Inst Cardiovasc & Metab Res, Reading RG6 6AP, Berks, England. (creator_code:org_t)

Related titles

  • In:Scientific Reports: Springer Science and Business Media LLC72045-2322

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