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  • Chan, SherwinKarolinska Institutet (author)

Regulation of PfEMP1-VAR2CSA translation by a Plasmodium translation-enhancing factor

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-05-08
  • Springer Science and Business Media LLC,2017
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-333532
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-333532URI
  • https://doi.org/10.1038/nmicrobiol.2017.68DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:136386855URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Pregnancy-associated malaria commonly involves the binding of Plasmodium falciparum-infected erythrocytes to placental chondroitin sulfate A (CSA) through the PfEMP1-VAR2CSA protein. VAR2CSA is translationally repressed by an upstream open reading frame. In this study, we report that the P. falciparum translation enhancing factor (PTEF) relieves upstream open reading frame repression and thereby facilitates VAR2CSA translation. VAR2CSA protein levels in var2csa-transcribing parasites are dependent on the expression level of PTEF, and the alleviation of upstream open reading frame repression requires the proteolytic processing of PTEF by PfCalpain. Cleavage generates a C-terminal domain that contains a sterile-alpha-motif-like domain. The C-terminal domain is permissive to cytoplasmic shuttling and interacts with ribosomes to facilitate translational derepression of the var2csa coding sequence. It also enhances translation in a heterologous translation system and thus represents the first non-canonical translation enhancing factor to be found in a protozoan. Our results implicate PTEF in regulating placental CSA binding of infected erythrocytes.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Frasch, AlejandraKarolinska Institutet (author)
  • Mandava, Chandra Sekhar,1978-Uppsala universitet,Struktur- och molekylärbiologi(Swepub:uu)chsma839 (author)
  • Ch'ng, Jun-HongKarolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, Box 280,Nobels Vag 16, S-17177 Stockholm, Sweden.;Natl Univ Singapore, Dept Microbiol, Singapore 117545, Singapore. (author)
  • del Pilar Quintana, MariaKarolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, Box 280,Nobels Vag 16, S-17177 Stockholm, Sweden.;Univ Rosario, Fac Ciencias Nat & Matemat, Escuela Med & Ciencias Salud, Calle 12C 6-25, Bogota, Colombia. (author)
  • Vesterlund, MattiasKarolinska Institutet (author)
  • Ghorbal, MehdiUniv Montpellier, Lab Parasitol Mycol, Fac Med, F-34090 Montpellier, France.;Univ Montpellier, UMR MiVEGEC, IRD 224, CNRS 5290, Montpellier, France. (author)
  • Joannin, NicolasKarolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, Box 280,Nobels Vag 16, S-17177 Stockholm, Sweden. (author)
  • Franzen, OscarKarolinska Institutet (author)
  • Lopez-Rubio, Jose-JuanUniv Montpellier, Lab Parasitol Mycol, Fac Med, F-34090 Montpellier, France.;Univ Montpellier, UMR MiVEGEC, IRD 224, CNRS 5290, Montpellier, France. (author)
  • Barbieri, SoniaUniv Svizzera Italiana, Inst Res Biomed, CH-6500 Bellinzona, Switzerland. (author)
  • Lanzavecchia, AntonioUniv Svizzera Italiana, Inst Res Biomed, CH-6500 Bellinzona, Switzerland.;ETH, Inst Microbiol, CH-8093 Zurich, Switzerland. (author)
  • Sanyal, SuparnaUppsala universitet,Struktur- och molekylärbiologi(Swepub:uu)sucsa102 (author)
  • Wahlgren, MatsKarolinska Institutet (author)
  • Karolinska InstitutetStruktur- och molekylärbiologi (creator_code:org_t)

Related titles

  • In:Nature Microbiology: Springer Science and Business Media LLC2:72058-5276

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