Search: WFRF:(Perheentupa A.) >
Identification of e...
Identification of endothelin-converting enzyme-2 as an autoantigen in autoimmune polyendocrine syndrome type 1
-
- Smith-Anttila, Casey J. A. (author)
- Uppsala universitet,Genetisk utvecklingsbiologi,Univ Newcastle, John Hunter Childrens Hosp, Dept Paediat Endocrinol & Diabet, Newcastle, NSW, Australia.;Univ Newcastle, Fac Hlth & Med, Newcastle, NSW, Australia.;Univ Melbourne, Dept Anat & Neurosci, Melbourne, Vic, Australia.
-
- Bensing, Sophie (author)
- Karolinska Institutet,Uppsala universitet,Autoimmunitet,Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.
-
- Alimohammadi, Mohammad (author)
- Uppsala universitet,Dermatologi och venereologi
-
show more...
-
- Dalin, Frida, 1984- (author)
- Uppsala universitet,Dermatologi och venereologi,Karolinska Inst, Ctr Mol Med, Dept Med Solna, Stockholm, Sweden.
-
- Oscarson, Mikael (author)
- Karolinska Institutet
-
- Zhang, Ming-Dong (author)
- Karolinska Institutet
-
- Perheentupa, Jaakko (author)
- Helsinki Univ Hosp, Hosp Children & Adolescents, Helsinki, Finland.
-
- Husebye, Eystein S. (author)
- Univ Bergen, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Dept Med, Bergen, Norway.
-
- Gustafsson, Jan, 1948- (author)
- Uppsala universitet,Barnendokrinologisk forskning,U
-
- Björklund, Peyman (author)
- Uppsala universitet,Experimentell kirurgi
-
- Fransson, Anette (author)
- Karolinska Institutet
-
- Nordmark, Gunnel (author)
- Uppsala universitet,Reumatologi
-
- Rönnblom, Lars (author)
- Uppsala universitet,Reumatologi
-
- Meloni, Antonella (author)
- Univ Cagliari, Dept Biomed Biotechnol Sci, Cagliari, Italy.
-
- Scott, Rodney J. (author)
- Univ Newcastle, Informat Based Med, Hunter Med Res Inst, Newcastle, NSW, Australia.;Univ Newcastle, Sch Biomed Sci, Fac Hlth & Med, Newcastle, NSW, Australia.;Hunter Area Pathol Serv, Div Mol Med, Newcastle, NSW, Australia.
-
- Hokfelt, Tomas (author)
- Karolinska Institutet
-
- Crock, Patricia A. (author)
- Univ Newcastle, John Hunter Childrens Hosp, Dept Paediat Endocrinol & Diabet, Newcastle, NSW, Australia.;Univ Newcastle, Fac Hlth & Med, Newcastle, NSW, Australia.
-
- Kämpe, Olle, 1956- (author)
- Karolinska Institutet,Uppsala universitet,Autoimmunitet,Karolinska Inst, Ctr Mol Med, Dept Med Solna, Stockholm, Sweden.;Hunter Area Pathol Serv, Div Mol Med, Newcastle, NSW, Australia.
-
show less...
-
(creator_code:org_t)
- 2017-05-30
- 2017
- English.
-
In: Autoimmunity. - : Informa UK Limited. - 0891-6934 .- 1607-842X. ; 50:4, s. 223-231
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Autoimmune polyendocrine syndrome type 1 (APS1) is a rare monogenic autoimmune disorder caused by mutations in the autoimmune regulator (AIRE) gene. High titer autoantibodies are a characteristic feature of APS1 and are often associated with particular disease manifestations. Pituitary deficits are reported in up to 7% of all APS1 patients, with immunoreactivity to pituitary tissue frequently reported. We aimed to isolate and identify specific pituitary autoantigens in patients with APS1. Immunoscreening of a pituitary cDNA expression library identified endothelin-converting enzyme (ECE)-2 as a potential candidate autoantigen. Immunoreactivity against ECE-2 was detected in 46% APS1 patient sera, with no immunoreactivity detectable in patients with other autoimmune disorders or healthy controls. Quantitative-PCR showed ECE-2 mRNA to be most abundantly expressed in the pancreas with high levels also in the pituitary and brain. In the pancreas ECE-2 was co-expressed with insulin or somatostatin, but not glucagon and was widely expressed in GH producing cells in the guinea pig pituitary. The correlation between immunoreactivity against ECE-2 and the major recognized clinical phenotypes of APS1 including hypopituitarism was not apparent. Our results identify ECE-2 as a specific autoantigen in APS1 with a restricted neuroendocrine distribution.
Subject headings
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Keyword
- APS1
- endothelin-converting enzyme-2
- ECE-2
- pituitary autoantibodies
- pancreas
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Smith-Anttila, C ...
-
Bensing, Sophie
-
Alimohammadi, Mo ...
-
Dalin, Frida, 19 ...
-
Oscarson, Mikael
-
Zhang, Ming-Dong
-
show more...
-
Perheentupa, Jaa ...
-
Husebye, Eystein ...
-
Gustafsson, Jan, ...
-
Björklund, Peyma ...
-
Fransson, Anette
-
Nordmark, Gunnel
-
Rönnblom, Lars
-
Meloni, Antonell ...
-
Scott, Rodney J.
-
Hokfelt, Tomas
-
Crock, Patricia ...
-
Kämpe, Olle, 195 ...
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Biological Scien ...
-
and Immunology
- Articles in the publication
-
Autoimmunity
- By the university
-
Uppsala University
-
Karolinska Institutet