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Long-term follow-up...
Long-term follow-up in primary Sjögren's syndrome reveals differences in clinical presentation between female and male patients
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- Sepulveda, Jorge I. Ramirez (author)
- Karolinska Univ Hosp, Karolinska Inst, Dept Med, Unit Expt Rheumatol, SE-17176 Stockholm, Sweden.,Karolinska University Hospital, Sweden
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- Kvarnstrom, Marika (author)
- Karolinska Institutet
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- Eriksson, Per (author)
- Linköpings universitet,Avdelningen för neuro- och inflammationsvetenskap,Medicinska fakulteten,Region Östergötland, Reumatologiska kliniken i Östergötland,Linköping Univ, Div Rheumatol, Dept Clin Expt Med, Linköping, Sweden.
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- Mandl, Thomas (author)
- Skane Univ Hosp, Dept Rheumatol, Malmö, Sweden.,Skåne University Hospital, Sweden
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- Norheim, Katrine Braekke (author)
- Stavanger Univ Hosp, Dept Internal Med, Clin Immunol Unit, Stavanger, Norway.,Stavanger University Hospital, Norway
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- Johnsen, Svein Joar (author)
- Stavanger Univ Hosp, Dept Internal Med, Clin Immunol Unit, Stavanger, Norway.,Stavanger University Hospital, Norway
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- Hammenfors, Daniel (author)
- Univ Bergen, Dept Clin Sci, Broegelmann Res Lab, Bergen, Norway.;Haukeland Hosp, Dept Rheumatol, Bergen, Norway.,University of Bergen, Norway; Haukeland Hospital, Norway
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- Jonsson, Malin V. (author)
- Univ Bergen, Dept Clin Sci, Broegelmann Res Lab, Bergen, Norway.;Univ Bergen, Sect Oral & Maxillofacial Radiol, Dept Clin Dent, Bergen, Norway.,University of Bergen, Norway; University of Bergen, Norway
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- Skarstein, Kathrine (author)
- Univ Bergen, Dept Clin Med, Gade Lab Pathol, Bergen, Norway.;Haukeland Hosp, Dept Pathol, Bergen, Norway.,University of Bergen, Norway; Haukeland Hospital, Norway
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- Brun, Johan G. (author)
- Univ Bergen, Dept Clin Sci, Broegelmann Res Lab, Bergen, Norway.;Haukeland Hosp, Dept Rheumatol, Bergen, Norway.,University of Bergen, Norway; Haukeland Hospital, Norway
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- Rönnblom, Lars (author)
- Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab,Uppsala University, Sweden
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- Forsblad-d'Elia, Helena (author)
- Umeå universitet,Reumatologi,Umeå University, Sweden,Umeå Univ, Dept Publ Hlth & Clin Med, Rheumatol, Umeå, Sweden.
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- Bucher, Sara Magnusson (author)
- Örebro Univ, Fac Med & Hlth, Dept Rheumatol, Örebro, Sweden.,Örebro University, Sweden
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- Baecklund, Eva, 1956- (author)
- Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab,Uppsala University, Sweden
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- Theander, Elke (author)
- Skane Univ Hosp, Dept Rheumatol, Malmö, Sweden.,Skåne University Hospital, Sweden
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- Omdal, Roald (author)
- Stavanger Univ Hosp, Dept Internal Med, Clin Immunol Unit, Stavanger, Norway.,Stavanger University Hospital, Norway
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- Jonsson, Roland (author)
- Univ Bergen, Dept Clin Sci, Broegelmann Res Lab, Bergen, Norway.;Haukeland Hosp, Dept Rheumatol, Bergen, Norway.,University of Bergen, Norway; Haukeland Hospital, Norway
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- Nordmark, Gunnel (author)
- Uppsala universitet,Reumatologi,Science for Life Laboratory, SciLifeLab,Uppsala University, Sweden
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- Wahren-Herlenius, Marie (author)
- Karolinska Institutet
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- Meadows, Jennifer (contributor)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,DISSECT consortium
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- Dahlqvist, Johanna, 1979- (contributor)
- Uppsala universitet,Reumatologi,DISSECT consortium
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Karolinska Univ Hosp, Karolinska Inst, Dept Med, Unit Expt Rheumatol, SE-17176 Stockholm, Sweden Karolinska University Hospital, Sweden (creator_code:org_t)
- 2017-08-08
- 2017
- English.
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In: Biology of Sex Differences. - : BioMed Central. - 2042-6410. ; 8
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Abstract
Subject headings
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- Background: Despite men being less prone to develop autoimmune diseases, male sex has been associated with a more severe disease course in several systemic autoimmune diseases. In the present study, we aimed to investigate differences in the clinical presentation of primary Sjogren's syndrome (pSS) between the sexes and establish whether male sex is associated with a more severe form of long-term pSS. Methods: Our study population included 967 patients with pSS (899 females and 68 males) from Scandinavian clinical centers. The mean follow-up time (years) was 8.8 +/- 7.6 for women and 8.5 +/- 6.2 for men (ns). Clinical data including serological and hematological parameters and glandular and extraglandular manifestations were compared between men and women. Results: Male patient serology was characterized by more frequent positivity for anti-Ro/SSA and anti-La/SSB (p = 0. 02), and ANA (p = 0.02). Further, men with pSS were more frequently diagnosed with interstitial lung disease (p = 0. 008), lymphadenopathy (p = 0.04) and lymphoma (p = 0.007). Conversely, concomitant hypothyroidism was more common among female patients (p = 0.009). Conclusions: We observe enhanced serological responses and higher frequencies of lymphoma-related extraglandular manifestations in men with pSS. Notably, lymphoma itself was also significantly more common in men. These observations may reflect an aggravated immune activation and a more severe pathophysiological state in male patients with pSS and indicate a personalized managing of the disease due to the influence of the sex of patients with pSS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Sjogren's syndrome
- Autoimmunity
- Sex difference
- Disease severity
- Extraglandular manifestations
Publication and Content Type
- ref (subject category)
- art (subject category)
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Sepulveda, Jorge ...
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Kvarnstrom, Mari ...
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Eriksson, Per
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Mandl, Thomas
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Norheim, Katrine ...
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Johnsen, Svein J ...
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show more...
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Hammenfors, Dani ...
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Jonsson, Malin V ...
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Skarstein, Kathr ...
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Brun, Johan G.
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Rönnblom, Lars
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Forsblad-d'Elia, ...
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Bucher, Sara Mag ...
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Baecklund, Eva, ...
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Theander, Elke
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Omdal, Roald
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Jonsson, Roland
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Nordmark, Gunnel
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Wahren-Herlenius ...
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Meadows, Jennife ...
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Dahlqvist, Johan ...
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- About the subject
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Rheumatology and ...
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MEDICAL AND HEAL ...
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and Surgery
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Biology of Sex D ...
- By the university
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Uppsala University
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Umeå University
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Linköping University
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Karolinska Institutet