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Dietary Pattern Spe...
Dietary Pattern Specific Protein Biomarkers for Cardiovascular Disease : A Cross-Sectional Study in 2 Independent Cohorts
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- Warensjö Lemming, Eva (författare)
- Uppsala universitet,Uppsala University,Ortopedi
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- Byberg, Liisa (författare)
- Uppsala universitet,Uppsala University,Ortopedi
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- Stattin, Karl (författare)
- Uppsala universitet,Uppsala University,Ortopedi
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- Ahmad, Shafqat (författare)
- Uppsala universitet,Uppsala University,Harvard T.H. Chan School of Public Health,Brigham and Women's Hospital / Harvard Medical School,Molekylär epidemiologi,Harvard Med Sch, Prevent Med Div, Brigham & Womens Hosp, Boston, MA USA; Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA
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- Lind, Lars (författare)
- Uppsala universitet,Uppsala University,Klinisk epidemiologi
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- Elmståhl, Sölve (författare)
- Lund University,Lunds universitet,Geriatrik,Forskargrupper vid Lunds universitet,Geriatrics,Lund University Research Groups,Lund Univ, Dept Clin Sci, Div Geriatr Med, Lund, Sweden
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- Larsson, Susanna C. (författare)
- Uppsala universitet,Karolinska Institutet,Uppsala University,Karolinska Institute,Ortopedi,Karolinska Inst, Div Nutr Epidemiol, Inst Environm Med, Stockholm, Sweden
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- Wolk, Alicja (författare)
- Uppsala universitet,Karolinska Institutet,Uppsala University,Karolinska Institute,Ortopedi,Karolinska Inst, Div Nutr Epidemiol, Inst Environm Med, Stockholm, Sweden
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- Michaëlsson, Karl, 1959- (författare)
- Uppsala universitet,Uppsala University,Ortopedi
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(creator_code:org_t)
- American Heart Association (AHA), 2019
- 2019
- Engelska.
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Ingår i: Journal of the American Heart Association. - : American Heart Association (AHA). - 2047-9980. ; 8:11
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: Mechanisms related to the influence of diet on the development of cardiovascular disease are not entirely understood, and protein biomarkers may help to understand these pathways. Studies of biomarkers identified with multiplex proteomic methods and dietary patterns are largely lacking. Methods and Results: Dietary patterns were generated through principal component analysis in 2 population-based Swedish cohorts, the EpiHealth (EpiHealth study; n=20 817 men and women) and the SMCC (Swedish Mammography Cohort Clinical [n=4650 women]). A set of 184 protein cardiovascular disease biomarkers were measured with 2 high-throughput, multiplex immunoassays. Discovery and replication multivariable linear regression analyses were used to investigate the associations between the principal component analysis–generated dietary patterns and the cardiovascular disease–associated protein biomarkers, first in the EpiHealth (n=2240) and then in the Swedish Mammography Cohort Clinical. Four main dietary patterns were identified in the EpiHealth, and 3 patterns were identified in the Swedish Mammography Cohort Clinical. The healthy and the Western/traditional patterns were found in both cohorts. In the EpiHealth, 57 protein biomarkers were associated with 3 of the dietary patterns, and 41 of these associations were replicated in the Swedish Mammography Cohort Clinical, with effect estimates ranging from 0.057 to 0.083 (P-value range, 5.0×10−2–1.4×10−9) for each SD increase in the relative protein concentration. Independent associations were established between dietary patterns and the 21 protein biomarkers. Two proteins, myeloperoxidase and resistin, were associated with both the healthy and the light meal pattern but in opposite directions. Conclusions: We have discovered and replicated independent associations between dietary patterns and 21 biomarkers linked to cardiovascular disease, which have a role in the pathways related to inflammation, endothelial and immune function, cell adhesion, and metabolism.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- cardiovascular disease
- dietary patterns
- EpiHealth study
- inflammation
- proteomics
- Swedish Mammography Cohort Clinical
- cardiovascular disease
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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