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Occurrence of Hybri...
Occurrence of Hybrid Escherichia coli Strains Carrying Shiga Toxin and Heat-Stable Toxin in Livestock of Bangladesh
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- Johura, Fatema-Tuz (författare)
- Bangladesh (Icddr,b), International Center for Diarrheal Disease Research
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- Parveen, Rozina (författare)
- Bangladesh (icddr,b), International Center for Diarrheal Disease Research
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- Islam, Atiqul (författare)
- Bangladesh (icddr,b), International Center for Diarrheal Disease Research
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- Sadique, Abdus (författare)
- Bangladesh (icddr,b), International Center for Diarrheal Disease Research
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- Rahim, Md Niaz (författare)
- Bangladesh (icddr,b), International Center for Diarrheal Disease Research
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- Monira, Shirajum (författare)
- Bangladesh (icddr,b), International Center for Diarrheal Disease Research
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- Khan, Anisur R. (författare)
- University of Dhaka, Department of Microbiology
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- Ahsan, Sunjukta (författare)
- University of Dhaka, Department of Microbiology
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- Ohnishi, Makoto (författare)
- National Institute of Infectious Diseases, Tokyo
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- Watanabe, Haruo (författare)
- National Institute of Infectious Diseases, Tokyo
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- Chakraborty, Subhra (författare)
- Johns Hopkins Bloomberg School of Public Health
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- George, Christine M. (författare)
- Johns Hopkins Bloomberg School of Public Health
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- Cravioto, Alejandro (författare)
- Bangladesh (icddr,b), International Center for Diarrheal Disease Research
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- Navarro, Armando (författare)
- Universidad Nacional Autónoma de Mexico, Faculty of Medicine, Department of Public Health
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- Hasan, Badrul, 1984- (författare)
- Uppsala universitet,Infektionssjukdomar
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- Alam, Munirul (författare)
- Bangladesh (Icddr,b), International Center for Diarrheal Disease Research
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(creator_code:org_t)
- 2017-01-09
- 2017
- Engelska.
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Ingår i: Frontiers in Public Health. - : Frontiers Media SA. - 2296-2565. ; 4
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.frontier...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Shiga toxin-producing Escherichia coli (STEC) and enterotoxigenic E. coli (ETEC) are important causes of diarrhea in humans and animals worldwide. Although ruminant animals are the main source of STEC, diarrhea due to this pathotype is very low in Bangladesh where ETEC remains the predominant group associated with childhood diarrhea. In the present study, E. coli strains (n = 35) isolated from Bangladesh livestock (goats, sheep, and cattle) and poultry (chicken and ducks) were analyzed for the presence of major virulence factors, such as Shiga toxins (STX-1 and STX-2), heat-labile toxin, and heat-stable toxins (STa and STb). Multiplex polymerase chain reaction results revealed 23 (66%) E. coli strains to be virulent possessing either sta (n = 5), stx (stx1, n = 8; stx2, n = 2), or both (n = 8) genes in varying combinations. Thirty-four percent (8/23) of strains from livestock were hybrid type that carried both stx (either stx1 or stx2) and ETEC-specific enterotoxin gene sta. Serotyping results revealed that the ETEC strains belonged to five serotypes, namely O36: H5, O174: H-, O152: H8, O109: H51, and O8: H21, while the STEC-producing strains belonged to serotypes O76: H19 (n = 3), O43: H2 (n = 2), O87: H16 (n = 2), OR: H2 (n = 1), O110: H16 (n = 1), and O152: H8 (n = 1). The STEC-ETEC hybrid strains belonged to serotypes O76: H19 (n = 3), O43: H2 (n = 2), O87: H16, OR: H2, and O152: H8. Forty percent (2/5) of the ETEC and 20% (2/10) of the STEC strains were multidrug resistant with the highest drug resistance (50%) being found in the hybrid strains. Molecular fingerprinting determined by pulsed-field gel electrophoresis and cluster analyses by dendrogram revealed that, genetically, STEC-ETEC hybrid strains were highly heterogeneous. Multidrug-resistant E. coli STEC-ETEC hybrid strains in domesticated animals pose a public health threat for humans in Bangladesh.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Shiga-toxin
- enterotoxin
- livestock
- hybrid
- multidrug resistant
- PFGE
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Johura, Fatema-T ...
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Parveen, Rozina
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Islam, Atiqul
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Sadique, Abdus
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Rahim, Md Niaz
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Monira, Shirajum
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Khan, Anisur R.
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Ahsan, Sunjukta
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Ohnishi, Makoto
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Watanabe, Haruo
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Chakraborty, Sub ...
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George, Christin ...
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Cravioto, Alejan ...
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Navarro, Armando
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Hasan, Badrul, 1 ...
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Alam, Munirul
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