Sökning: L773:1471 4906 OR L773:1471 4981 >
Positive and Negati...
Positive and Negative Signals in Mast Cell Activation
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- Bulfone-Paus, Silvia (författare)
- Univ Manchester, Div Musculoskeletal & Dermatol Sci, Fac Biol Med & Hlth, Manchester, Lancs, England.
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- Nilsson, Gunnar (författare)
- Karolinska Institutet,Uppsala universitet,Hematologi,Karolinska Inst, Dept Med, Immunol & Allergy Unit, Stockholm, Sweden.;Karolinska Univ Hosp, Stockholm, Sweden
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- Draber, Petr (författare)
- Acad Sci Czech Republ, Inst Mol Genet, Dept Signal Transduct, Prague, Czech Republic.
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- Blank, Ulrich (författare)
- INSERM, U1149, Ctr Rech Inflammat, Paris, France.;CNRS, ERL8252, Paris, France.;Univ Paris Diderot, Sorbonne Paris Cite, Fac Med, Site Xavier Bichat,Inflamex Lab Excellence, Paris, France.
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- Levi-Schaffer, Francesca (författare)
- Hebrew Univ Jerusalem, Inst Drug Res, Sch Pharm, Fac Med,Pharmacol & Expt Therapeut Unit, Jerusalem, Israel.
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Univ Manchester, Div Musculoskeletal & Dermatol Sci, Fac Biol Med & Hlth, Manchester, Lancs, England Hematologi (creator_code:org_t)
- Elsevier BV, 2017
- 2017
- Engelska.
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Ingår i: Trends in immunology. - : Elsevier BV. - 1471-4906 .- 1471-4981. ; 38:9, s. 657-667
- Relaterad länk:
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https://www.research...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Mast cells are powerful immune modulators of the tissue microenvironment. Within seconds of activation, these cells release a variety of preformed biologically active products, followed by a wave of mediator synthesis and secretion. Increasing evidence suggests that an intricate network of inhibitory and activating receptors, specific signaling pathways, and adaptor proteins governs mast cell responsiveness to stimuli. Here, we discuss the biological and clinical relevance of negative and positive signaling modalities that control mast cell activation, with an emphasis on novel Fc epsilon RI regulators, immunoglobulin E (IgE)-independent pathways [e.g., Mas-related G protein-coupled receptor X2 (MRGPRX2)], tetraspanins, and the CD300 family of inhibitory and activating receptors.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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