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  • Staiger, E. A.Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Cornell Univ, Dept Anim Sci, Ithaca, NY 14853 USA. (author)

The evolutionary history of the DMRT3 'Gait keeper' haplotype

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • 2017-07-25
  • WILEY,2017
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-335121
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-335121URI
  • https://doi.org/10.1111/age.12580DOI
  • https://res.slu.se/id/publ/91114URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • A previous study revealed a strong association between the DMRT3:Ser301STOP mutation in horses and alternate gaits as well as performance in harness racing. Several follow-up studies have confirmed a high frequency of the mutation in gaited horse breeds and an effect on gait quality. The aim of this study was to determine when and where the mutation arose, to identify additional potential causal mutations and to determine the coalescence time for contemporary haplotypes carrying the stop mutation. We utilized sequences from 89 horses representing 26 breeds to identify 102 SNPs encompassing the DMRT3 gene that are in strong linkage disequilibrium with the stop mutation. These 102 SNPs were genotyped in an additional 382 horses representing 72 breeds, and we identified 14 unique haplotypes. The results provided conclusive evidence that DMRT3: Ser301STOP is causal, as no other sequence polymorphisms showed an equally strong association to locomotion traits. The low sequence diversity among mutant chromosomes demonstrated that they must have diverged from a common ancestral sequence within the last 10 000 years. Thus, the mutation occurred either just before domestication or more likely some time after domestication and then spread across the world as a result of selection on locomotion traits.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Mikko, SofiaSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,Swedish Univ Agr Sci, Dept Anim Breeding & Genet, SE-75007 Uppsala, Sweden.(Swepub:slu)47662 (author)
  • Promerova, M.Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Max Planck Inst Sci Human Hist, Dept Archaeogenet, D-07745 Jena, Germany. (author)
  • Brooks, S.Univ Florida, Dept Anim Sci, Gainesville, FL 32611 USA. (author)
  • Cothran, E. G.Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Vet Integrat Biosci, College Stn, TX 77843 USA. (author)
  • Imsland, F.Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi (author)
  • Fegraeus, K. JaderkvistSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,Swedish Univ Agr Sci, Dept Anim Breeding & Genet, SE-75007 Uppsala, Sweden.(Swepub:slu)96355 (author)
  • Lindgren, GabriellaSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,Swedish Univ Agr Sci, Dept Anim Breeding & Genet, SE-75007 Uppsala, Sweden.(Swepub:slu)51014 (author)
  • Yeganeh, H. MehrabaniUniv Tehran, Dept Anim Sci, Tehran 54500, Iran. (author)
  • Mikko, S.Swedish Univ Agr Sci, Dept Anim Breeding & Genet, SE-75007 Uppsala, Sweden. (author)
  • Vega-Pla, J. L.Cria Caballar Fuerzas Armadas, Lab Invest Aplicada, Cordoba 14080, Spain. (author)
  • Tozaki, T.Lab Racing Chem, Genet Anal Dept, Utsunomiya, Tochigi 3200851, Japan. (author)
  • Rubin, Carl-JohanUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)carub021 (author)
  • Andersson, LeifSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Vet Integrat Biosci, College Stn, TX 77843 USA.;Swedish Univ Agr Sci, Dept Anim Breeding & Genet, SE-75007 Uppsala, Sweden.,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,Texas A&M University,Uppsala University(Swepub:slu)48730 (author)
  • Uppsala universitetInstitutionen för medicinsk biokemi och mikrobiologi (creator_code:org_t)
  • Sveriges lantbruksuniversitet

Related titles

  • In:Animal Genetics: WILEY48:5, s. 551-5590268-91461365-2052

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