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Results after surgi...
Results after surgical treatment of liver metastases in patients with high-grade gastroenteropancreatic neuroendocrine carcinomas
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- Galleberg, R. B. (author)
- Haukeland Hosp, Dept Oncol, N-5021 Bergen, Norway.
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- Knigge, U. (author)
- Univ Copenhagen, Dept Surg C, Rigshosp, Copenhagen, Denmark.;Univ Copenhagen, Dept Endocrinol PE, Rigshosp, Copenhagen, Denmark.
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- Tiensuu Janson, Eva (author)
- Uppsala universitet,Onkologisk endokrinologi
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- Vestermark, L. W. (author)
- Odense Univ Hosp, Dept Oncol, Odense, Denmark.
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Haugvik, S. -P (author)
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- Ladekarl, M. (author)
- Aarhus Univ Hosp, Dept Oncol, Aarhus, Denmark.
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- Langer, S. W. (author)
- Univ Copenhagen, Dept Oncol, Rigshosp, Copenhagen, Denmark.
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- Gronbaek, H. (author)
- Aarhus Univ Hosp, Dept Hepatol & Gastroenterol, Aarhus, Denmark.
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- Osterlund, P. (author)
- Univ Helsinki, Dept Oncol, Cent Hosp, Helsinki, Finland.
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- Hjortland, G. O. (author)
- Oslo Univ Hosp, Dept Oncol, Oslo, Norway.
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- Assmus, J. (author)
- Haukeland Hosp, Ctr Clin Res, Bergen, Norway.
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- Tang, L. (author)
- MSKCC, Dept Pathol, New York, NY USA.
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- Perren, A. (author)
- Univ Bern, Dept Pathol, Bern, Switzerland.
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- Sorbye, H. (author)
- Haukeland Hosp, Dept Oncol, N-5021 Bergen, Norway.;Univ Bergen, Dept Clin Sci, Bergen, Norway.
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Haukeland Hosp, Dept Oncol, N-5021 Bergen, Norway Univ Copenhagen, Dept Surg C, Rigshosp, Copenhagen, Denmark.;Univ Copenhagen, Dept Endocrinol PE, Rigshosp, Copenhagen, Denmark. (creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
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In: European Journal of Surgical Oncology. - : Elsevier BV. - 0748-7983 .- 1532-2157. ; 43:9, s. 1682-1689
- Related links:
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https://helda.helsin...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background: Gastroenteropancreatic neuroendocrine carcinomas (GEP-NEC) are generally characterized by synchronous metastases, high aggressiveness and a dismal prognosis. Current international guidelines do not recommend surgical treatment of liver metastases, however the existing data are scarce. The aim of this study was to evaluate the results of curatively intended resection/radiofrequency ablation (RFA) of liver metastases in patients with metastatic GEP-NEC. Methods: 32 patients with a diagnosis of high-grade gastroenteropancreatic neuroendocrine neoplasm (Ki-67 > 20%) and with intended curative resection/RFA of liver metastases, were identified among 840 patients from two Nordic GEP-NEC registries. Tumor morphology (well vs poor differentiation) was reassessed. Overall survival (OS) and progression-free survival (PFS) was assessed by Kaplan Meier analyses for the entire cohort and for subgroups. Results: Median OS after resection/RFA of liver metastases was 35.9 months (95% -CI: 20.6-51.3) with a five-year OS of 43%. The median PFS was 8.4 months (95% -CI: 3.9-13). Four patients (13%) were disease -free after 5 years. Two patients had well -differentiated morphology (NET G3) and 20 patients (63%) had Ki-67 >= 55%. A Ki-67 < 55% and receiving adjuvant chemotherapy were statistically significant factors of improved OS after liver resection/RFA. Conclusion: This study shows a long median and long term survival after liver surgery/RFA for these selected metastatic GEP-NEC patients, particularly for the group with a Ki-67 in the relatively lower G3 range. Our findings indicate a possible role for surgical treatment of liver metastases in the management of this patient population.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Neuroendocrine carcinoma
- Metastases
- Liver
- Surgery
- Survival
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Galleberg, R. B.
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Knigge, U.
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Tiensuu Janson, ...
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Vestermark, L. W ...
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Haugvik, S. -P
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Ladekarl, M.
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Langer, S. W.
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Gronbaek, H.
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Osterlund, P.
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Hjortland, G. O.
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Assmus, J.
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Tang, L.
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Perren, A.
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Sorbye, H.
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and Surgery
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Uppsala University