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Height, selected ge...
Height, selected genetic markers and prostate cancer risk : results from the PRACTICAL consortium.
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Lophatananon, Artitaya (author)
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Stewart-Brown, Sarah (author)
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Kote-Jarai, Zsofia (author)
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Olama, Ali Amin Al (author)
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Garcia, Sara Benlloch (author)
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Neal, David E (author)
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Hamdy, Freddie C (author)
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Donovan, Jenny L (author)
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Giles, Graham G (author)
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Fitzgerald, Liesel M (author)
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Southey, Melissa C (author)
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Pharoah, Paul (author)
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Pashayan, Nora (author)
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- Gronberg, Henrik (author)
- Karolinska Institutet
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- Wiklund, Fredrik (author)
- Karolinska Institutet
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- Aly, Markus (author)
- Karolinska Institutet
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Stanford, Janet L (author)
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Brenner, Hermann (author)
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Dieffenbach, Aida K (author)
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Arndt, Volker (author)
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Park, Jong Y (author)
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Lin, Hui-Yi (author)
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Sellers, Thomas (author)
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Slavov, Chavdar (author)
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Kaneva, Radka (author)
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Mitev, Vanio (author)
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Batra, Jyotsna (author)
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Spurdle, Amanda (author)
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Clements, Judith A (author)
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Easton, Douglas (author)
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Eeles, Rosalind A (author)
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Muir, Kenneth (author)
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(creator_code:org_t)
- 2017-08-01
- 2017
- English.
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In: British Journal of Cancer. - : Springer Science and Business Media LLC. - 0007-0920 .- 1532-1827. ; 117:5, s. 734-743
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- BACKGROUND: Evidence on height and prostate cancer risk is mixed, however, recent studies with large data sets support a possible role for its association with the risk of aggressive prostate cancer.METHODS: We analysed data from the PRACTICAL consortium consisting of 6207 prostate cancer cases and 6016 controls and a subset of high grade cases (2480 cases). We explored height, polymorphisms in genes related to growth processes as main effects and their possible interactions.RESULTS: The results suggest that height is associated with high-grade prostate cancer risk. Men with height >180 cm are at a 22% increased risk as compared to men with height <173 cm (OR 1.22, 95% CI 1.01-1.48). Genetic variants in the growth pathway gene showed an association with prostate cancer risk. The aggregate scores of the selected variants identified a significantly increased risk of overall prostate cancer and high-grade prostate cancer by 13% and 15%, respectively, in the highest score group as compared to lowest score group.CONCLUSIONS: There was no evidence of gene-environment interaction between height and the selected candidate SNPs.Our findings suggest a role of height in high-grade prostate cancer. The effect of genetic variants in the genes related to growth is seen in all cases and high-grade prostate cancer. There is no interaction between these two exposures.
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- By the author/editor
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Lophatananon, Ar ...
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Stewart-Brown, S ...
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Kote-Jarai, Zsof ...
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Olama, Ali Amin ...
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Garcia, Sara Ben ...
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Neal, David E
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show more...
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Hamdy, Freddie C
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Donovan, Jenny L
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Giles, Graham G
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Fitzgerald, Lies ...
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Southey, Melissa ...
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Pharoah, Paul
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Pashayan, Nora
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Gronberg, Henrik
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Wiklund, Fredrik
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Aly, Markus
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Stanford, Janet ...
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Brenner, Hermann
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Dieffenbach, Aid ...
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Arndt, Volker
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Park, Jong Y
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Lin, Hui-Yi
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Sellers, Thomas
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Slavov, Chavdar
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Kaneva, Radka
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Mitev, Vanio
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Batra, Jyotsna
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Spurdle, Amanda
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Clements, Judith ...
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Easton, Douglas
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Eeles, Rosalind ...
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Muir, Kenneth
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show less...
- Articles in the publication
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British Journal ...
- By the university
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Uppsala University
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Karolinska Institutet