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  • Öberg, Kjell,1946-Uppsala universitet,Endokrin tumörbiologi (författare)

ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Tumors : Biochemical Markers

  • Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • 2017-04-08
  • S. Karger AG,2017
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-336660
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-336660URI
  • https://doi.org/10.1159/000472254DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Biomarkers have been the mainstay in the diagnosis and follow-up of patients with neuroendocrine tumors (NETs) over the last few decades. In the beginning, secretory products from a variety of subtypes of NETs were regarded as biomarkers to follow during diagnosis and treatment: serotonin for small intestinal (SI) NETs, and gastrin and insulin for pancreatic NETs. However, it became evident that a large number of NETs were so-called nonfunctioning tumors without secreting substances that caused hormone-related symptoms. Therefore, it was necessary to develop so-called "general tumor markers." The most important ones so far have been chromogranin A and neuron-specific enolase (NSE). Chromogranin A is the most important general biomarker for most NETs with a sensitivity and specificity somewhere between 60 and 90%. NSE has been a relevant biomarker for patients with high-grade tumors, particularly lung and gastrointestinal tract tumors. Serotonin and the breakdown product urinary 5-hydroxyindoleacetic acid (U-5-HIAA) is still an important marker for diagnosing and follow-up of SI NETs. Recently, 5-HIAA in plasma has been analyzed by highperformance liquid chromatography and fluorometric detection and has shown good agreement with U-5-HIAA anal ysis. In the future, we will see new tests including circulating tumor cells, circulating DNA and mRNA. Recently, a NET test has been developed analyzing gene transcripts in circulating blood. Preliminary data indicate high sensitivity and specificity for NETs. However, its precise role has to be validated in prospective randomized controlled trials which are ongoing right now.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Couvelard, AnneHospital Beaujon, Department of Pathology (författare)
  • Delle Fave, GianfrancoOspedale Sant’Andrea, Department of Digestive and Liver Disease (författare)
  • Gross, DavidHadassah University Hospital, Department of Endocrinology and Metabolism (författare)
  • Grossman, AshleyUniversity of Oxford, Churchill Hospital, Oxford Centre for Diabetes, Endocrinology and Metabolism (författare)
  • Jensen, Robert T.National Institutes of Health, Digestive Diseases Branch (författare)
  • Pape, Ulrich-FrankCharité University of Berlin, Department of Internal Medicine (författare)
  • Perren, Aurelniversity Hospital Zurich, Department of Pathology (författare)
  • Rindi, GuidoUniversità Cattolica del Sacro Cuore, Policlinico A. Gemelli, Institute of Anatomic Pathology (författare)
  • Ruszniewski, PhilippeBeaujon Hopital, Department of Gastroenterology (författare)
  • Scoazec, Jean-YvesGustave Roussy Institute, Department of Biopathology, Faculty of Medicine Paris Sud (författare)
  • Welin, StaffanUppsala universitet,Onkologisk endokrinologi(Swepub:uu)stafweli (författare)
  • Wiedenmann, BertramCharité University Medicine, Department of Hepatology and Gastroenterology (författare)
  • Ferone, DiegoUniversity of Genova, IRCCS AOU San Martino IST, DiMI, CEBR (författare)
  • Uppsala universitetEndokrin tumörbiologi (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Neuroendocrinology: S. Karger AG105:3, s. 201-2110028-38351423-0194

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