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ENETS Consensus Gui...
ENETS Consensus Guidelines for the Standards of Care in Neuroendocrine Neoplasms : Systemic Therapy - Biotherapy and Novel Targeted Agents
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- Pavel, Marianne (författare)
- Charite Univ Med Berlin, Campus Virchow Klinikum, Dept Hepatol & Gastroenterol
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- Valle, Juan W. (författare)
- Univ Manchester, Inst Canc Sci, Christie NHS Fdn Trust, Dept Med Oncol, Manchester
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- Eriksson, Barbro (författare)
- Uppsala universitet,Endokrin tumörbiologi
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- Rinke, Anja (författare)
- Univ Hosp Marburg UKGM, Div Gastroenterol & Endocrinol
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- Caplin, Martyn (författare)
- Royal Free Hosp, Neuroendocrine Tumour Unit
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- Chen, Jie (författare)
- Sun Yat Sen Univ, Affiliated Hosp 1, Dept Gastroenterol, Guangzhou
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- Costa, Frederico (författare)
- Hosp Sirio Libanes
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- Falkerby, Jenny (författare)
- Uppsala Univ Hosp, Dept Endocrine Oncol
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- Fazio, Nicola (författare)
- European Inst Oncol, Unit Gastrointestinal Med Oncol & Neuroendocrine
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- Gorbounova, Vera (författare)
- Inst Russian Acad Med Sci, Dept Oncol
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- de Herder, Wouter (författare)
- Erasmus MC, ENETS Ctr Excellence Rotterdam, Div Endocrinol, Dept Internal Med
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- Kulke, Matthew (författare)
- Harvard Med Sch, Dana Farber Canc Inst
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- Lombard-Bohas, Catherine (författare)
- Hosp Civils Lyon, Hop Edouard Herriot, Med Oncol Dept
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- O'Connor, Juan (författare)
- Inst Alexander Fleming, Dept Clin Oncol
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- Sorbye, Halfdan (författare)
- Haukeland Hosp, Dept Oncol & Clin Sci
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- Garcia-Carbonero, Rocio (författare)
- Hosp Univ Doce Octubre, Med Oncol Dept
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(creator_code:org_t)
- 2017-03-29
- 2017
- Engelska.
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Ingår i: Neuroendocrinology. - : S. Karger AG. - 0028-3835 .- 1423-0194. ; 105:3, s. 266-280
- Relaterad länk:
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https://www.research...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Systemic therapies established in the management of patients with neuroendocrine tumors (NETs) include somatostatin analogs and interferon-alpha, also referred to as biotherapy. Recent randomized controlled studies have extended the knowledge on the frequency of side effects associated with biotherapy. More recently, novel targeted drugs, such as the mammalian target of rapamycin inhibitor everolimus and the multiple tyrosine kinase inhibitor sunitinib, have been introduced in the management of NETs. Although targeted drugs are generally well tolerated, with most adverse events being of mild to moderate severity and manageable, novel targeted drugs exhibit a distinct adverse event profile that warrants guidance for appropriate diagnostic and therapeutic management. This is particularly important given the widespread and potentially long-term use of everolimus in a broad spectrum of NETs and of sunitinib in pancreatic NETs. This review will focus on the most relevant toxicities associated with biotherapy and novel targeted drugs and on their management. For each drug class indication, administration and dosing schedule, most frequent adverse events, actions and dose adjustments for adverse events as well as their monitoring are presented. This review further covers the evaluation of treatment effect, patient information, drug interactions, and information on pregnancy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Somatostatin analogs
- Interferon-alpha
- Everolimus
- Sunitinib
- Tolerability
- Toxicity
- Dose adjustment
- Drug interaction
- Patient information
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Pavel, Marianne
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Valle, Juan W.
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Eriksson, Barbro
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Rinke, Anja
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Caplin, Martyn
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Chen, Jie
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visa fler...
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Costa, Frederico
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Falkerby, Jenny
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Fazio, Nicola
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Gorbounova, Vera
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de Herder, Woute ...
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Kulke, Matthew
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Lombard-Bohas, C ...
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O'Connor, Juan
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Sorbye, Halfdan
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Garcia-Carbonero ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Neuroendocrinolo ...
- Av lärosätet
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Uppsala universitet