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  • Gentekaki, EleniDalhousie Univ, Dept Biochem & Mol Biol, Halifax, NS, Canada.;Dalhousie Univ, Ctr Comparat Genom & Evolutionary Bioinformat, Halifax, NS, Canada.;Mae Fah Luang Univ, Sch Sci, Chiang Rai, Thailand.;Mae Fah Luang Univ, Human Gut Microbiome Hlth Res Unit, Chiang Rai, Thailand. (författare)

Extreme genome diversity in the hyper-prevalent parasitic eukaryote Blastocystis

  • Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • 2017-09-11
  • PUBLIC LIBRARY SCIENCE,2017
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-336835
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-336835URI
  • https://doi.org/10.1371/journal.pbio.2003769DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Blastocystis is the most prevalent eukaryotic microbe colonizing the human gut, infecting approximately 1 billion individuals worldwide. Although Blastocystis has been linked to intestinal disorders, its pathogenicity remains controversial because most carriers are asymptomatic. Here, the genome sequence of Blastocystis subtype (ST) 1 is presented and compared to previously published sequences for ST4 and ST7. Despite a conserved core of genes, there is unexpected diversity between these STs in terms of their genome sizes, guanine-cytosine (GC) content, intron numbers, and gene content. ST1 has 6,544 protein-coding genes, which is several hundred more than reported for ST4 and ST7. The percentage of proteins unique to each ST ranges from 6.2% to 20.5%, greatly exceeding the differences observed within parasite genera. Orthologous proteins also display extreme divergence in amino acid sequence identity between STs (i.e., 59%-61% median identity), on par with observations of the most distantly related species pairs of parasite genera. The STs also display substantial variation in gene family distributions and sizes, especially for protein kinase and protease gene families, which could reflect differences in virulence. It remains to be seen to what extent these inter-ST differences persist at the intra-ST level. A full 26% of genes in ST1 have stop codons that are created on the mRNA level by a novel polyadenylation mechanism found only in Blastocystis. Reconstructions of pathways and organellar systems revealed that ST1 has a relatively complete membrane-trafficking system and a near-complete meiotic toolkit, possibly indicating a sexual cycle. Unlike some intestinal protistan parasites, Blastocystis ST1 has near-complete de novo pyrimidine, purine, and thiamine biosynthesis pathways and is unique amongst studied stramenopiles in being able to metabolize alpha-glucans rather than beta-glucans. It lacks all genes encoding heme-containing cytochrome P450 proteins. Predictions of the mitochondrion-related organelle (MRO) proteome reveal an expanded repertoire of functions, including lipid, cofactor, and vitamin biosynthesis, as well as proteins that may be involved in regulating mitochondrial morphology and MRO/endoplasmic reticulum (ER) interactions. In sharp contrast, genes for peroxisome-associated functions are absent, suggesting Blastocystis STs lack this organelle. Overall, this study provides an important window into the biology of Blastocystis, showcasing significant differences between STs that can guide future experimental investigations into differences in their virulence and clarifying the roles of these organisms in gut health and disease.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Curtis, Bruce A.Dalhousie Univ, Dept Biochem & Mol Biol, Halifax, NS, Canada.;Dalhousie Univ, Ctr Comparat Genom & Evolutionary Bioinformat, Halifax, NS, Canada. (författare)
  • Stairs, Courtney W.Uppsala universitet,Molekylär evolution,Dalhousie Univ, Dept Biochem & Mol Biol, Halifax, NS, Canada.;Dalhousie Univ, Ctr Comparat Genom & Evolutionary Bioinformat, Halifax, NS, Canada.(Swepub:uu)coust885 (författare)
  • Klimes, VladimirUniv Ostrava, Dept Biol & Ecol, Fac Sci, Ostrava, Czech Republic. (författare)
  • Elias, MarekUniv Ostrava, Dept Biol & Ecol, Fac Sci, Ostrava, Czech Republic. (författare)
  • Salas-Leiva, Dayana E.Dalhousie Univ, Dept Biochem & Mol Biol, Halifax, NS, Canada.;Dalhousie Univ, Ctr Comparat Genom & Evolutionary Bioinformat, Halifax, NS, Canada. (författare)
  • Herman, Emily K.Univ Alberta, Dept Cell Biol, Edmonton, AB, Canada. (författare)
  • Eme, LauraUppsala universitet,Molekylär evolution,Dalhousie Univ, Dept Biochem & Mol Biol, Halifax, NS, Canada.;Dalhousie Univ, Ctr Comparat Genom & Evolutionary Bioinformat, Halifax, NS, Canada.(Swepub:uu)lauem469 (författare)
  • Arias, Maria C.Univ Sci & Technol Lille, Unite Glycobiol Struct & Fonct, CNRS, UMR8576,Cite Sci, Villeneuve Dascq, France. (författare)
  • Henrissat, BernardAix Marseille Univ, CNRS, UMR 7257, Marseille, France.;NRA, USC 1408, AFMB, Marseille, France.;King Abdulaziz Univ, Dept Biol Sci, Jeddah, Saudi Arabia. (författare)
  • Hilliou, FrederiqueUniv Cote Azur, NRA, ISA, Sophia Antipolis, France. (författare)
  • Klute, Mary J.Univ Alberta, Dept Cell Biol, Edmonton, AB, Canada. (författare)
  • Suga, HiroshiPrefectural Univ Hiroshima, Fac Life & Environm Sci, Nanatsuka 562, Shobara, Hiroshima, Japan. (författare)
  • Malik, Shehre-BanooDalhousie Univ, Dept Biochem & Mol Biol, Halifax, NS, Canada.;Dalhousie Univ, Ctr Comparat Genom & Evolutionary Bioinformat, Halifax, NS, Canada. (författare)
  • Pightling, Arthur W.Dalhousie Univ, Dept Biochem & Mol Biol, Halifax, NS, Canada.;US FDA, Ctr Food Safety & Appl Nutr, College Pk, MD USA. (författare)
  • Kolisko, MartinDalhousie Univ, Dept Biochem & Mol Biol, Halifax, NS, Canada.;Dalhousie Univ, Ctr Comparat Genom & Evolutionary Bioinformat, Halifax, NS, Canada.;Czech Acad Sci, Inst Parasitol, Ctr Biol, Ceske Budejovice, Czech Republic. (författare)
  • Rachubinski, Richard A. (författare)
  • Schlacht, Alexander (författare)
  • Soanes, Darren M.Univ Exeter, Coll Life & Environm Sci, Exeter, Devon, England. (författare)
  • Tsaousis, Anastasios D.Dalhousie Univ, Dept Biochem & Mol Biol, Halifax, NS, Canada.;Dalhousie Univ, Ctr Comparat Genom & Evolutionary Bioinformat, Halifax, NS, Canada.;Univ Kent, Lab Mol & Evolutionary Parasitol, RAPID Grp, Sch Biosci, Canterbury, Kent, England. (författare)
  • Archibald, John M.Dalhousie Univ, Dept Biochem & Mol Biol, Halifax, NS, Canada.;Dalhousie Univ, Ctr Comparat Genom & Evolutionary Bioinformat, Halifax, NS, Canada.;Canadian Inst Adv Res, CIFAR Program Integrated Microbial Biodivers, Toronto, ON, Canada. (författare)
  • Ball, Steven G. (författare)
  • Dacks, Joel B.Univ Alberta, Dept Cell Biol, Edmonton, AB, Canada. (författare)
  • Clark, C. GrahamLondon Sch Hyg & Trop Med, Fac Infect & Trop Dis, London, England. (författare)
  • van der Giezen, MarkUniv Exeter, Biosci, Exeter, Devon, England. (författare)
  • Roger, Andrew J.Dalhousie Univ, Dept Biochem & Mol Biol, Halifax, NS, Canada.;Dalhousie Univ, Ctr Comparat Genom & Evolutionary Bioinformat, Halifax, NS, Canada.;Canadian Inst Adv Res, CIFAR Program Integrated Microbial Biodivers, Toronto, ON, Canada. (författare)
  • Dalhousie Univ, Dept Biochem & Mol Biol, Halifax, NS, Canada.;Dalhousie Univ, Ctr Comparat Genom & Evolutionary Bioinformat, Halifax, NS, Canada.;Mae Fah Luang Univ, Sch Sci, Chiang Rai, Thailand.;Mae Fah Luang Univ, Human Gut Microbiome Hlth Res Unit, Chiang Rai, Thailand.Dalhousie Univ, Dept Biochem & Mol Biol, Halifax, NS, Canada.;Dalhousie Univ, Ctr Comparat Genom & Evolutionary Bioinformat, Halifax, NS, Canada. (creator_code:org_t)

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  • Ingår i:PLoS biology: PUBLIC LIBRARY SCIENCE15:91544-91731545-7885

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