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  • Horie, MasafumiUniv Tokyo, Dept Resp Med, Grad Sch Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan.;Univ Tokyo, Div Hlth Serv Promot, Bunkyo Ku, Tokyo, Japan.;RIKEN Ctr Life Sci Technol, DGT, Yokohama, Kanagawa, Japan. (författare)

Integrative CAGE and DNA Methylation Profiling Identify Epigenetically Regulated Genes in NSCLC

  • Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • AMER ASSOC CANCER RESEARCH,2017
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-337081
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-337081URI
  • https://doi.org/10.1158/1541-7786.MCR-17-0191DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Lung cancer is the leading cause of cancer-related deaths worldwide. The majority of cancer driver mutations have been identified; however, relevant epigenetic regulation involved in tumorigenesis has only been fragmentarily analyzed. Epigenetically regulated genes have a great theranostic potential, especially in tumors with no apparent driver mutations. Here, epigenetically regulated genes were identified in lung cancer by an integrative analysis of promoter-level expression profiles from Cap Analysis of Gene Expression (CAGE) of 16 nonsmall cell lung cancer (NSCLC) cell lines and 16 normal lung primary cell specimens with DNA methylation data of 69 NSCLC cell lines and 6 normal lung epithelial cells. A core set of 49 coding genes and 10 long noncoding RNAs (lncRNA), which are upregulated in NSCLC cell lines due to promoter hypomethylation, was uncovered. Twenty-two epigenetically regulated genes were validated (upregulated genes with hypomethylated promoters) in the adenocarcinoma and squamous cell cancer subtypes of lung cancer using The Cancer Genome Atlas data. Furthermore, it was demonstrated that multiple copies of the REP522 DNA repeat family are prominently upregulated due to hypomethylation in NSCLC cell lines, which leads to cancer-specific expression of lncRNAs, such as RP1-90G24.10, AL022344.4, and PCAT7. Finally, Myeloma Overexpressed (MYEOV) was identified as the most promising candidate. Functional studies demonstrated that MYEOV promotes cell proliferation, survival, and invasion. Moreover, high MYEOV expression levels were associated with poor prognosis. (C) 2017 AACR.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Kaczkowski, BogumilRIKEN Ctr Life Sci Technol, DGT, Yokohama, Kanagawa, Japan. (författare)
  • Ohshima, MitsuhiroOhu Univ, Dept Biochem, Sch Pharmaceut Sci, Koriyama, Fukushima, Japan. (författare)
  • Matsuzaki, HirotakaUniv Tokyo, Dept Resp Med, Grad Sch Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan. (författare)
  • Noguchi, SatoshiUniv Tokyo, Dept Resp Med, Grad Sch Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan. (författare)
  • Mikami, YuUniv Tokyo, Dept Resp Med, Grad Sch Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan.;Univ Tokyo, Grad Sch Med, Dept Clin Lab, Bunkyo Ku, Tokyo, Japan. (författare)
  • Lizio, MarinaRIKEN Ctr Life Sci Technol, DGT, Yokohama, Kanagawa, Japan. (författare)
  • Itoh, MasayoshiRIKEN Ctr Life Sci Technol, DGT, Yokohama, Kanagawa, Japan.;RIKEN Prevent Med & Diag Innovat Program, Wako, Saitama, Japan. (författare)
  • Kawaji, HideyaRIKEN Ctr Life Sci Technol, DGT, Yokohama, Kanagawa, Japan.;RIKEN Prevent Med & Diag Innovat Program, Wako, Saitama, Japan. (författare)
  • Lassmann, TimoRIKEN Ctr Life Sci Technol, DGT, Yokohama, Kanagawa, Japan.;Univ Western Australia, Telethon Kids Inst, Perth, WA, Australia. (författare)
  • Carninci, PieroRIKEN Ctr Life Sci Technol, DGT, Yokohama, Kanagawa, Japan. (författare)
  • Hayashizaki, YoshihideRIKEN Prevent Med & Diag Innovat Program, Wako, Saitama, Japan. (författare)
  • Forrest, Alistair R. R.RIKEN Ctr Life Sci Technol, DGT, Yokohama, Kanagawa, Japan.;Univ Western Australia, Harry Perkins Inst Med Res, QEII Med Ctr, Nedlands, WA, Australia.;Univ Western Australia, Ctr Med Res, Nedlands, WA, Australia. (författare)
  • Takai, DaiyaUniv Tokyo, Grad Sch Med, Dept Clin Lab, Bunkyo Ku, Tokyo, Japan. (författare)
  • Yamaguchi, YokoNihon Univ, Dept Biochem, Sch Dent, Chiyoda Ku, Tokyo, Japan.;Nihon Univ, Div Funct Morphol, Dent Res Ctr, Sch Dent,Chiyoda Ku, Tokyo, Japan. (författare)
  • Micke, PatrickUppsala universitet,Klinisk och experimentell patologi(Swepub:uu)patmi676 (författare)
  • Saito, AkiraUniv Tokyo, Dept Resp Med, Grad Sch Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan.;Univ Tokyo, Div Hlth Serv Promot, Bunkyo Ku, Tokyo, Japan. (författare)
  • Nagase, TakahideUniv Tokyo, Dept Resp Med, Grad Sch Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan. (författare)
  • Univ Tokyo, Dept Resp Med, Grad Sch Med, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1130033, Japan.;Univ Tokyo, Div Hlth Serv Promot, Bunkyo Ku, Tokyo, Japan.;RIKEN Ctr Life Sci Technol, DGT, Yokohama, Kanagawa, Japan.RIKEN Ctr Life Sci Technol, DGT, Yokohama, Kanagawa, Japan. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Molecular Cancer Research: AMER ASSOC CANCER RESEARCH15:10, s. 1354-13651541-77861557-3125

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