Sökning: WFRF:(Berthier Celine C.) >
Transcriptomic and ...
Transcriptomic and Proteomic Profiling Provides Insight into Mesangial Cell Function in IgA Nephropathy
-
- Liu, Peidi (författare)
- Univ Gothenburg, Inst Neurosci & Physiol, Dept Physiol, Gothenburg, Sweden.
-
- Lassen, Emelie (författare)
- Univ Gothenburg, Inst Neurosci & Physiol, Dept Physiol, Gothenburg, Sweden.
-
- Nair, Viji (författare)
- Univ Michigan, Dept Internal Med, Div Nephrol, Ann Arbor, MI 48109 USA.;Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA.
-
visa fler...
-
- Berthier, Celine C. (författare)
- Univ Michigan, Dept Internal Med, Div Nephrol, Ann Arbor, MI 48109 USA.;Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA.
-
- Suguro, Miyuki (författare)
- Aichi Canc Ctr Res Inst, Div Mol Med, Nagoya, Aichi, Japan.
-
- Sihlbom, Carina (författare)
- Univ Gothenburg, Prote Core Facil, Gothenburg, Sweden.
-
- Kretzler, Matthias (författare)
- Univ Michigan, Dept Internal Med, Div Nephrol, Ann Arbor, MI 48109 USA.;Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA.
-
- Betsholtz, Christer (författare)
- Karolinska Institutet,Uppsala universitet,Vaskulärbiologi,Karolinska Inst Novum, Integrated Cardio Metab Ctr, Huddinge, Sweden.
-
- Haraldsson, Borje (författare)
- Univ Gothenburg, Inst Neurosci & Physiol, Dept Physiol, Gothenburg, Sweden.
-
- Ju, Wenjun (författare)
- Univ Michigan, Dept Internal Med, Div Nephrol, Ann Arbor, MI 48109 USA.;Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA.
-
- Ebefors, Kerstin (författare)
- Univ Gothenburg, Inst Neurosci & Physiol, Dept Physiol, Gothenburg, Sweden.
-
- Nystrom, Jenny (författare)
- Univ Gothenburg, Inst Neurosci & Physiol, Dept Physiol, Gothenburg, Sweden.
-
visa färre...
-
Univ Gothenburg, Inst Neurosci & Physiol, Dept Physiol, Gothenburg, Sweden Univ Michigan, Dept Internal Med, Div Nephrol, Ann Arbor, MI 48109 USA.;Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA. (creator_code:org_t)
- AMER SOC NEPHROLOGY, 2017
- 2017
- Engelska.
-
Ingår i: Journal of the American Society of Nephrology. - : AMER SOC NEPHROLOGY. - 1046-6673 .- 1533-3450. ; 28:10, s. 2961-2972
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- IgA nephropathy (IgAN), the most common GN worldwide, is characterized by circulating galactose-deficient IgA (gd-IgA) that forms immune complexes. The immune complexes are deposited in the glomerular mesangium, leading to inflammation and loss of renal function, but the complete pathophysiology of the disease is not understood. Using an integrated global transcriptomic and proteomic profiling approach, we investigated the role of the mesangium in the onset and progression of IgAN. Global gene expression was investigated by microarray analysis of the glomerular compartment of renal biopsy specimens from patients with IgAN (n=19) and controls (n=22). Using curated glomerular cell type specific genes from the published literature, we found differential expression of a much higher percentage of mesangial cell positive standard genes than podocyte-positive standard genes in IgAN. Principal coordinate analysis of expression data revealed clear separation of patient and control samples on the basis of mesangial but not podocyte cell positive standard genes. Additionally, patient clinical parameters (serum creatinine values and eGFRs) significantly correlated with Z scores derived from the expression profile of mesangial cell positive standard genes. Among patients grouped according to Oxford MEST score, patients with segmental glomerulosclerosis had a significantly higher mesangial cell positive standard gene Z score than patients without segmental glomerulosclerosis. By investigating mesangial cell proteomics and glomerular transcriptomics, we identified 22 common pathways induced in mesangial cells by gd-IgA, most of which mediate inflammation. The genes, proteins, and corresponding pathways identified provide novel insights into the pathophysiologic mechanisms leading to IgAN.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Liu, Peidi
-
Lassen, Emelie
-
Nair, Viji
-
Berthier, Celine ...
-
Suguro, Miyuki
-
Sihlbom, Carina
-
visa fler...
-
Kretzler, Matthi ...
-
Betsholtz, Chris ...
-
Haraldsson, Borj ...
-
Ju, Wenjun
-
Ebefors, Kerstin
-
Nystrom, Jenny
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Urologi och njur ...
- Artiklar i publikationen
-
Journal of the A ...
- Av lärosätet
-
Uppsala universitet
-
Karolinska Institutet