In situ hybridization studies favouring the occurrence of a local production of BDNF in the human Achilles tendon

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Bagge, JohanUmeå universitet,Anatomi (author)

In situ hybridization studies favouring the occurrence of a local production of BDNF in the human Achilles tendon

Article/chapterEnglish2012

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2012
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LIBRIS-ID:oai:DiVA.org:umu-57811
https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-57811URI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:art swepub-publicationtype

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Brain derived neurotrophic factor (BDNF) is a multipotent neurotrophin known for its growth-influencing and apoptosis-modulating functions, as well as for its function to interact with neurotransmitters/neuromodulators. BDNF is reported to be mainly produced in the brain. BDNF can be absorbed into peripheral tissue from the blood stream. Expression of this neurotrophin at the protein level, as well as of the neurotrophin receptor p75, has been previously shown for the principal cells (tenocytes) of the Achilles tendon. However, there is no proof at the mRNA level that BDNF is produced by the tenocytes. As the Achilles tendon tenocytes show "neuronal-like" characteristics, in the form of expressions favouring synthesis of several neuromodulators/neurotransmitters, and as BDNF especially is produced in neurons, it is of interest to confirm this. In the present study, therefore, in situ hybridization for demonstration of BDNF mRNA was performed on biopsies from Achilles tendons of patients with tendinosis and pain-free non-tendinosis individuals. The results showed that the tenocytes of both groups exhibited BDNF mRNA reactions. These observations indeed favour the idea that BDNF is produced by tenocytes in the human Achilles tendon, why Achilles tendon tissue is a tissue in which BDNF can be locally produced. BDNF can have modulatory functions for the tenocytes, including apoptosis-modifying effects via actions on the p75 receptor and interactive effects with neurotransmitters/neuromodulators produced in these cells. This possibility should be further studied for Achilles tendon tissue.

Subject headings and genre

NATURVETENSKAP Biologi Cellbiologi hsv//swe
NATURAL SCIENCES Biological Sciences Cell Biology hsv//eng
Achilles tendon
BDNF
mRNA
In situ hybridization
Tendinopathy

Added entries (persons, corporate bodies, meetings, titles ...)

Danielson, PatrikUmeå universitet,Anatomi(Swepub:umu)pakdan00 (author)
Forsgren, StureUmeå universitet,Anatomi(Swepub:umu)stfo0001 (author)
Umeå universitetAnatomi (creator_code:org_t)

Related titles

In:Histology and Histopathology27:9, s. 1239-12460213-39111699-5848

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NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Cell Biology

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By the university: Umeå University

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