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The prevalence of T...
The prevalence of Type 2 diabetes is not increased in normal-weight women with PCOS
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- Pelanis, Rasa (författare)
- Oslo Univ Hosp, Div Obstet & Gynecol, Dept Reprod Med, Oslo, Norway.
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- Mellembakken, Jan Roar (författare)
- Oslo Univ Hosp, Div Obstet & Gynecol, Dept Reprod Med, Oslo, Norway.
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- Sundström Poromaa, Inger, 1964- (författare)
- Uppsala universitet,Reproduktiv hälsa
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- Ravn, Pernille (författare)
- Odense Univ Hosp, Dept Gynaecol & Obstet, Odense, Denmark.
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- Morin-Papunen, Laure (författare)
- Univ Oulu, Oulu Univ Hosp, Dept Obstet & Gynaecol, Oulu, Finland.;Med Res Ctr, Oulu, Finland.;PEDEGO Res Unit Paediat Dermatol Clin Genet Obste, Oulu, Finland.
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- Tapanainen, Juha S. (författare)
- Univ Oulu, Oulu Univ Hosp, Dept Obstet & Gynaecol, Oulu, Finland.;Med Res Ctr, Oulu, Finland.;PEDEGO Res Unit Paediat Dermatol Clin Genet Obste, Oulu, Finland.;Helsinki Univ Hosp, Dept Obstet & Gynaecol, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.
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- Piltonen, Terhi (författare)
- Univ Oulu, Oulu Univ Hosp, Dept Obstet & Gynaecol, Oulu, Finland.;Med Res Ctr, Oulu, Finland.;PEDEGO Res Unit Paediat Dermatol Clin Genet Obste, Oulu, Finland.
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- Puurunen, Johanna (författare)
- Univ Oulu, Oulu Univ Hosp, Dept Obstet & Gynaecol, Oulu, Finland.;Med Res Ctr, Oulu, Finland.;PEDEGO Res Unit Paediat Dermatol Clin Genet Obste, Oulu, Finland.
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- Hirschberg, Angelica Linden (författare)
- Karolinska Institutet
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- Fedorcsak, Peter (författare)
- Univ Oslo, Fac Med, Oslo, Norway.
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- Andersen, Marianne (författare)
- Odense Univ Hosp, Dept Endocrinol, Klovervaenget 6,6th Floor, DK-5000 Odense C, Denmark.
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- Glintborg, Dorte (författare)
- Odense Univ Hosp, Dept Endocrinol, Klovervaenget 6,6th Floor, DK-5000 Odense C, Denmark.
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Oslo Univ Hosp, Div Obstet & Gynecol, Dept Reprod Med, Oslo, Norway Reproduktiv hälsa (creator_code:org_t)
- 2017-09-29
- 2017
- Engelska.
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Ingår i: Human Reproduction. - : OXFORD UNIV PRESS. - 0268-1161 .- 1460-2350. ; 32:11, s. 2279-2286
- Relaterad länk:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- STUDY QUESTION: Is oral glucose tolerance test (OGTT) needed in all women with polycystic ovary syndrome (PCOS)? SUMMARY QNSWER: OGTT is not routinely needed in women with PCOS and BMI < 25 kg/m(2). WHAT IS KNOWN ALREADY: PCOS is associated with insulin resistance and increased prevalence of prediabetes and Type 2 diabetes (T2D) which is closely linked to obesity and possibly age, ethnicity and PCOS phenotype. Several guidelines recommend OGTT upon diagnosis of PCOS and during follow-up. STUDY DESIGN, SIZE, DURATION: A Nordic cross-sectional study including 876 women. PARTICIPANTS/MATERIALS, SETTING, METHODS: The 876 Nordic women with PCOS, aged 14-57 years, were examined for T2D and prediabetes (impaired glucose tolerance [IGT] or impaired fasting glucose (IFG) by OGTT. MAIN RESULT AND THE ROLE OF CHANCE: Of all study subjects 3% (23/876) had T2D, 23% (204/876) prediabetes and 74% (649/876) had normal glucose tolerance (NGT). Increased BMI and waist circumference were significantly (P < 0.001) associated with prevalence of prediabetes and T2D. No normal-weight woman (BMI < 25 kg/m(2)) was diagnosed with (TD)-D-2. The prevalence of BMI >= 25 kg/m(2) was 66% (578/876). 91% of women (21/23) with T2D had BMI >= 30 kg/m(2). Testosterone levels and PCOS phenotype did not predict 2-h glucose levels during OGTT after adjustment for BMI and age. LIMITATIONS, REASONS FOR CAUTION: The present study included cross-sectional data and prospective studies are needed to confirm our results. These results may not apply to populations of other ethnic origin. WIDER IMPLICATIONS OF THE FINDINGS: Routine OGTT may not be indicated in normal-weight women with PCOS.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- Polycystic ovary syndrome
- Type 2 diabetes
- lean
- BMI
- oral glucose tolerance test
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- ref (ämneskategori)
- art (ämneskategori)
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Pelanis, Rasa
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Mellembakken, Ja ...
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Sundström Poroma ...
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Ravn, Pernille
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Morin-Papunen, L ...
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Tapanainen, Juha ...
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Piltonen, Terhi
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Puurunen, Johann ...
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Hirschberg, Ange ...
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Fedorcsak, Peter
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Andersen, Marian ...
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Glintborg, Dorte
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