Search: WFRF:(Oberthuer Dominik) >
Mix-and-diffuse ser...
Mix-and-diffuse serial synchrotron crystallography
-
- Beyerlein, Kenneth R. (author)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Elect Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.
-
- Dierksmeyer, Dennis (author)
- Deutsch Elektronen Synchrotron DESY, Photon Sci, Hamburg, Germany.
-
- Mariani, Valerio (author)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Elect Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.
-
show more...
-
- Kuhn, Manuela (author)
- Deutsch Elektronen Synchrotron DESY, Photon Sci, Hamburg, Germany.
-
- Sarrou, Iosifina (author)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Elect Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.
-
- Ottaviano, Angelica (author)
- Calif State Univ Northridge, Dept Phys, Northridge, CA 91330 USA.
-
- Awel, Salah (author)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Elect Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.;Univ Hamburg, Hamburg Ctr Ultrafast Imaging, D-22761 Hamburg, Germany.
-
- Knoska, Juraj (author)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Elect Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.;Univ Hamburg, Dept Phys, Luruper Chaussee 149, D-22607 Hamburg, Germany.
-
- Fuglerud, Silje (author)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Elect Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.;Norwegian Univ Sci & Technol, Dept Phys, Trondheim, Norway.
-
- Jönsson, Olof (author)
- Uppsala universitet,Molekyl- och kondenserade materiens fysik
-
- Stern, Stephan (author)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Elect Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.;European Xray Free Elect Laser Facil GmbH XFEL, Schenefeld, Germany.
-
- Wiedorn, Max O. (author)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Elect Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.;Univ Hamburg, Dept Phys, Luruper Chaussee 149, D-22607 Hamburg, Germany.
-
- Yefanov, Oleksandr (author)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Elect Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.
-
- Adriano, Luigi (author)
- Deutsch Elektronen Synchrotron DESY, Photon Sci, Hamburg, Germany.
-
- Bean, Richard (author)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Elect Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.
-
- Burkhardt, Anja (author)
- Deutsch Elektronen Synchrotron DESY, Photon Sci, Hamburg, Germany.
-
- Fischer, Pontus (author)
- Deutsch Elektronen Synchrotron DESY, Photon Sci, Hamburg, Germany.
-
- Heymann, Michael (author)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Elect Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.
-
- Horke, Daniel A. (author)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Elect Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.;Univ Hamburg, Hamburg Ctr Ultrafast Imaging, D-22761 Hamburg, Germany.
-
- Jungnickel, Katharina E. J. (author)
- Univ Oxford, Dept Biochem, Oxford, England.
-
- Kovaleva, Elena (author)
- SLAC Natl Accelerator Lab, SSRL, Menlo Pk, CA USA.
-
- Lorbeer, Olga (author)
- Deutsch Elektronen Synchrotron DESY, Photon Sci, Hamburg, Germany.
-
- Metz, Markus (author)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Elect Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.
-
- Meyer, Jan (author)
- Deutsch Elektronen Synchrotron DESY, Photon Sci, Hamburg, Germany.
-
- Morgan, Andrew (author)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Elect Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.
-
- Pande, Kanupriya (author)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Elect Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.
-
- Panneerselvam, Saravanan (author)
- Deutsch Elektronen Synchrotron DESY, Photon Sci, Hamburg, Germany.
-
- Seuring, Carolin (author)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Elect Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.;Univ Hamburg, Hamburg Ctr Ultrafast Imaging, D-22761 Hamburg, Germany.
-
- Tolstikova, Aleksandra (author)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Elect Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.
-
- Lieske, Julia (author)
- Deutsch Elektronen Synchrotron DESY, Photon Sci, Hamburg, Germany.
-
- Aplin, Steve (author)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Elect Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.
-
- Roessle, Manfred (author)
- Fachhsch Lubeck, Lubeck, Germany.
-
- White, Thomas A. (author)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Elect Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.
-
- Chapman, Henry N. (author)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Elect Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.;Univ Hamburg, Hamburg Ctr Ultrafast Imaging, D-22761 Hamburg, Germany.;Univ Hamburg, Dept Phys, Luruper Chaussee 149, D-22607 Hamburg, Germany.
-
- Meents, Alke (author)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Elect Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.;Deutsch Elektronen Synchrotron DESY, Photon Sci, Hamburg, Germany.
-
- Oberthuer, Dominik (author)
- Deutsch Elektronen Synchrotron DESY, Ctr Free Elect Laser Sci, Notkestr 85, D-22607 Hamburg, Germany.
-
show less...
-
Deutsch Elektronen Synchrotron DESY, Ctr Free Elect Laser Sci, Notkestr 85, D-22607 Hamburg, Germany Deutsch Elektronen Synchrotron DESY, Photon Sci, Hamburg, Germany. (creator_code:org_t)
- INT UNION CRYSTALLOGRAPHY, 2017
- 2017
- English.
-
In: IUCrJ. - : INT UNION CRYSTALLOGRAPHY. - 2052-2525. ; 4:6, s. 769-777
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Unravelling the interaction of biological macromolecules with ligands and substrates at high spatial and temporal resolution remains a major challenge in structural biology. The development of serial crystallography methods at X-ray free-electron lasers and subsequently at synchrotron light sources allows new approaches to tackle this challenge. Here, a new polyimide tape drive designed for mix-and-diffuse serial crystallography experiments is reported. The structure of lysozyme bound by the competitive inhibitor chitotriose was determined using this device in combination with microfluidic mixers. The electron densities obtained from mixing times of 2 and 50 s show clear binding of chitotriose to the enzyme at a high level of detail. The success of this approach shows the potential for high-throughput drug screening and even structural enzymology on short timescales at bright synchrotron light sources.
Subject headings
- NATURVETENSKAP -- Kemi -- Materialkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Materials Chemistry (hsv//eng)
Keyword
- drug discovery
- protein structure
- X-ray crystallography
- serial crystallography
- time-resolved studies
- lysozyme
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
IUCrJ
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Beyerlein, Kenne ...
-
Dierksmeyer, Den ...
-
Mariani, Valerio
-
Kuhn, Manuela
-
Sarrou, Iosifina
-
Ottaviano, Angel ...
-
show more...
-
Awel, Salah
-
Knoska, Juraj
-
Fuglerud, Silje
-
Jönsson, Olof
-
Stern, Stephan
-
Wiedorn, Max O.
-
Yefanov, Oleksan ...
-
Adriano, Luigi
-
Bean, Richard
-
Burkhardt, Anja
-
Fischer, Pontus
-
Heymann, Michael
-
Horke, Daniel A.
-
Jungnickel, Kath ...
-
Kovaleva, Elena
-
Lorbeer, Olga
-
Metz, Markus
-
Meyer, Jan
-
Morgan, Andrew
-
Pande, Kanupriya
-
Panneerselvam, S ...
-
Seuring, Carolin
-
Tolstikova, Alek ...
-
Lieske, Julia
-
Aplin, Steve
-
Roessle, Manfred
-
White, Thomas A.
-
Chapman, Henry N ...
-
Meents, Alke
-
Oberthuer, Domin ...
-
show less...
- About the subject
-
- NATURAL SCIENCES
-
NATURAL SCIENCES
-
and Chemical Science ...
-
and Materials Chemis ...
- Articles in the publication
-
IUCrJ
- By the university
-
Uppsala University