Search: id:"swepub:oai:DiVA.org:uu-341324" >
Comorbidities in re...
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Quintana, Hedley KnewjenKarolinska Inst, Inst Environm Med, Unit Cardiovasc Epidemiol, Stockholm, Sweden.
(author)
Comorbidities in relation to fatali of first myocardial infarction
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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ELSEVIER SCIENCE INC,2018
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LIBRIS-ID:oai:DiVA.org:uu-341324
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-341324URI
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https://doi.org/10.1016/j.carpath.2017.11.002DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:137344620URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Introduction: Present knowledge concerning potential associations between comorbidities and the fatality of a first myocardial infarction (MI) is limited.Aim: To identify comorbidities in 45-70-year-old individuals who suffered a first MI and died within 7 days in Stockholm County from 1992-1994. In addition, to assess how each of the comorbidities identified, as well as the number of hospitalizations during the 10-year period prior to the MI, was associated with MI fatality.Methods: The data collected on our inception cohort of 1984 first Ml, of which 524 were fatal within 7 days, were primarily self-reported, proxy-reported by questionnaire and/or extracted from comprehensive national registers. Comorbidilies among fatal cases with a prevalence >2% were identified. Risk ratios (with 95% confidence intervals) for the association of Ml fatality with number of prior hospitalizations and specific comorbidities were calculated using binomial regression with log link. A structured review of autopsy reports on fatal cases was performed in order to identify additional indicators of comorbidities.Results: After adjusting for sex, age and disposable income, the number of previous hospitalizations was associated with 7-day Ml fatality. Of the comorbidities identified as prevalent in fatal cases, the following were associated with 7-day fatality in crude analysis: epilepsy, heart failure, stroke, alcoholism, cancer, renal diseases, asthma, psychiatric diseases, diabetes, and rheumatoid arthritis. Indicators of comorbidities identified from autopsy data included a silent MI, severe atherosclerosis of the abdominal aorta, and hepatic steatosis. Adjustments for sex and age (although not possible for epilepsy and alcoholism), did not substantially alter results.Conclusions: Our current findings indicate that in connection with a first MI, particular attention should be paid to those with repeated prior hospitalizations and/or epilepsy, heart failure, stroke, alcoholism, cancer, renal diseases, asthma, psychiatric diseases, diabetes and rheumatoid arthritis.
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Janszky, ImreKarolinska Institutet
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Kanar, AlkassKarolinska Inst, Dept Oncol Pathol, Stockholm, Sweden.
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Gigante, BrunaKarolinska Institutet
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Druid, HenriKarolinska Institutet
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Ahlbom, AndersKarolinska Institutet
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de Faire, UlfKarolinska Institutet
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Hallqvist, Johan,1950-Uppsala universitet,Allmänmedicin och preventivmedicin(Swepub:uu)johha694
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Leander, KarinKarolinska Institutet
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Karolinska InstitutetKarolinska Inst, Inst Environm Med, Unit Cardiovasc Epidemiol, Stockholm, Sweden.
(creator_code:org_t)
Related titles
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In:Cardiovascular pathology: ELSEVIER SCIENCE INC32, s. 32-371054-88071879-1336
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