Search: WFRF:(Gabriel Guelsah) >
Antiviral Propertie...
Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins
-
- Bulanova, Daria (author)
- Univ Helsinki, FIMM, Inst Mol Med Finland, FIN-00290 Helsinki, Finland.
-
- Ianevski, Aleksandr (author)
- Univ Helsinki, FIMM, Inst Mol Med Finland, FIN-00290 Helsinki, Finland.
-
- Bugai, Andrii (author)
- Univ Helsinki, Dept Biochem & Dev Biol, FIN-00290 Helsinki, Finland.
-
show more...
-
- Akimov, Yevhen (author)
- Univ Helsinki, FIMM, Inst Mol Med Finland, FIN-00290 Helsinki, Finland.
-
- Kuivanen, Suvi (author)
- Univ Helsinki, Dept Virol, Haartmaninkatu 3, FIN-00290 Helsinki, Finland.
-
- Paavilainen, Henrik (author)
- Univ Turku, Dept Virol, FIN-20520 Turku, Finland.
-
- Kakkola, Laura (author)
- Univ Turku, Dept Virol, FIN-20520 Turku, Finland.
-
- Nandania, Jatin (author)
- Univ Helsinki, FIMM, Inst Mol Med Finland, FIN-00290 Helsinki, Finland.
-
- Turunen, Laura (author)
- Univ Helsinki, FIMM, Inst Mol Med Finland, FIN-00290 Helsinki, Finland.
-
- Ohman, Tiina (author)
- Univ Helsinki, Inst Biotechnol, Valimotie 7, Helsinki 00014, Finland.
-
- Ala-Hongisto, Hanna (author)
- Biomed Funct Genom Unit FuGU, Helsinki 00290, Helsinki, Finland.
-
- Pesonen, Hanna M. (author)
- Biomed Funct Genom Unit FuGU, Helsinki 00290, Helsinki, Finland.
-
- Kuisma, Marika S. (author)
- Biomed Funct Genom Unit FuGU, Helsinki 00290, Helsinki, Finland.
-
- Honkimaa, Anni (author)
- Univ Tampere, Dept Virol, Tampere 33520, Finland.
-
- Walton, Emma L. (author)
- Norwegian Univ Sci & Technol, Dept Clin & Mol Med, N-7028 Trondheim, Norway.
-
- Oksenych, Valentyn (author)
- Norwegian Univ Sci & Technol, Dept Clin & Mol Med, N-7028 Trondheim, Norway.
-
- Lorey, Martina B. (author)
- Univ Helsinki, FIN-00290 Helsinki, Finland.;Helsinki Univ Hosp, Rheumatol, Helsinki 00290, Finland.
-
- Guschin, Dmitry (author)
- Inst Pasteur Korea, Gyeonggi Do 13488, South Korea.
-
- Shim, Jungmin (author)
- Inst Pasteur Korea, Gyeonggi Do 13488, South Korea.
-
- Kim, Jinhee (author)
- Inst Pasteur Korea, Gyeonggi Do 13488, South Korea.
-
- Than, Thoa T. (author)
- Inst Pasteur Korea, Gyeonggi Do 13488, South Korea.
-
- Chang, So Young (author)
- Inst Pasteur Korea, Gyeonggi Do 13488, South Korea.
-
- Hukkanen, Veijo (author)
- Univ Turku, Dept Virol, FIN-20520 Turku, Finland.
-
- Kulesskiy, Evgeny (author)
- Univ Helsinki, FIMM, Inst Mol Med Finland, FIN-00290 Helsinki, Finland.
-
- Marjomaki, Varpu S. (author)
- Univ Jyvaskyla, Dept Biol & Environm Sci, Nanosci Ctr, Jyvaskyla 40500, Finland.
-
- Julkunen, Ilkka (author)
- Univ Turku, Dept Virol, FIN-20520 Turku, Finland.
-
- Nyman, Tuula A. (author)
- Univ Helsinki, Inst Biotechnol, Valimotie 7, Helsinki 00014, Finland.;Univ Oslo, Dept Immunol, N-0424 Oslo, Norway.
-
- Matikainen, Sampsa (author)
- Univ Helsinki, FIN-00290 Helsinki, Finland.;Helsinki Univ Hosp, Rheumatol, Helsinki 00290, Finland.
-
- Saarela, Jani S. (author)
- Univ Helsinki, FIMM, Inst Mol Med Finland, FIN-00290 Helsinki, Finland.
-
- Sane, Famara (author)
- Univ Lille, CHU Lille, Lab Virol, EA3610, F-59037 Lille, France.
-
- Hober, Didier (author)
- Univ Lille, CHU Lille, Lab Virol, EA3610, F-59037 Lille, France.
-
- Gabriel, Guelsah (author)
- Leibniz Inst Expt Virol, Heinrich Pette Inst, D-20251 Hamburg, Germany.
-
- De Brabander, Jef K. (author)
- Univ Texas Southwestern Med Ctr Dallas, Dept Biochem, Dallas, TX 75390 USA.
-
- Martikainen, Miika (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk immunologi
-
- Windisch, Marc P. (author)
- Inst Pasteur Korea, Gyeonggi Do 13488, South Korea.
-
- Min, Ji-Young (author)
- Inst Pasteur Korea, Gyeonggi Do 13488, South Korea.
-
- Bruzzone, Roberto (author)
- Inst Pasteur Korea, Gyeonggi Do 13488, South Korea.;Univ Hong Kong, Sch Publ Hlth, HKU Pasteur Res Pole, Hong Kong, Hong Kong, Peoples R China.;Inst Pasteur, Dept Cell Biol & Infect, F-75015 Paris, France.
-
- Aittokallio, Tero (author)
- Univ Helsinki, FIMM, Inst Mol Med Finland, FIN-00290 Helsinki, Finland.
-
- Vaha-Koskela, Markus (author)
- Univ Helsinki, FIMM, Inst Mol Med Finland, FIN-00290 Helsinki, Finland.
-
- Vapalahti, Olli (author)
- Univ Helsinki, Dept Virol & Immunol, FIN-00014 Helsinki, Finland.;Helsinki Univ Hosp, Helsinki 00014, Finland.;Univ Helsinki, Dept Vet Biosci, FIN-00014 Helsinki, Finland.
-
- Pulk, Arto (author)
- Univ Tartu, Inst Technol, EE-50090 Tartu, Estonia.
-
- Velagapudi, Vidya (author)
- Univ Helsinki, FIMM, Inst Mol Med Finland, FIN-00290 Helsinki, Finland.
-
- Kainov, Denis E. (author)
- Univ Helsinki, FIMM, Inst Mol Med Finland, FIN-00290 Helsinki, Finland.;Norwegian Univ Sci & Technol, Dept Clin & Mol Med, N-7028 Trondheim, Norway.;Inst Pasteur Korea, Gyeonggi Do 13488, South Korea.;Univ Tartu, Inst Technol, EE-50090 Tartu, Estonia.
-
show less...
-
Univ Helsinki, FIMM, Inst Mol Med Finland, FIN-00290 Helsinki, Finland Univ Helsinki, Dept Biochem & Dev Biol, FIN-00290 Helsinki, Finland. (creator_code:org_t)
- 2017-09-25
- 2017
- English.
-
In: Viruses. - : MDPI AG. - 1999-4915. ; 9:10
- Related links:
-
https://doi.org/10.3...
-
show more...
-
https://uu.diva-port... (primary) (Raw object)
-
https://www.mdpi.com...
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
show less...
Abstract
Subject headings
Close
- Viral diseases remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral diseases, new treatments are urgently needed. Here we show that small-molecules, which inhibit cellular anti-apoptotic Bcl-2 proteins (Bcl-2i), induced the premature death of cells infected with different RNA or DNA viruses, whereas, at the same concentrations, no toxicity was observed in mock-infected cells. Moreover, these compounds limited viral replication and spread. Surprisingly, Bcl-2i also induced the premature apoptosis of cells transfected with viral RNA or plasmid DNA but not of mock-transfected cells. These results suggest that Bcl-2i sensitizes cells containing foreign RNA or DNA to apoptosis. A comparison of the toxicity, antiviral activity, and side effects of six Bcl-2i allowed us to select A-1155463 as an antiviral lead candidate. Thus, our results pave the way for the further development of Bcl-2i for the prevention and treatment of viral diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- apoptosis
- antiviral agent
- innate immunity
- host response
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Viruses
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
Bulanova, Daria
-
Ianevski, Aleksa ...
-
Bugai, Andrii
-
Akimov, Yevhen
-
Kuivanen, Suvi
-
Paavilainen, Hen ...
-
show more...
-
Kakkola, Laura
-
Nandania, Jatin
-
Turunen, Laura
-
Ohman, Tiina
-
Ala-Hongisto, Ha ...
-
Pesonen, Hanna M ...
-
Kuisma, Marika S ...
-
Honkimaa, Anni
-
Walton, Emma L.
-
Oksenych, Valent ...
-
Lorey, Martina B ...
-
Guschin, Dmitry
-
Shim, Jungmin
-
Kim, Jinhee
-
Than, Thoa T.
-
Chang, So Young
-
Hukkanen, Veijo
-
Kulesskiy, Evgen ...
-
Marjomaki, Varpu ...
-
Julkunen, Ilkka
-
Nyman, Tuula A.
-
Matikainen, Samp ...
-
Saarela, Jani S.
-
Sane, Famara
-
Hober, Didier
-
Gabriel, Guelsah
-
De Brabander, Je ...
-
Martikainen, Mii ...
-
Windisch, Marc P ...
-
Min, Ji-Young
-
Bruzzone, Robert ...
-
Aittokallio, Ter ...
-
Vaha-Koskela, Ma ...
-
Vapalahti, Olli
-
Pulk, Arto
-
Velagapudi, Vidy ...
-
Kainov, Denis E.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Microbiology in ...
- Articles in the publication
-
Viruses
- By the university
-
Uppsala University